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This section provides an overview for phenethylamines as well as their applications and principles. Also, please take a look at the list of 5 phenethylamine manufacturers and their company rankings. Here are the top-ranked phenethylamine companies as of December, 2024: 1.BOC Sciences, 2.Spectrum Chemical Mfg. Corp., 3.nacalai.
Table of Contents
Phenethylamine is an organic compound with C6H5(CH2)2NH2 and C8H11N.
It is an alkaloidal monoamine with the IUPAC nomenclature 2-phenylethanamine and other names such as β-phenylethylamine and 2-phenethylamine.
The CAS registration number is 64-04-0. Although the names are very similar, it should be noted that 1-phenylethylamine (also known as α-phenylethylamine, CAS No. 98-84-0) is a different compound.
The main use of phenethylamine is as a flavoring agent. It is registered as a food additive. In Europe and the United States, phenethylamine is used in processed foods, especially in baked goods, gelatin/puddings, meat products, soft candies, frozen dairy products, soft drinks, etc. Phenethylamine is also used as a flavor enhancer in various processed foods.
Phenethylamine is also believed to function as a neuromodifier and neurotransmitter in the human brain. Because of their structural similarity to monoamine neurotransmitters, many of their derivatives, substituted phenethylamines, are known to possess pharmacological activity.
For this reason, a group of derivatives of phenethylamine are used as drugs and medicines or as intermediate raw materials for pharmaceuticals. Phenethylamine derivatives with pharmacological activity include hypoallergenics, bronchodilators, and antidepressants in pharmaceuticals, and stimulants, hallucinogens, and empathogens in illicit drugs.
Phenethylamine has a molecular weight of 121.18, a melting point of -60°C, and a boiling point of 198°C. It is a clear colorless to yellowish brown liquid at room temperature. It has a fishlike odor, a pH of 11.5 (4.3 g/L, 20°C), and a density of 0.962 g/mL (20°C).
It is extremely soluble in ethanol, diethyl ether, and acetone, and soluble in water. It has a flash point of 90°C (tag sealed) and should be treated as a highly flammable liquid and vapor.
It is also known to react with carbon dioxide (CO2) to form carbonates when exposed to air.
Phenethylamine is typically sold as a reagent product for R&D/pilot studies. The types of volumes include 25mL, 50mL, 100mL, and 500mL. This reagent product can be stored at room temperature due to its stable compounds.
Since hydrochloride is a solid, hydrochloride salt is sometimes used for ease of handling. This chemical is also commonly sold as a reagent product.
Various compounds with chemical modifications in the phenyl group, side chain, and amino group are known as phenethylamine derivatives. For example, amphetamine, a drug with indirect adrenergic receptor stimulating effects (clinically applicable in the United States and other countries, but not in Japan), is a derivative with a α-methyl group adjacent to the amino group on the side chain.
Methamphetamine, widely used in Japan for drug abuse, is a derivative of amphetamine with a methyl group substituted on the nitrogen atom. Phenethylamine derivatives with hydroxy groups on the third and fourth positions of the phenyl group are classified as catecholamines, and include the transdermal substances levodopa, dopamine, noradrenaline, and adrenaline.
The aromatic amino acids of phenylalanine and tyrosine are also phenethylamine derivatives with a carboxyl group at the α-position.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | BOC Sciences |
33.3%
|
| 2 | Spectrum Chemical Mfg. Corp. |
25.0%
|
| 3 | nacalai |
16.7%
|
| 4 | Merck |
16.7%
|
| 5 | KANTO CHEMICAL CO.,INC. |
8.3%
|
Derivation Method
The ranking is calculated based on the click share within the phenethylamine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
2 | 66.7% |
|
United States of America
|
1 | 33.3% |
