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This section provides an overview for semicarbazide as well as their applications and principles. Also, please take a look at the list of 42 semicarbazide manufacturers and their company rankings. Here are the top-ranked semicarbazide companies as of December, 2024: 1.Tokyo Chemical Industry Co., Ltd..
Table of Contents
Semicarbazide, a urea derivative with the molecular formula CH5N3O, is a versatile organic compound used in various applications, from thin-layer chromatography to organic synthesis, including the production of nitrofuran antimicrobials.
As a chromogenic reagent and paint hardener, semicarbazide aids in identifying aldehydes and ketones through the formation of semicarbazones, leveraging its reaction with carbonyl compounds to form highly crystalline imine derivatives.
It serves as an intermediate in synthesizing antimicrobial agents, highlighting its significance in pharmaceuticals.
A colorless crystalline solid, semicarbazide is soluble in water and ethanol, showcasing a melting point of 96°C and a molecular weight of 75.07.
Available primarily as a reagent or industrial chemical in hydrochloride salt form, semicarbazide caters to diverse needs from research to large-scale industrial applications.
Semicarbazide is synthesized through reactions involving urea and hydrazine, among other methods, underlining its chemical versatility.
Its ability to form semicarbazone through condensation with carbonyl compounds is a key feature, aiding in the identification of various substances.
Commonly utilized in its hydrochloride form for organic synthesis, semicarbazide hydrochloride embodies the compound's adaptability in chemical processes.
*Including some distributors, etc.
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AK Scientific, Inc. (AKS) is an American advanced intermediates and fine chemicals manufacturer that was established in Union City, California in 1997. The company’s product lineup includes chemical biocides, bioactives, inhibitors, and reagents. It also offers a range of products for use in life science applications, such as screening compounds, organoborons, and molecular fluorophores. These are extensively used in agrochemicals, biotech, pharmaceuticals, and nanotechnology. Aside from its products, AKS also offers international procurement and sourcing services to its clients, which include AstraZeneca, Sanofi-Aventis, and Bristol-Myers Squibb.
Smolecule Inc., founded in 2020 and headquartered in San Antonio, Texas, USA, is a manufacturer specializing in small-molecule compounds that are essential to biomedical research and pharmaceutical discovery. The company offers an array of products, including carbon nanomaterial, hydrophobic polymers, biological buffers, amino acids resin and reagents, and amino acid peptide and protein standards. These compounds have applications across various scientific disciplines, including material sciences, pharmaceutical and biopharmaceutical manufacturing, analytical chemistry, protein biology, and chemistry and biochemical research.
ChemScence, LLC., established in 2006, is an American manufacturer based in Monmouth Junction, New Jersey, specializing in building blocks and fine research chemicals. The company offers approximately 45,000 building blocks and intermediates, as well as thin layer chromatography, screening libraries, bioactive small molecules, and isotope compounds. ChemScence also provides dye and biochemical assay reagents, peptides, and natural products like glycosides, and steroids. Catering to a diverse clientele including universities, research institutions, as well as pharmaceutical and biotechnology companies, ChemScence extends its services to include custom chemistry solutions. Furthermore, the company offers technical expertise in the domain of new drug development.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
BenchChem, an American company located in Pasadena, California, is a supplier specializing in chemicals and biochemicals for laboratory and research and development use. The company’s product portfolio includes inhibitors, chemical reagents, bioactive chemicals, lead compounds, and catalysts. These products cater to various industries, including pharmaceutical companies, biotechnology firms, academic and research institutions, chemical and materials science researchers, as well as environmental and analytical laboratories. The company provides customer services, including contract manufacturing and analytical services.
Haoyuan Chemexpress Co., Ltd., founded in 2009 and based in Shanghai, China, is a manufacturer of customized chemical synthesis. The company specializes in customized synthesis of complex small molecule frameworks and pharmaceutical intermediates. It is also involved in independent R&D of new drugs, and provides services of production technology improvement and consigned new drug development for pharmaceutical enterprises. It develops APIs and pharmaceutical intermediates with high synthesis technology barriers and works on the synthesis of chiral compounds. The company's premises include a synthesis laboratory which is able to develop 20 varieties of new drugs at the same time.
