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This section provides an overview for triethylenetetramine as well as their applications and principles. Also, please take a look at the list of 10 triethylenetetramine manufacturers and their company rankings. Here are the top-ranked triethylenetetramine companies as of December, 2024: 1.KANTO CHEMICAL CO.,INC., 2.Junsei Chemical Co.,Ltd., 3.Sisco Research Laboratories Pvt. Ltd..
Table of Contents
Triethylenetetramine (TETA) is an organic compound, a primary amine with the chemical formula C6H18N4.
It is also known as 3,6-diazaoctane-1,8-diyl diamine and trientine. It has a molecular weight of 146.23, a melting point of 12 °C, a boiling point of 266–267 °C, and appears as a colorless to slightly light yellow liquid at room temperature.
It has a density of 0.982 g/mL and is extremely soluble in water and soluble in ethanol and acetone.
Triethylenetetramine is utilized as an anti-wrinkle agent, surfactant, and dye-fixing agent in textile products. It is also widely used as a curing agent in epoxy resins, paper wet-strengthening agent, fungicide, insecticide, herbicide, chelating agent, coating agent, adhesive, fungicide additive in lubricants and cutting oils, ion exchange resin, and rubber chemicals (vulcanization accelerator).
Furthermore, triethylenetetramine dichloride serves as a chelating agent for copper, promoting urinary excretion of copper, and is used in treating Wilson's disease, a disorder of copper metabolism.
Triethylenetetramine is synthesized by heating a mixture of ethylenediamine or ethanolamine and ammonia over an oxide catalyst. This synthetic method yields a variety of amines, including triethylenetetramine.
Triethylenetetramine is a colorless, oily liquid that turns yellow when old due to impurities from air oxidation, a common characteristic of many amines. Commercial samples may contain branched isomers tris(2-aminoethyl)amine and piperazine.
Primarily sold as a reagent product for research and development, triethylenetetramine is available in 10 mL, 25 mL, 50 mL, and 500 mL volumes, facilitating easy handling in laboratory conditions.
Note that some products are sold as ethyleneamine mixtures.
As a tetradentate ligand in coordination chemistry, known as triene, triethylenetetramine is particularly recognized for its selective chelating action on copper (II). It forms M (trien) L2-type octahedral complexes and can assume various diastereomeric structures.
Triethylenetetramine hydrochloride is effective in treating Wilson's disease, where inorganic copper accumulates due to metabolic disorders. It is specifically administered for patients with a poor response to penicillamine or for whom administration is undesirable.
Various hydrochlorides of triethylenetetramine, including dihydrochloride and tetrahydrochloride, are used in different countries as specific treatments.
With a flash point of 138 °C, triethylenetetramine is classified under various regulatory laws and should be treated to reduce its hazardous level before disposal.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Sisco Research Laboratories Pvt. Ltd., established in 1975, is an Indian manufacturer and supplier of chemicals, biochemicals, and reagents, headquartered in Mumbai, Maharashtra. Supported by Food and Drug Administration (FDA)-approved manufacturing facilities, the company offers a range of products, including general laboratory chemicals and solvents, biochemical, bioreagents, and specialty fine chemicals. Their offerings also include animal cell culture, BioLit™ range of DNA and protein tools, and nanotechnology products. Additionally, SRL provides dehydrated culture media, biological ingredients, media supplements, chromogenic media, and media kits. These products serve diverse industries such as biotechnology, confectionary and food, personal care products, pharmaceuticals, and protein purification.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Nouryon has a history dating back to 1646 Sweden but was officially formed in 2018 after gaining independence from AkzoNobel. The company is a manufacturer of everyday consumer products including personal care and cleaning goods, as well as products for the agricultural, pharmaceutical, and building industries. The company’s brands include Dissolvine, Witbreak, Butanox, and Ferrazone. These brands manufacture products across five product segments: Bleaching and Oxidizing Chemicals and Technologies, Specialty Polymers, Surfactants and Chelating Agents, Polymer Production and Processing Chemicals, and Specialty Chemicals and Intermediates.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Delamine B.V. was established in 1908 and is headquartered in Amersfoort The Netherlands, and manufactures and supplies in shipbuilding, road construction, the automotive industry, customer products, paint, healthcare, and even toilet paper, tea bags, or diapers powered by delamines. The portfolio of the company consists of EDA, N-AEP - N, DETA, TEPA, TETA, and many more. The company operates as an EDC-based manufacturer. From the company’s headquarters and own production plant in the Netherlands, the company exports ethylene amines to well over 50 countries globally. And it interacts with more than 15 different strategic markets.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | KANTO CHEMICAL CO.,INC. |
22.2%
|
| 2 | Junsei Chemical Co.,Ltd. |
14.3%
|
| 3 | Sisco Research Laboratories Pvt. Ltd. |
12.7%
|
| 4 | Nouryon |
11.1%
|
| 5 | Kishida Chemical Co.,Ltd. |
9.5%
|
| 6 | Tokyo Chemical Industry Co., Ltd. |
8.7%
|
| 7 | nacalai |
8.7%
|
| 8 | Delamine B.V. |
6.3%
|
| 9 | Biosynth |
3.2%
|
| 10 | Merck |
3.2%
|
Derivation Method
The ranking is calculated based on the click share within the triethylenetetramine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
5 | 62.5% |
|
India
|
1 | 12.5% |
|
Switzerland
|
1 | 12.5% |
|
Netherlands
|
1 | 12.5% |
