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This section provides an overview for allopurinol as well as their applications and principles. Also, please take a look at the list of 4 allopurinol manufacturers and their company rankings. Here are the top-ranked allopurinol companies as of December, 2024: 1.APExBIO Technology LLC, 2.Tokyo Chemical Industry Co., Ltd., 3.SRL.
Table of Contents
Allopurinol is a xanthine oxidase inhibitor used in treating hyperuricemia and gout. By inhibiting uric acid production in the body, it improves hyperuricemia and prevents gout attacks.
Allopurinol is primarily used as an antidepressant for hyperuricemia. It is typically taken orally at doses of 200 mg to 300 mg per day, divided into two to three doses. However, early stages of use may trigger gout attacks as uric acid crystals are expelled from the joints.
Common side effects include rash, itching, joint pain, anemia, abnormal liver function, anorexia, soft stools, diarrhea, fatigue, and hair loss. Since allopurinol is eliminated through the kidneys, dosage adjustments are necessary in cases of impaired kidney function.
Allopurinol has the chemical formula C5H4N4O, a molecular weight of 136.112 g/mol, and is structurally related to hypoxanthine. It appears as a white crystalline powder, soluble in ammonia reagent but insoluble in water and ethanol. In the body, it is metabolized to oxypurinol, which has a longer half-life and contributes to the drug's efficacy.
Studies have shown that allopurinol may reduce cardiovascular events and improve kidney function. It has also been associated with regression of left ventricular hypertrophy in Type 2 diabetic patients. However, it has been implicated in cases of Stevens-Johnson syndrome and toxic epidermal necrolysis.
Hypoxanthine, a structural isomer of allopurinol, is a purine derivative found in nucleic acids. It is metabolized to inosinic acid via the salvage pathway, playing a role in nucleic acid synthesis.
*Including some distributors, etc.
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TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
APExBIO Technology LLC is a distributor and supplier of molecular biology tools based in Houston, Texas, United States. The company's product portofolio includes various products such as small molecule inhibitors, compound libraries, fluorescent labels, modified nucleotides, and assay kits. The products are used in various areas such as cancer, immunology, neurosciences, apoptosis, and epigenetics researches. The company offers various supporting services such as analytical services, custom organic synthesis, custom peptide synthesis, and bioinformatics services.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | APExBIO Technology LLC |
55.3%
|
| 2 | Tokyo Chemical Industry Co., Ltd. |
21.3%
|
| 3 | SRL |
14.9%
|
| 4 | nacalai |
8.5%
|
Derivation Method
The ranking is calculated based on the click share within the allopurinol page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
2 | 66.7% |
|
India
|
1 | 33.3% |