CLEARSYNTH, founded in 2009 and based in Mumbai, India, is a manufacturer of chemical research products. The company specializes in organic chemistry and synthesis of complex molecules, stable Isotope labelled compounds, metabolites, glucuronides and radioactive labelled compounds. It also offers custom synthesis of complex Molecules or compounds/Intermediates. The company is an ISO 9001:2008, 14001:2004 & 18001:2007 certified manufacturer with research & development centers in India and Canada, and a clientele in 80 countries across 5 continents.
Zhengzhou Alfa Chemical Co., Ltd. (ZACC) is a manufacturer of organic chemicals and catalysts established in 2010 and based in Jiaozuo, Henan. The company primarily produces pharmaceutical and organic intermediates as well as photoelectric materials for customers in life science, polymers, dyes, and metallurgy. The company's product lineup includes condensed ring compounds, heterocyclic compounds, COFS/MOFS, and metal catalysts. These supply client corporations such as Bayer AG, Pfizer Inc., and Sumitomo Chemical Company, Ltd. ZACC also offers gram- to ton-level contract synthesis and production services.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Wuhan Fortuna Chemical Co., Ltd., established in 2006 and headquartered in Wuhan, China, is a manufacturer that engaged in organic and fine chemical products, laboratory chemicals, and chemical wholesale products. The company offers a range of products, including flunixin meglumine, amitraz, sodium hyaluronate, carprofen, and cottonseed oil. It also provides custom-tailored products according to client's requirements. Its Antioxidant 245 has low volatility, which means it does not evaporate easily. The company has achieved ISO9001 and GMP certification. Its products are exported to South Korea, Vietnam, Australia, Europe, and South America.
Sisco Research Laboratories Pvt. Ltd., established in 1975, is an Indian manufacturer and supplier of chemicals, biochemicals, and reagents, headquartered in Mumbai, Maharashtra. Supported by Food and Drug Administration (FDA)-approved manufacturing facilities, the company offers a range of products, including general laboratory chemicals and solvents, biochemical, bioreagents, and specialty fine chemicals. Their offerings also include animal cell culture, BioLit™ range of DNA and protein tools, and nanotechnology products. Additionally, SRL provides dehydrated culture media, biological ingredients, media supplements, chromogenic media, and media kits. These products serve diverse industries such as biotechnology, confectionary and food, personal care products, pharmaceuticals, and protein purification.
Sarna Chemicals PVT. LTD., established in 1989 and based in Gujarat, India, is a manufacturer of dye intermediates, pigment intermediates, and specialty chemicals. The company produces products such as Bisphenol amino sulfonyl ester, 3,4 Dimethoxyaniline, 2-Nitro Dimethyl terephthalate, and Meta nitro benzoyl Chloride, and two of its manufacturing units abide by ISO-9001, ISO-14001 and OHSAS-18001. Apart from this, the company also makes products according to customer requirements and quality parameters. The company is also awarded with the export house by the Foreign Trade Policy of the Ministry of Commerce and Industry, Government of India.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Japan Finechem Co.,Inc. manufactures fine and speciality chemicals and industrial electronic components. The company was founded in Tokyo, Japan in 1959 and presently employs 272 employees overall Japan. Their product portfolio for chemicals includes organic and inorganic chemicals, intermediates for food additives and pharmaceuticals, agricultural chemicals and feed additives. In the electronic components sector they manufacture electric machinery equipment and parts such as resistors and resistor boxes. They also produce high voltage measuring devices such as digital meters, probes and dividers. These products are mainly used in industrial equipments, chemical measuring instruments, X-ray apparatuses and electron microscopes.
