13 Phosphonic Acid Manufacturers in 2024
This section provides an overview for phosphonic acid as well as their applications and principles. Also, please take a look at the list of 13 phosphonic acid manufacturers and their company rankings. Here are the top-ranked phosphonic acid companies as of November, 2024: 1.BroadPharm, 2.Junsei Chemical Co.,Ltd., 3.KANTO CHEMICAL CO.,INC..
Table of Contents
What Is Phosphonic Acid?
Figure 1. Basic Information on Phosphonic Acid
Phosphonic acid is an oxoacid of phosphorus with an oxidation number of +3, and chemical formula of H3PO3.
It has a molecular weight of 82.00 g/mol and a density of 1.65 g/cm3. Phosphonic acid is obtained through the hydrolysis of phosphorus trichloride. In solution, it exhibits tautomerism with phosphorous acid.
In organophosphorus chemistry, phosphonic acid refers to a series of compounds with the general formula RR-P(=O)(OH)2, where R represents an organic group.
Uses of Phosphonic Acid
Phosphonic acid possesses strong reducing properties and serves as a reducing agent in electroless plating. Silver and copper can be plated from aqueous solutions of silver nitrate and copper sulfate, respectively.
P-alkylphosphonate dialkyl esters (R-P(=O)(OR')2) are significant intermediates in industry. They are known as Horner-Emmons reagents and are utilized as raw materials for alkenes, fragrances, and pharmaceuticals.
Properties of Phosphonic Acid
Phosphonic acid melts at 70.1°C and appears as colorless, odorless crystals. Upon heating to 200°C, it decomposes into phosphine and phosphoric acid
It is insoluble in water, except for its alkali and calcium salts. The acid dissociation constants are pKa = 1.5 and 6.79.
Structure of Phosphonic Acid
Figure 2. Structure of Phosphonic Acid
The formula of phosphonic acid is HP(=O)(OH)2. The presence of the P-H bond is confirmed by physical measurements, indicating the formation of only mono- and di-substituted salts, with no trisubstituted salts being produced. The molecule is tetrahedral in shape.
Phosphonic acid exists in tautomeric equilibrium with phosphorous acid. In this equilibrium, phosphonic acid predominates.
In organophosphorus chemistry, phosphonic acid broadly refers to compounds containing a phosphorus-hydrogen bond and a phosphoryl group, including various organic derivatives such as alkyl phosphonic acids.
Other Information on Phosphonic Acid
1. Synthesis of Organic Phosphonic Acid
Figure 3. Synthesis of Organic Phosphonic Acid
Organic phosphonic acids are derivatives in which a hydrogen atom on the phosphorus atom is substituted with an alkyl group. Examples include methylphosphonic acid (CH3P(O)(OH)2) and phenylphosphonic acid (C6H5P(O)(OH)2).
Trialkyl phosphite esters undergo isomerization, transferring an alkyl group from the oxygen to the phosphorus atom, producing alkylphosphonic acid dialkyl esters through the Michaelis-Arbuzov Reaction.
2. Reaction of Phosphonic Acid
Phosphonic acid's reactivity, especially that of the P-H bond, is leveraged for synthesis. Aminophosphonates, obtained through the Kabachnik-Fields or Pudovik reactions, serve as valuable chelating agents. Industrially, nitrilotris (methylene phosphonic acid) is synthesized.
Alkylation of phosphonic acid with an acrylic acid derivative via Michael addition produces a phosphonic acid bearing a carboxy group.
List of 13 Phosphonic Acid Manufacturers
*Including some distributors, etc.
Sort by Features
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- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- Germany
- Japan
- United Kingdom
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BroadPharm
PEG3-bis(phosphonic acid)
Manufacturer Overview
BroadPharm, founded in San Diego, CA, in 2009 is a manufacturer of PEG Linkers, Click Chemistry reagents and Bio-labeling reagents such as Dye Labeling and Biotin Labeling. The company's product portfolio includes Lipids In Drug Delivery, Fluorescent Dye, Biotinylation Reagents, Dye Antibody Labeling Kit and Biotin Antibody Labeling Kit. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare.
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KANTO CHEMICAL CO.,INC.
Phosphonic acid
Manufacturer Overview
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
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Junsei Chemical Co.,Ltd.
