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  4. Cultured cardiomyocyte activity measuring device CIOS8 (Brainvision Inc.)
Cultured cardiomyocyte activity measuring device CIOS8-CIOS8
Cultured cardiomyocyte activity measuring device CIOS8-Brainvision Inc.

Cultured cardiomyocyte activity measuring device CIOS8
Brainvision Inc.

About This Product

■Summary

Myocardial cell activity stain-free measuring device CIOS8. Just place the culture plate on this device. It is possible to measure the activity of cardiomyocytes in culture without staining and non-invasively. The measurement results are displayed in real time as a waveform, and the pulsation period and contraction time are automatically detected with the touch of a button. Built-in temperature control and plate movement mechanism. It is small and lightweight, making it ideal for personal use.

■Usage example

・Counting the number of beats of cultured cardiomyocytes (no staining) ・Measurement of contraction time of cultured cardiomyocytes (no staining) ・Simple measurement of action potential using voltage-sensitive dye ・Confirmation of differentiation of iPS-derived cardiomyocytes ・Cardiotoxicity testing of new drug candidates

■Main features

・Automatic detection of heart muscle cell pulsation and contraction time without using fluorescent dyes or electrodes ・By using the built-in fluorescence filter, simple membrane potential measurement using membrane potential sensitive dyes such as Di-4-ANEPPS is also possible.

■Measurement method and principle

The measurement principle of this device is very simple. A light-emitting diode placed on the underside of the sample illuminates the sample brightly and obliquely. It is well known to researchers in the field of optical measurement in biophysics that cellular activity is accompanied by changes in light scattering, and it is known that contraction of the heart muscle produces a relatively large signal. The reflected light component is received by a photodiode, and only the changing component is amplified by a high-power amplifier and extracted. This signal is sent to a digital processing circuit via an ADC, which magnifies the slightest optical change by a factor of several thousand to tens of thousands of times, and performs numerical processing to identify it as myocardial activity.

■Structure of CIOS8

・Light source, light receiving section, signal processing circuit, and temperature control stage are all built into the main body. ・Electric well plate carrier The plate was moved left and right without opening the lid, and 96 wells were measured in 3 rows (24 wells) at the same time 4 times. Cardiomyocyte activity can be measured under stable conditions.

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    Cultured cardiomyocyte activity measuring device CIOS8

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1 Models of Cultured cardiomyocyte activity measuring device CIOS8

Image Part Number Price (excluding tax) Power supply Weight Temperature control Composition Detected items Recommended usage environment Compatible culture plate Size Culture plate movement mechanism Product name Control PC Interface
Cultured cardiomyocyte activity measuring device CIOS8-Part Number-CIOS8

CIOS8

Available upon quote

DC24V 1A x 2 (for main unit, for heater)

Approximately 1kg

Automatic

CIOS8 main unit, USB2.0 cable, AC adapter x2, control software

Beat rate, contraction time

Temperature range: 20℃~30℃, humidity range: 30%~80%

Size of 96 wells or less (compatible with cell culture plates from various companies)

Width 185mm x depth 115mm x height 75mm

Electric

Myocardial cell activity dye-free measuring device CIOS8

Windows 7/10 64-bit OS recommended

USB2.0

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About Company Handling This Product

Brainvision Inc.

Company Overview

Brainvision Inc., founded in 1998 and based in Tokyo, Japan, is a manufacturer of brain science equipment. Th...

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