Veeprho, established in 2011 and headquartered in Praha, Czech Republic, is a manufacturer of industrial chemicals. It is a chemical research company involved in the research, development, and supply of synthesized impurities, metabolites, intermediates, and active pharmaceutical ingredients (APIs) through custom synthesis. These products are utilized in the global pharmaceutical industry. Its global network is comprised of manufacturing and R&D facilities in India, as well as distribution offices in New Jersey US, and United Kingdom equipped to provide immediate support within all time zones.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
SAGECHEM, founded in 2009 and located in Hangzhou, China, is a manufacturer and distributor of chemical R&D. The company’s broad range of products includes aminopeptides, APIs and intermediates, carbohydrates, ionic liquids, and organosilicon. These products play essential roles in pharmaceutical research, drug development, and biotechnology for creating therapeutic compounds and biopharmaceuticals. These chemicals are employed in chemical R&D to explore new materials, chemical reactions, and advanced materials in materials science. The company’s chemicals cater to industries such as agriculture, environmental science, and energy-related research and are used in an array of scientific and industrial settings.
FUJIFILM Wako Pure Chemical Corporation, established in 1922 and headquartered in Osaka, Japan, is a manufacturer and supplier of laboratory chemicals, specialty chemicals, and diagnostic reagents. Its product range encompasses Azo Polymerization Initiators, Photo-Initiators, Polymerization Inhibitors, Resin Modifiers, and Pharmaceutical and Cosmetic Materials, which find applications in diverse fields like research, and testing. The company operates multiple manufacturing facilities in Aichi, Harima, Tokyo, and the USA, with its adherence to quality exemplified by its ISO/IEC 17025 certification.
MainChem Co., Ltd, established in 2014, is a Chinese manufacturer and distributor of fine and specialty chemicals, with its headquarters located in Xiamen, Fujian. The company's product portfolio includes life science chemicals, petrochemicals, and specialty chemicals. Some of MainChem’s chemical substances have passed evaluations based on Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH), a European Union regulation. These chemicals are used in various industries, including cosmetics, food additives, personal care product, and water treatment. MainChem offers the "ONE-STOP" solution for chemical sourcing from China. They also provide custom chemical synthesis services, encompassing the entire process from initial research to commercial-scale production.
HPC Standards GmbH, established in 1996, is a manufacturer and distributor of high-purity analytical standards for residue analysis, located in Germany. The company specializes in the manufacture of reference materials for pesticides, veterinary products, and their metabolites and stable isotope-labelled derivatives. They are ISO 9001 certified and accredited according to ISO 17034. Their products are tested according to international quality requirements and meet the highest industrial standards. They serve as a competent partner in the fields of food and environmental analysis with a wide range of products, including dyes, food-related chemicals, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and polymer additives.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Carl Roth GmbH + Co. KG, established in 1879 and headquartered in Karlsruhe, Germany, is a manufacturer, distributor, and supplier of laboratory equipment, life science products, and chemicals. Their extensive product range encompasses analytical instruments, biological safety cabinets, heating mantles, pH meters, centrifuges, thermometers, and various chemicals. Their products support and facilitate laboratory research, analysis, and experimentation across various industries such as pharmaceutical, chemical, and environmental sectors. The company is certified according to DIN EN ISO 9001:2015 and DIN EN ISO 14001:2015.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Merck Millipore, founded in 1954 and headquartered in Darmstadt, Germany, is a manufacturer, distributor, and supplier of life science products and services. Their diverse range of products finds applications in research, development, and manufacturing of biotechnological and pharmaceutical drug therapies. Some of their offerings include filters for removing contaminants from liquids and gases, chromatography columns for separating and analyzing complex mixtures, reagents used in various laboratory assays, antibodies for detecting and quantifying specific molecules, and cell culture media for growing and maintaining cells in culture. Their products and services are utilized significantly in the advancement of life sciences and drug development.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
APExBIO Technology LLC is a distributor and supplier of molecular biology tools based in Houston, Texas, United States. The company's product portofolio includes various products such as small molecule inhibitors, compound libraries, fluorescent labels, modified nucleotides, and assay kits. The products are used in various areas such as cancer, immunology, neurosciences, apoptosis, and epigenetics researches. The company offers various supporting services such as analytical services, custom organic synthesis, custom peptide synthesis, and bioinformatics services.
