9 Toluidine Manufacturers in 2024
This section provides an overview for toluidine as well as their applications and principles. Also, please take a look at the list of 9 toluidine manufacturers and their company rankings. Here are the top-ranked toluidine companies as of November, 2024: 1.Aarti Industries Limited.
Table of Contents
What Is Toluidine?
Toluidine is an aromatic compound featuring an amino group and a methyl group attached to the benzene ring.
It belongs to the class of aniline derivatives and aromatic amines, with three isomers: o-toluidine, m-toluidine, and p-toluidine, differing in the positional relationship between the amino and methyl groups. Among these, o-toluidine and m-toluidine are liquids, while p-toluidine is a solid at room temperature and pressure.
Uses of Toluidine
Toluidine serves primarily as an intermediate in chemical synthesis and finds applications across various industrial sectors.
For instance, o-toluidine is employed as a raw material for toluidine blue dye production. Toluidine blue, derived from o-toluidine, thiazine, and phenothiazine, is a blue basic dye that stains negatively charged materials and is particularly useful for biomaterial and plant staining.
Furthermore, toluidine serves as a precursor in pharmaceutical synthesis and rubber vulcanization.
Properties of Toluidine
Toluidine, an aniline derivative, and aromatic amine, exists in three isomers: o-toluidine, m-toluidine, and p-toluidine. Its chemical formula is C7H9N, with a molecular weight of 107.15 g/mol. While slightly soluble in water, it readily dissolves in organic solvents such as ethanol, ether, and acetone. Pure toluidine appears as a colorless or slightly yellow crystal or liquid but may turn brown upon oxidation in the air.
Each isomer exhibits distinct melting and boiling points:
- o-Toluidine: Melting point -23°C, Boiling point 200°C
- m-Toluidine: Melting point -30°C, Boiling point 203°C
- p-Toluidine: Melting point 43°C, Boiling point 200°C
Notably, o-toluidine is considered carcinogenic and mutagenic, warranting careful handling.
Structure of Toluidine
Toluidine, a derivative of aniline (C6H5NH2), represents an aromatic amine with the chemical formula C6H4(CH3)NH2.
Existing as three isomers, o-toluidine, m-toluidine, and p-toluidine, these compounds feature methyl groups attached at different positions on the benzene ring. Consequently, they exhibit distinct physical and chemical properties based on the relative positions of the methyl and amino groups.
All toluidine isomers share the characteristics of aromatic amines and can react with acids to form salts and with oxidizing and reducing agents.
Other Information on Toluidine
1. Toluidine Production Methods
Toluidine is primarily produced through the following methods:
- Reduction of Nitrotoluene: Toluidine is commonly synthesized via the reduction of nitrotoluene, achieved through chemical reduction using iron or zinc powder and acid or by catalytic hydrogenation reduction.
- Synthesis from Aniline: An alternative route involves synthesizing toluidine from aniline using the Friedel-Crafts condensation reaction. This process requires a catalyst such as aluminum chloride (AlCl3) or iron (III) chloride (FeCl3) and an appropriate alkylating agent like methyl chloride (CH3Cl) or ethyl chloride (C2H5Cl).
2. Regulation of Toluidine
o-toluidine, m-toluidine, and p-toluidine are all regulated under various regulatory laws as hazardous substances, poisonous and deleterious substances, and inflammable liquids.
List of 9 Toluidine Manufacturers
*Including some distributors, etc.
Sort by Features
- Default
- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- India
- Japan
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KANTO CHEMICAL CO.,INC.
p-Toluidine
Manufacturer Overview
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
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Aarti Industries Limited
Toluidine
Manufacturer Overview
Aarti Industries Limited (AIL) is a global manufacturer of speciality chemicals and pharmaceuticals based in India. They were founded in 1984 and provide services to the chemical industry's 700+ domestic clients as well as 400+ international clients. Chemical products produced by Aarti Industries are used in the production of pharmaceuticals, agrochemicals, polymers, additives, and dyes. They started out as an Indian company serving international markets and now they are a worldwide organization with manufacturing facilities in India.
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Merck
p-Toluidine
Manufacturer Overview
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
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MilliporeSigma
p-Toluidine
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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nacalai
p-Toluidine
Company Overview
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
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Central Drug House
p-Toluidine
Company Overview
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
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Shree Sai Life Sciences
P-toluidine
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Otto Chemie Pvt. Ltd
p-Toluidine
Distributor Overview
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
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Anant Pharmaceuticals Pvt. Ltd.
4-TOLUIDINE
Distributor Overview
Anant Pharmaceuticals Pvt. Ltd., established in 2005, is a supplier of pharmaceutical impurity reference samples and custom synthesis and analytical services, based in India. The company delivers novel solutions to research and development teams. Their organic synthesis labs are equipped with modern equipment, designed with energy saving concept. Over the years, they have developed into a one-stop service provider for bespoke chemical synthesis and analytical services for a wide range of industries in India and abroad.
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Toluidine Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Aarti Industries Limited |
62.5%
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| 2 | Central Drug House |
12.5%
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| 3 | Anant Pharmaceuticals Pvt. Ltd. |
12.5%
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| 4 | Otto Chemie Pvt. Ltd |
12.5%
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Derivation Method
The ranking is calculated based on the click share within the toluidine page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- KANTO CHEMICAL CO.,INC.: 1,062
Newly Established Company
- Shree Sai Life Sciences: 2011 (13 years ago)
- Anant Pharmaceuticals Pvt. Ltd.: 2005 (19 years ago)
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
Company with a History
- nacalai: 1934 (90 years ago)
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- Anant Pharmaceuticals Pvt. Ltd.: 2005 (19 years ago)
Global Distribution of Toluidine Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
India
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4 | 66.7% |
Japan
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2 | 33.3% |
