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This section provides an overview for dabco as well as their applications and principles. Also, please take a look at the list of 9 dabco manufacturers and their company rankings. Here are the top-ranked dabco companies as of December, 2024: 1.Fengchen Group Co.,Ltd, 2.Otto Chemie Pvt. Ltd, 3.Merck.
Table of Contents
DABCO is a white crystalline powder of tertiary amines.
Its IUPAC name is 1,4-diazabicyclo [2,2,2] octane, also known as 1,4-ethylenepiperazine, DABCO, and TEDA.
DABCO is a registered trademark (No. 551479) of Air Products & Chemicals, Inc. DABCO is not subject to any major national regulations.
DABCO is mainly used as a catalyst for polyurethanation reactions. It is dissolved in crystalline form or with diprovylene glycol, etc., and the polyaddition reaction and the foaming reaction proceed in a well-balanced manner. Soft, hard, semi-hard, urethane paints and urethane elastomers can be produced.
DABCO is used as a bulky base in small-molecule organic synthetic chemical reactions. A well-known example of its use is the Morita-Baylis-Hillman reaction. DABCO is a nucleophilic catalyst in the reaction.
When aldehydes or imines react with alkenes substituted with electron-withdrawing groups in the presence of DABCO, new carbon-carbon bonds are formed. The reaction proceeds by a Michael-Aldol-like mechanism.
In addition, it is used as a catalyst for metal complex salt formation, dehalogenation agent, cyanoethylation catalyst, ester exchange catalyst, and epoxy resin curing catalyst.
The chemical formula is C6H12N2 and the molecular weight is 112.17. The CAS number is 280-57-9.
Its melting point is 158 °C and its boiling point is 174 °C. It is hygroscopic and sublimates and exists as a solid at room temperature. The compound has an ammonia-like odor and is well soluble in water, ethanol, acetone, and chloroform.
It has a pH of 10.8, which indicates the degree of acidity or alkalinity, and acid dissociation constants (pKa) of 3.0 and 8.6. The acid dissociation constant is a quantitative measure of the strength of an acid; a smaller pKa indicates a stronger acid.
The basicity of DABCO is comparable to other tertiary amines, but it has high nucleophilicity due to its fixed structure, which leaves unshared electron pairs exposed.
DABCO is synthesized by cyclization of amine compounds using zeolite as a catalyst. Ethylenediamine,monoethanolamine, diethanolamine, and diethylenetriamine can be used as amine compounds.
Handling Precautions
Avoid contact with strong oxidizing agents. There is a risk of respiratory irritation. Use in a draft chamber with local exhaust ventilation. Wear personal protective equipment when using.
In Case of Fire
Thermal decomposition may release corrosive and toxic gases and vapors. Use water spray, foam, powder extinguisher, carbon dioxide, or extinguishing sand to extinguish fire.
For Storage
DABCO may be altered by light. During storage, place in polypropylene or polyethylene containers and seal tightly. Store locked up in a well-ventilated and as cool a place as possible, away from direct sunlight.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Fengchen Group Co., LTD is based in Qingdao, China. The company is a manufacturer and supplier of speciality chemicals for several industries around the world including natural resources, hydrogeology, drilling, geophysics, and environmental & geotechnical services. The company’s chemical product categories include APIs, amino acids, micronutrients, package materials, and enzymes. The company also offers services including specialized transportation, samples of compounds, shipping documents needed for pharmaceutical products, and international customs support.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Fengchen Group Co.,Ltd |
20.8%
|
| 2 | Merck |
16.7%
|
| 3 | Otto Chemie Pvt. Ltd |
12.5%
|
| 4 | Junsei Chemical Co.,Ltd. |
12.5%
|
| 5 | KANTO CHEMICAL CO.,INC. |
12.5%
|
| 6 | Green View Technology and Development Co., Ltd. |
8.3%
|
| 7 | Kishida Chemical Co.,Ltd. |
8.3%
|
| 8 | Central Drug House |
4.2%
|
| 9 | nacalai |
4.2%
|
Derivation Method
The ranking is calculated based on the click share within the dabco page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
4 | 57.1% |
|
India
|
2 | 28.6% |
China
|
1 | 14.3% |
