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This section provides an overview for tetramethylsilane as well as their applications and principles. Also, please take a look at the list of 25 tetramethylsilane manufacturers and their company rankings. Here are the top-ranked tetramethylsilane companies as of December, 2024: 1.American Elements, 2.WEINERT industries AG, 3.Molport.
Table of Contents
Tetramethylsilane (TMS), an organosilicon compound, has the molecular formula Si(CH3)4 or SiMe4. With a CAS number of 75-76-3, TMS is a clear colorless liquid at room temperature, characterized by its petroleum odor. It has a molecular weight of 88.23, a melting point of -152°F, a boiling point of 79.9°F, and a density of 0.648 g/cm3. TMS is extremely soluble in ethanol and diethyl ether, but almost insoluble in water. It is highly flammable and should be handled with care, being stable under normal conditions but reactive with strong oxidizers, acids, and bases.
Tetramethylsilane is mainly used as an internal standard in NMR spectroscopy and as a precursor for silicon dioxide and silicon carbide in chemical vapor deposition (CVD). In NMR, TMS's NMR peak shifts significantly towards the low-frequency side, making it ideal for use as a reference material. It is chemically unreactive, highly volatile, and easily removable post-NMR measurement. In CVD, TMS serves as a precursor to silicon dioxide or silicon carbide, depending on the growth conditions.
In the lab, TMS is synthesized by reacting chlorotrimethylsilane or silicon tetrachloride with methylmagnesium bromide in dry dibutyl ether, followed by purification.
TMS can react with n-butyl lithium to form Si(CH3)3CH2Li, used as an alkylation reagent. It is also a byproduct in the formation of methylchlorosilane from the reaction of chloromethane and silicon.
Sold primarily as a chemical reagent, TMS is available in various volumes for use in biochemistry, NMR measurements, and as an internal standard reagent. Due to its low boiling point, it requires refrigeration for storage.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
American Elements was founded in 1997 in California and currently has research and production facilities in Utah, Mexico, China, and the United Kingdom. AE manufactures and distributes advanced materials from a catalog of over 30,000 products for bulk industrial use as well as small scale laboratory use. AE also provides testing and analyses services including spectroscopy along with structural, thermal, and electrical analyses. AE holds sustainable development as a core corporate value and is committed to work to protect the health of the environment.
Cambridge Isotope Laboratories (CIL) established in 1981, is a global supplier of stable isotopes and labeled compounds, headquartered in the United States. The company provides of products for research, environmental analysis, and medical applications.Their comprehensive product offerings include isotopically labeled standards, biochemicals, and gases, catering to many industries and scientific communities, with partnerships worldwide. They specializes in the process of labeling biochemical and organic compounds with highly enriched, stable (nonradioactive) isotopes of carbon, hydrogen, nitrogen and oxygen.
Gelest Inc., founded in 1991, and headquartered in Glen Rock, Pennsylvania, is a manufacturer, and supplier of high-growth materials and science-intensive applications. Their diverse product range includes silanes, used to modify surface properties; silicones; metal-organics for creating metal-containing compounds; and acrylates for acrylic polymer production. These chemicals are utilized in manufacturing adhesives, sealants, coatings, elastomers, lubricants, as well as surfactants, catalysts, pigments, and more. Gelest has established a Quality Management System that is certified according to the ISO 9001 standard, and Responsible Care 14001 Certification.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
CPAChem Ltd, founded in 2001 and based in Bogomilovo, Bulgaria, is a manufacturer of organic and inorganic custom-made certified reference materials as well as pharmacopoeia products and Analytical CRMs. With the capability to produce more than 200 different products daily, it stands as the sole global producer offering products in accordance with seven different pharmacopoeias, including the Japanese, Indian, and British pharmacopoeias. The company boasts a catalog of over 9,000 stock products, serving clients such as Carlo Erba, Fisher, and VWR. It holds ISO 9001 certification and has achieved accreditation in ISO/IEC 17025 and ISO 17034.