Phosphonic Acid
Manufacturer Overview
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
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Kishida Chemical Co.,Ltd.
Phosphonic Acid
Manufacturer Overview
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
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LGC Standards
Phosphonic Acid
Manufacturer Overview
LGC Standards Ltd., established in 1842, is a global British manufacturer and supplier of reference standards, headquartered in Teddington, Middlesex, with offices in 20 countries worldwide. As a subsidiary of LGC Group, the United Kingdom’s National Measurement Institute, LGC Standards also serves as the Government Chemist, providing expert opinions based on independent chemical and bioanalytical measurements. Under the business unit LGC Industrial, the company offers industrial measurement tools. Additionally, their subsidiaries, including Toronto Research Chemicals Inc (TRC) of Canada, LGC Mikromol™, and Dr. Ehrenstorfer™ of Germany, develop research tools, standards for pharmaceutical quality control, and reference materials for food and environmental analysis.
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Tokyo Chemical Industry Co., Ltd.
(4-Aminobenzyl)phosphonic Acid
Manufacturer Overview
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
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Merck
Phosphorous acid
Manufacturer Overview
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
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Strem Chemicals, Inc
Phosphonic Acid
Manufacturer Overview
Strem Chemicals, Inc, founded in 1964, is an American manufacturer and supplier of high-purity specialty chemicals and materials, based in Newburyport, Massachusetts. Acquired by Ascensus Specialties, another American chemical company in 2021, Strem offers a catalog of over 6,000 specialty products under the metal, inorganic, organometallic, and nanomaterial categories. Some of their diverse product offerings include metal catalysts for organic synthesis, metal carbonyls, metal organic chemical vapor deposition (MOCVD) and atomic layer deposition (ALD) precursors. Strem serves global customers, particularly academic, governmental, and industrial research and development laboratories. Their products find applications in various industries, including microelectronics, chemicals, petrochemicals, and pharmaceuticals.
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MilliporeSigma
(Aminomethyl)phosphonic acid
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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nacalai
Phosphonic Acid
Company Overview
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
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Alfa Aesar, Thermo Fisher Scientific.
Phosphonic Acid
Company Overview
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
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HPC Standards GmbH
Phosphonic Acid
Company Overview
HPC Standards GmbH, established in 1996, is a manufacturer and distributor of high-purity analytical standards for residue analysis, located in Germany. The company specializes in the manufacture of reference materials for pesticides, veterinary products, and their metabolites and stable isotope-labelled derivatives. They are ISO 9001 certified and accredited according to ISO 17034. Their products are tested according to international quality requirements and meet the highest industrial standards. They serve as a competent partner in the fields of food and environmental analysis with a wide range of products, including dyes, food-related chemicals, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and polymer additives.
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BOC Sciences
Phosphonic acid
Company Overview
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
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Phosphonic Acid Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | BroadPharm |
20.0%
|
| 2 | Junsei Chemical Co.,Ltd. |
20.0%
|
| 3 | KANTO CHEMICAL CO.,INC. |
20.0%
|
| 4 | LGC Standards |
10.0%
|
| 5 | Kishida Chemical Co.,Ltd. |
10.0%
|
| 6 | Strem Chemicals, Inc |
5.0%
|
| 7 | HPC Standards GmbH |
5.0%
|
| 8 | Tokyo Chemical Industry Co., Ltd. |
5.0%
|
| 9 | MilliporeSigma |
5.0%
|
Derivation Method
The ranking is calculated based on the click share within the phosphonic acid page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- KANTO CHEMICAL CO.,INC.: 1,062
- Kishida Chemical Co.,Ltd.: 283
- Junsei Chemical Co.,Ltd.: 171
Newly Established Company
- BroadPharm: 2009 (15 years ago)
- Strem Chemicals, Inc: 1964 (60 years ago)
- Junsei Chemical Co.,Ltd.: 1948 (76 years ago)
Company with a History
- nacalai: 1934 (90 years ago)
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- Tokyo Chemical Industry Co., Ltd.: 1946 (78 years ago)
Phosphonic Acid Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Phosphonic Acid Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
Japan
|
5 | 55.6% |
United Kingdom
|
2 | 22.2% |
United States of America
|
1 | 11.1% |
Germany
|
1 | 11.1% |