Yuanfar International Trade Company, established in 2001 and headquartered in Xi'an, Shaanxi, China, is a distributor of nonferrous metals, chemicals, and solar-photovoltaic products while providing professional foreign trade supply chain services. Its product range includes chemicals like Hydrazine hydrate, Mono-methyl hydrazine, DMF, Acetonitrile, and Fluorine products, serving diverse industries and exporting to countries such as Europe, the USA, India, and Japan. With two decades of experience, the company has cultivated strong partnerships with chemical companies in China, contributing to global trade.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
CliniSciences, founded in 1991 and based in Nanterre, France, is a distributor of reagents and instruments for immunology, cell biology and molecular biology. The company's product range includes reagents, consumables, instruments and biological samples applicable in areas such as immunology, oncology, plant research, and much more. It has a team of scientists across Europe that visit customers' laboratories to discuss their specific needs and offer tailor-made solutions. The company has acquired ISO 13485:2016 certification, and provides services like technical support & training, biodegradable packaging and centralized logistics.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Discovery Fine Chemicals, founded in 2006 and based in Dorset, UK, is a supplier of biochemicals and life science products. The company provides antibiotics, APIs, buffers, carbohydrates, detergents & enzyme substrates for microbiology, diagnostics, research and production. It has a portfolio of nearly 600 compounds comprising antibiotics, antibacterials and antifungals that are held in stock in pack sizes ranging from 10mg up to multi kilo packs. The company's products are ISO 9001-2015 certified, and are meant to be used in microbiology, food microbiology, public health, universities and diagnostics.
ChemSrc, established in 2014, is a supplier of pharmaceutical products, a chemical database platform, and a search engine. This platform serves as a gateway to an extensive repository of chemical knowledge, offering access to unique CAS-encoded product records including synthesis routes, literature references, physical and chemical properties, and supplier information. The chemical catalog spans various categories, including organic raw materials, dyes and pigments, chemical pesticides, catalysts, additives, and more. The repository information plays a vital role in supporting research and development efforts across diverse industries by fostering scientific advancements and serving as a valuable resource.
MuseChem Chemicals is an American chemical supplier located in Fairfield, New Jersey. They offer a wide range of products, including inhibitors and agonists, active pharmaceutical ingredients (APIs), and specialty chemicals. Research chemicals such as chemical reagents, bioactive chemicals, catalysts, and ligands are also part of their product offerings. MuseChem provides various services, including custom synthesis research of organic compounds for the agrochemical, chemical, and pharmaceutical industries. They also offer peptide synthesis services, ranging from bulk API peptides production to complex peptide modifications. Moreover, MuseChem offers bioconjugation services to create functional biomolecules for biomarker imaging, protein biodistribution, and cellular event tracking.
HAZMAT Resource, Inc., located in Irvine, California, USA, is a distributor of hazardous materials response equipment and materials. They specialize in personal protective equipment (PPE), testing devices, and technical reference materials for hazardous materials (hazmat) response. Their product range includes PPE such as suits, gloves, boots, and respirators to safeguard hazmat responders from dangerous substances. They offer various testing devices like meters, detectors, and kits for precise identification and measurement of hazardous materials. Additionally, the company provides technical reference materials like books, manuals, and software, equipping responders with essential knowledge on hazardous material properties and safe handling procedures.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Tokyo Chemical Industry Co., Ltd. |
100.0%
|
Derivation Method
The ranking is calculated based on the click share within the semicarbazide page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
8 | 23.5% |
|
India
|
7 | 20.6% |
|
China
|
6 | 17.6% |
|
Japan
|
5 | 14.7% |
|
United Kingdom
|
3 | 8.8% |
|
Germany
|
2 | 5.9% |
| United States | 1 | 2.9% |
|
Canada
|
1 | 2.9% |
|
France
|
1 | 2.9% |
