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This section provides an overview for oleamide as well as their applications and principles. Also, please take a look at the list of 12 oleamide manufacturers and their company rankings. Here are the top-ranked oleamide companies as of December, 2024: 1.SINO SUNMAN INTERNATIONAL, 2.Parchem, 3.Nantong Dongli New Material Technology Co., Ltd..
Table of Contents
Oleic acid amide is an amide of oleic acid, an unsaturated fatty acid.
It is also known as "oleamide." Its molecular formula is C18H35NO, and it contains one amide bond and one double bond. In living organisms, oleamide is produced endogenously from oleic acid by the biosynthesis of oleic acid and ammonia.
Like oleic acid, it is said to be related to sleep-related neuropeptides. The synthesis pathway and the enzymes required for biosynthesis have not yet been identified, and the substance is still under study.
It is industrially produced and used for a variety of applications. It is a solid substance with low toxicity and skin sensitization, but it is irritating to the eyes and should be carefully rinsed out if it gets into the eyes.
Oleamide and other fatty acid amides have long-chain hydrocarbon groups that are highly lipophilic and amide groups that are highly hydrophilic, which allows them to function on a variety of material surfaces.
Oleamide is often used as a lubricant for polyolefin resins, such as polyethylene and polypropylene. Lubricants are additives that reduce friction between resin pellets or molded products, or between resins and processing machines.
In the case of polyethylene film, the addition of approximately 0.1% to 0.5% oleamide is generally sufficient to achieve the desired effect. Other industrial applications include ink dispersants, wax modifiers, metal defogging, rust inhibitors, and synthetic raw materials for other chemicals.
Oleamide has been found in a variety of foods, the most familiar of which is Camembert cheese. It is also found in other foods, such as Taiso, which is used as a herbal medicine.
Although it has not yet reached the stage of practical application, it has been shown to work on sleep and stress, and its application as a therapeutic agent for sleep disorders and depression is under consideration. Oleamide is thought to exhibit anti-inflammatory activity while activating cells called microglia, which are responsible for removing waste products such as amyloid-β in the brain.
Other uses of oleamide itself are rare, but its derivatives are used as raw materials for shampoos and cosmetics as detergents, foam stabilizers, penetrating agents, wetting agents, and emulsifying aids, taking advantage of its surfactant properties.
Oleamide is industrially produced by the reaction of oleic acid and ammonia in the presence of a catalyst. First, ammonium oleate is formed, which is dehydrated under high pressure to form oleamide.
Boric acid, activated alumina, silica gel, and kaolin are effective catalysts. The reaction conditions are 170 to 200°C, pressure 0.3 to 0.7 MPa, and reaction time 10 to 12 hours.
The raw material oleic acid is not limited, but plant-derived oleic acid can be manufactured with less odor than animal-derived oleic acid due to differences in impurities. Another method is to react an oleic acid ester with ammonia. In this case, fats and oils are used as raw materials, and glycerin can be recovered.
Oleamide is sold mainly as reagent products for research and development, and as powders, flakes, and particles for industrial use. In reagent products, it is sold in reagent bottles with contents of 25g or 500g, which is an easy size to handle in the laboratory. They can be stored at room temperature.
For industrial use, it is sold in large packages for lubricant applications in plastic factories.
*Including some distributors, etc.
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Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Connect Chemicals USA, LLC is a producer, custom manufacturer and distributor of specialty chemicals that was established in 1998 and is headquartered in Ratingen, Germany. The company has a US subsidiary that is based in Houston, Texas. The company’s products include a wide range of specialty chemicals, including solvents, adhesives, coatings, and lubricants. Its products are used by several industries, as diverse as cosmetics, pharmaceuticals, and food and beverage. The company also offers a wide range of services, including custom manufacturing, formulation, and packaging.
Polymer Chemical Ltd., established in 2020 and headquartered in Haiphong City, Vietnam, is a manufacturer and supplier of specialty chemicals for the polymer industry. The company is a comprehensive chemical enterprise integrating petrochemical, coal chemical, and biochemical industries. It specializes in producing a diverse range of additives, intermediates, modifiers, and compounds used in the production and processing of polymers. The company’s products find applications in industries such as plastics, rubber, and composites manufacturing. The company is partnered with other companies in Mexico, USA, and Russia.
SINO SUNMAN INTERNATIONAL was founded in 2018 in Anhui, China, and is a supplier of raw materials such as resins, pigment, and additives for the printing ink, plastic, coating, and painting industries. It supplies resins like cellulose acetate butyrate, vinyl chloride MP, maleic acid, water-based solid acrylic, and hot melt adhesive to the following countries: South Asia, the Middle East, North America, Africa, and Korea. The company also distributes pigments like Bronze gold powder, glow-in-the-dark, and reflective powder.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | SINO SUNMAN INTERNATIONAL |
14.5%
|
| 2 | Parchem |
12.8%
|
| 3 | Nantong Dongli New Material Technology Co., Ltd. |
11.1%
|
| 4 | POLYMER CHEMICAL LTD |
10.3%
|
| 5 | Cayman Chemical Company |
10.3%
|
| 6 | MilliporeSigma |
8.5%
|
| 7 | Sichuan Tianyu Oleochemical Co., Ltd |
7.7%
|
| 8 | KANTO CHEMICAL CO.,INC. |
7.7%
|
| 9 | Glentham Life Sciences Limited |
6.8%
|
| 10 | Qingdao Sainuo New Material Co., Ltd. |
5.1%
|
Derivation Method
The ranking is calculated based on the click share within the oleamide page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
China
|
3 | 37.5% |
|
United States of America
|
2 | 25.0% |
|
Japan
|
2 | 25.0% |
|
United Kingdom
|
1 | 12.5% |
