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This section provides an overview for sodium amide as well as their applications and principles. Also, please take a look at the list of 17 sodium amide manufacturers and their company rankings. Here are the top-ranked sodium amide companies as of December, 2024: 1.KANTO CHEMICAL CO.,INC., 2.LobaChemie Pct.Ltd., 3.Hefei Home Sunshine Pharmaceutical Technology Co., Ltd..
Table of Contents
Sodium amide is an inorganic compound consisting of a polymeric series of N-Na bonds.
It has an ammonia-like odor and a melting point of 210°C. It decomposes at about 500°C. Its chemical formula is NaNH2. Its chemical formula is NaNH2, and it is mainly used as a strong base in chemical synthesis. Its molecular mass is 30.01 and its CAS number is 7782-92-5. It is also known as "sodamide. At room temperature, it exists in solid form, colorless in its pure form and gray in its less pure form.
Sodium amide sold commercially appears gray because it contains iron as an impurity, but this does not affect its quality. It is tidily soluble and is hydrolyzed by oxygen in the air to sodium nitrite. Care must be taken when storing it, as it may be altered by light.
Sodium amide is used as a strong base in chemical synthesis because of its low nucleophilicity, and it can be used in situations where nucleophilic attack is to be avoided. However, due to its low solubility in ordinary organic solvents, it is mainly used in reactions in which liquid ammonia is used as a solvent.
Specifically, it is used in the reaction to form carbon-carbon bonds by de-protonating acetylene and using acetylene as a nucleophile. This reaction can be used to synthesize alkanes and alkenes by reducing the synthesized acetylene, and can also be used to synthesize carbonyl compounds by hydrolysis.
The benzaine reaction also uses the basicity of sodium amide to exchange substituents on the benzene ring by withdrawing hydrogen from the benzene ring to form benzaine. Other reactions include the synthesis of alkyl ketones and the titibabine reaction, which introduces an amino group on the carbon adjacent to the nitrogen atom of the pyridine ring.
Reactions carried out in organic solvents, such as lithium diisopropylamide (LDA), are often used. Apart from its use as a base, it is also used as a condensing agent and as a reducing agent for organic molecules.
Other uses include its use as a raw material for indigo, hydrazine, and sodium cyanide. Indigo is a dye and has been used to dye denim and jeans. Sodium amide by itself is also used as a desiccant and dehydrating agent to remove trace amounts of water in ammonia; in 2018, a reaction was reported in which mixing chloride and sodium amide can synthesize oxynitrides by an instantaneous temperature rise reaction.
The crystal structure of sodium amide is orthorhombic, with an alternating polymeric succession of nitrogen and sodium atoms.
It has a structure in which four nitrogen atoms are coordinated to one sodium atom,and is conductive when dissolved in liquid ammonia. Sodium amide dissolved in liquid ammonia is called ammono base. Ammono bases are characterized by their ability to dissolve metals such as magnesium, zinc, and molybdenum, as well as glass.
Sodium amide can be synthesized from metallic sodium and gaseous ammonia, but is usually synthesized from liquid ammonia using iron (III) nitrate as a catalyst. 38 It is a strong base because it has a high acid dissociation constant (pKa).
Although not regulated by major national laws and regulations, sodium amide is a strong base compound that is highly irritating and can cause irritation to the skin. When handling, be sure to wear a lab coat, protective glasses, and gloves.
In addition, it should be stored in a dry environment because it reacts violently when exposed to water, producing sodium hydroxide and ammonia, a toxic gas. Particular attention should be paid to accidents that have occurred in the past where fire has been caused by contact with moisture; it is best to store at temperatures above 30°C (86°F).
*Including some distributors, etc.
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American Elements was founded in 1997 in California and currently has research and production facilities in Utah, Mexico, China, and the United Kingdom. AE manufactures and distributes advanced materials from a catalog of over 30,000 products for bulk industrial use as well as small scale laboratory use. AE also provides testing and analyses services including spectroscopy along with structural, thermal, and electrical analyses. AE holds sustainable development as a core corporate value and is committed to work to protect the health of the environment.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Alkali Metals Ltd, founded in 1968 and headquartered in Telangana, India, is a manufacturer and supplier of specialty chemicals. Their product portfolio encompasses alkali metal derivatives, pyridine derivatives, tetrazoles, cyclic compounds, and fine chemicals which find applications in pharmaceuticals, agrochemicals, plastics, and dyes production. Additionally, their fine chemicals cater to various sectors, including pharmaceuticals, agrochemicals, and electronics. The company is an ISO 9001 and 14001 certified company following GMP Standards.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Hefei Home Sunshine Pharmaceutical Technology Co., Ltd, established in 2013 and headquartered in Hefei City, China, is a manufacturer specializing in both standard and custom chemical synthesis. With manufacturing facilities in Anhui, Jiangsu, Zhejiang, and Inner Mongolia, Home Sunshine Pharma offers a range of products, including active pharmaceutical ingredients (APIs), intermediates, fine chemicals, coenzymes, and nucleotides. As an ISO 9001:2015 certified company, Home Sunshine Pharma serves research institutions, universities, and industries in Europe, America, and Southeast Asia with their chemical products.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Henan Bon Industrial Company Ltd which was started in 2009, is a distributor, and manufacturer of agrochemicals, catalysts and chemical auxiliary agents. The company is located in Zhengzhou High-tech Development Zone. In 2011, it expanded its product line and entered the Fine Chemical market. Under this wing, they supply noble metal catalysts. They also produce organic phosphine ligands and OLED intermediates. Additionally, they synthesize electronic chemical materials and general chemicals. The main clientele is within the production and life science fields.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
India Fine Chemicals, founded in 1978 and headquartered in Taito-ku, Tokyo, Japan, is a distributor and supplier of chemicals, functional materials, food additives, as well as a planner and developer of health foods. The company offers an extensive range of products, including sodium vinylsulfonate 25% water solution, sodium cumene sulfonate, N-dimethyl-1,3-propanediamine, and diethyl sulfate. These chemicals serve various industries, including pharmaceuticals, agrochemicals, cosmetics, dyes, and flavors. The company also offers a range of services, including information about chemicals, a chemical search engine, product analysis, and contract development.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | KANTO CHEMICAL CO.,INC. |
33.3%
|
| 2 | LobaChemie Pct.Ltd. |
16.7%
|
| 3 | Hefei Home Sunshine Pharmaceutical Technology Co., Ltd. |
16.7%
|
| 4 | Kishida Chemical Co.,Ltd. |
16.7%
|
| 5 | FUJIFILM Wako Pure Chemical Corporation |
16.7%
|
Derivation Method
The ranking is calculated based on the click share within the sodium amide page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
4 | 28.6% |
|
United States of America
|
3 | 21.4% |
|
Japan
|
3 | 21.4% |
|
China
|
3 | 21.4% |
|
United Kingdom
|
1 | 7.1% |
