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This section provides an overview for phenothiazine as well as their applications and principles. Also, please take a look at the list of 13 phenothiazine manufacturers and their company rankings. Here are the top-ranked phenothiazine companies as of December, 2024: 1.KANTO CHEMICAL CO.,INC., 2.WeylChem International GmbH, 3.ChemDiv.
Table of Contents
Phenothiazine, with the chemical formula C12H9NS, is a heterocyclic compound characterized by two benzene rings fused to thiazine. Known also as "10H-Phenothiazine" or "dibenzothiazine," it serves as the backbone for various derivatives with diverse applications.
Phenothiazines find use in various fields such as insecticides, treatment of urinary tract infections, polymerization inhibitors, antioxidants, dyes, and notably in antipsychotics like chlorpromazine and promethazine, which are effective in treating schizophrenia and other conditions.
This compound is a pale yellow crystalline powder at room temperature, with a melting point of 185.1℃ and boiling point of 371℃. It's easily soluble in acetone, slightly in ethanol, and insoluble in water, exhibiting stability yet susceptible to oxidation and light exposure.
Available as reagents in various quantities such as 25g, 500g, and 1kg, phenothiazine and its derivatives are crucial in research and development. It is necessary to comply with laws and regulations in its handling and storage.
Synthesis involves melting diphenylamine with sulfur and a catalyst, producing hydrogen sulfide as a byproduct.
Light exposure causes phenothiazine to oxidize and darken, leading to various oxidized products. It decomposes under heat or acidic conditions, releasing toxic substances.
Derivatives include methylene blue and various antipsychotics like promazine, chlorpromazine, and promethazine, each having specific applications in medical treatments.
Noted risks include skin and respiratory irritation, potential damage to major organ systems, and high toxicity to aquatic life, necessitating careful handling per regulatory standards.
*Including some distributors, etc.
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ChemScence, LLC., established in 2006, is an American manufacturer based in Monmouth Junction, New Jersey, specializing in building blocks and fine research chemicals. The company offers approximately 45,000 building blocks and intermediates, as well as thin layer chromatography, screening libraries, bioactive small molecules, and isotope compounds. ChemScence also provides dye and biochemical assay reagents, peptides, and natural products like glycosides, and steroids. Catering to a diverse clientele including universities, research institutions, as well as pharmaceutical and biotechnology companies, ChemScence extends its services to include custom chemistry solutions. Furthermore, the company offers technical expertise in the domain of new drug development.
AccuStandard, established in 1986 and headquartered in New Haven, Connecticut, USA, is a manufacturer of Certified Reference Materials (CRMs). The offered products include organic standards, inorganic standards, custom standards, proficiency testing materials, and calibration kits. These products are used to ensure the accuracy, precision, and reliability of analytical methods and instruments in various industries such as environmental, pharmaceutical, food, petrochemical, and forensic. Its products meet stated specifications and comply with international standards, including ISO 17034:2016, ISO/IEC 17025:2017, and ISO 9001:2015.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
WeylChem International GmbH is a German-based manufacturer and supplier of fine chemicals that was established in 2005 and headquartered in Frankfurt am Main. The company offers a diverse range of specialty products and custom manufacturing solutions, serving industries such as pharmaceuticals, agrochemicals, and electronics. WeylChem International GmbH’s product portfolio includes Home Care and I&I Cleaning, which develops bleach activators and catalysts, surfactants, soil release polymers and builders. The company also provide services such as analytical services, contract development and custom synthesis.
BLDpharm was founded in 2014 and headquartered in Shanghai, China is a manufacturer and supplier of various research chemicals. The company offers a wide range of laboratory chemicals including heterocycles, boron acids, amino acids, metal catalysts, and chiral compounds. These quality products find an array of applications as inhibitors for metabolic enzymes, pharmaceutical intermediates for antipsychotic drugs, catalysts for chiral resolving reagents, and material science for OLED material and synthesis intermediates.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | KANTO CHEMICAL CO.,INC. |
37.5%
|
| 2 | WeylChem International GmbH |
16.7%
|
| 3 | ChemDiv |
8.3%
|
| 4 | BLDpharm |
8.3%
|
| 5 | AccuStandard |
4.2%
|
| 6 | ChemScence |
4.2%
|
| 7 | BOC Sciences |
4.2%
|
| 8 | Junsei Chemical Co.,Ltd. |
4.2%
|
| 9 | FUJIFILM Wako Pure Chemical Corporation |
4.2%
|
| 10 | nacalai |
4.2%
|
Derivation Method
The ranking is calculated based on the click share within the phenothiazine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
5 | 55.6% |
|
United States of America
|
3 | 33.3% |
| United States | 1 | 11.1% |