CHEM-LAB NV, established in 1993, and located in Zedelgem, Belgium, is a manufacturer of reagents for diverse applications. The company offers high-purity NIST-traceable organic and inorganic standards, laboratory reagents, and CRMs for various analytical methods. Its products find applications in environmental science, water resources, food and beverage, manufacturing, and waste monitoring. Certified with ISO 9001:2000, ISO 17034, and ISO 17025, the company maintains quality standards in the production of Certified Reference Standards and Reagents.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
WEINERT Industries AG is a manufacturer of fiber optic solutions and special components, founded in 2021 and headquartered in Neuhaus-Schierschnitz, Germany. The company offers ultrapure fused silica, preforms, and rods, as well as optical fibers, cables, assemblies, polishing discs and films, and various accessories. It also provides fiber manufacturing and engineering, development and consulting, and fiber services. The company has a global distribution network spanning Europe, America, Asia, the Middle East, and Africa. It serves the transportation, marine, data communications and network, optical metrology, and healthcare sectors.
Strem Chemicals, Inc, founded in 1964, is an American manufacturer and supplier of high-purity specialty chemicals and materials, based in Newburyport, Massachusetts. Acquired by Ascensus Specialties, another American chemical company in 2021, Strem offers a catalog of over 6,000 specialty products under the metal, inorganic, organometallic, and nanomaterial categories. Some of their diverse product offerings include metal catalysts for organic synthesis, metal carbonyls, metal organic chemical vapor deposition (MOCVD) and atomic layer deposition (ALD) precursors. Strem serves global customers, particularly academic, governmental, and industrial research and development laboratories. Their products find applications in various industries, including microelectronics, chemicals, petrochemicals, and pharmaceuticals.
LEAP CHEM Co., Ltd. is a manufacturer and supplier of chemical products established in 2005 and headquartered in Hong Kong, China. The company offers an extensive range of about 200,000 chemical products, including organic compounds, inorganic compounds, pharmaceutical intermediates, and custom synthesis services. Their products cater to industries such as pharmaceuticals, agrochemicals, electronics, and materials. LEAP CHEM provides chemical solutions and services to its global customers, supporting research, development, and production activities. Additionally, they provide custom synthesis and contract research, sourcing, online orders of small quantities, global supply chain and export, and technical support services.
Electron Microscopy Sciences, established in 1974, is a supplier of scientific products and services, based in the United States. The company specializes in providing instruments, consumables, and chemicals for electron microscopy and histology, and they are the most comprehensive source for all fields of microscopy, histology and general laboratory research. Their network spans over 50 countries, catering to research institutions, universities, and industries worldwide. Notable achievements include strong partnerships with major manufacturers, ensuring top-notch offerings for customers.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Fisher Scientific UK Ltd is a supplier of laboratory chemicals, equipment, and services based in Loughborough, United Kingdom, operating as a subsidiary of Thermo Fisher Scientific, a merger of Fisher Scientific International, Inc. and Thermo Electron in 2006. With a portfolio of over 2 million products, Fisher Scientific offers chemicals, reagents, equipment and instruments, consumables, and safety products. These products cater to various sectors, including clinical diagnostic and research laboratories, pharmaceutical and biotech industries, healthcare, and government agencies. Fisher Scientific also provides business solutions like the New-Lab Start-Up program, as well as SureTRACE and SureTRACE+ for product knowledge and supply chain management.
G&H Distributing Inc. is a hydraulic and industrial hose stocking distributor founded in 1946 and headquartered in South Dakota, US. The company distributes air and water hoses, discharge hoses, suction hoses, pressure water hoses and parts, and hose menders. It also offers a wide range of adapters, clamps, couplers, crimping machines, and valves. The company is a certified hydraulic hose and fitting assembler, serving OEMs and providing maintenance and repair services in the United States. It caters to the agriculture, food and beverage, construction, manufacturing, and MRO industries.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | American Elements |
10.5%
|
| 2 | WEINERT industries AG |
7.9%
|
| 3 | Molport |
7.9%
|
| 4 | CPAChem |
7.9%
|
| 5 | Alfa Aesar, Thermo Fisher Scientific. |
7.9%
|
| 6 | CHEM-LAB NV |
5.3%
|
| 7 | Gelest Inc. |
5.3%
|
| 8 | Central Drug House |
5.3%
|
| 9 | LEAP CHEM Co., Ltd. |
5.3%
|
| 10 | Electron Microscopy Sciences |
5.3%
|
Derivation Method
The ranking is calculated based on the click share within the tetramethylsilane page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
5 | 29.4% |
|
Japan
|
4 | 23.5% |
|
United Kingdom
|
2 | 11.8% |
|
Bulgaria
|
1 | 5.9% |
|
Belgium
|
1 | 5.9% |
|
Germany
|
1 | 5.9% |
France
|
1 | 5.9% |
|
India
|
1 | 5.9% |
China
|
1 | 5.9% |
