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This section provides an overview for triethylamine hydrochloride as well as their applications and principles. Also, please take a look at the list of 32 triethylamine hydrochloride manufacturers and their company rankings. Here are the top-ranked triethylamine hydrochloride companies as of December, 2024: 1.City Chemical LLC., 2.Molekula Americas LLC, 3.Actylis.
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1993~2019: Engaged in pharmaceutical research and development and analysis of various biological samples at the Pharmaceutical Research Institute of Japan Kayaku Co., Ltd. He is also in charge of facility management as a dangerous goods handler and radiation handling chief.
2019: Moved to another company in the same industry and has been in charge of similar work until now.
He also writes, translates, and edits specialized books.
Linkedin: https://www.linkedin.com/in/makoto-niwa-25331040/
Researchmap: https://researchmap.jp/0000-0002-2355-1222/
Triethylamine hydrochloride is a salt (ammonium salt) formed when triethylamine, a strongly basic organic amine (tertiary amine), is reacted with hydrochloric acid.
The original triethylamine is a liquid that mixes with organic solvents, while the hydrochloride salt is a solid that is highly water soluble. Also known as triethylammonium chloride, its chemical formula is (C2H5)3N - HCl and its CAS number is 554-68-7.
It is usually present as a white solid and is characterized by a slight amine odor.
Triethylamine hydrochloride is mainly used as a raw material for organic synthesis of pharmaceuticals and dyes. For example, triethylamine is liberated using a strong base, which is then reacted with other molecules. It is also used as an ion-pair reagent in ion-pair extraction, in which an aggregate is formed with an acidic substance and extracted into an organic solvent (ion-pair extraction), because it has three hydrophobic ethyl groups and is a strong base.
As in extraction, it can also be used in ion-pair high-performance liquid chromatography (HPLC). As in extraction, ion-pair reagents are used to form ion pairs by associating with acidic substances to allow analysis of water-soluble acidic substances by reversed-phase HPLC. However, tetraethylammonium hydrochloride, a quaternary ammonium salt that is more effective in HPLC, is increasingly being used.
In liquid chromatography-mass spectrometry (LC-MS), where volatility is important, more volatile reagents, such as triethylamine acetate are sometimes used. Triethylamine Hydrochloride is relatively inexpensive compared to these ion-pair reagents. It is also used as a comparison reagent for sodium chloride in biochemical experiments to study the effects of sodium ions because of its weakly acidic to neutral liquid properties.
Triethylamine hydrochloride is a white solid (crystalline or crystalline powder). It is soluble in water and ethanol, but not in ether. It is particularly soluble in water.
Aqueous solutions range from near neutral to slightly acidic, with a pH of 3.0-6.0 at a concentration of 50 g/L. Its melting point is not considered definite, and it decomposes at about 260°C when heated.
The powder is tidally soluble, so care should be taken with humidity when storing and handling. In addition, light shielding is essential when storing the product, as it may be altered by light.
Triethylamine Hydrochloride is produced by chemical synthesis. It is generally synthesized by alkylating ammonia with ethanol to obtain triethylamine, which is then converted to hydrochloride.
It is known to be corrosive and irritating to skin, severely damaging to eyes, and irritating to eyes.
However, as a general precaution for chemical substances, dust-protective masks and protective gloves should be worn and the product should be handled in an environment with local exhaust ventilation. It is also important to avoid mixing with strong oxidizers, as they react violently.
In the event of a fire, complete combustion produces carbon dioxide and nitrogen oxides, and simultaneously hydrogen chloride gas. Thermal decomposition may also generate amine and ammonia, both of which are harmful to the human body.
Triethylamine hydrochloride may produce triethylamine. Because triethylamine is harmful to the aquatic environment, disposal of triethylamine hydrochloride must also be conducted in such a way that there is no environmental release.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
City Chemical LLC. was founded in 1997 and is a manufacturer and supplier of chemical products based in West Haven, Connecticut, United States. The company's product portofolio includes ammonium fluoride, silicon acetate, potassium manganate, silicon bromide, and barium cyanide. The products are used in various industries such as military, aerospace, semiconductor, and research and development. The MOCVD, CVD, and ALD products lineup are used in the semiconductor sectors for producing micro and nano electronics thin films.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Actylis is based in Port Washington, New York, USA, and is an ISO 13485-certified custom manufacturer of chemical compounds that was established in 1978 as a subsidiary of Aceto. The company mainly produces specialty chemical products for the pharmaceutical, biopharm, and agriscience sectors. These chemical products include cell culture ingredients, active pharmaceutical ingredients (APIs), and buffering salts. It also offers excipients, adenosine for cosmetic ingredients, and vitamins for nutritional supplements. The company operates internationally, with manufacturing facilities in Germany, the United Kingdom, and India. Some of its notable clients include Novartis, Nestlé, and Estée Lauder.
Merck KGaA was founded in 1668 and is a manufacturer of medical products and devices based in Darmstadt, Germany. The company manufactures various products such as erbitux, bavencio, tepmetko, glucophage, and eutyhrox. These products are used for various purposes such as general medicine treatments, cardiovascular diseases, childhood growth hormone deficiency, multiple sclerosis treatments, and merkel cell carcinoma. The company has obtained various certifications such as ISO 9001:2015, ISO 14001:2015, ISO 45001:2018, and ISO 50001:2018.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Hangzhou Dayangchem Co.Limited is a manufacturer and supplier of fine chemicals and pharmaceutical intermediates, headquartered in Hangzhou, Zhejiang, China. Its product range covers organic compounds, Active Pharmaceutical Ingredients (APIs), nutritional products, and custom synthesis. Some of its products are heterocyclic compounds, aromatic compounds, boronic acids, amino acids, and organometallic compounds. These products are used for developing various drugs, agrochemicals, dyes, flavors, and fragrances for different markets such as pharmaceutical, biotechnology, cosmetic, and food industries. The company holds ISO 9001:2008 certification for its quality management system.
Apollo Scientific Ltd, a subsidiary of Japan’s Central Glass Europe Limited, is a research chemicals manufacturer and supplier founded in 1993 and headquartered in Bredbury, United Kingdom. Performing chemical syntheses in their Manchester-based laboratories, Apollo Scientific offers a selection of over 100,000 chemical products, from fluorinated compounds to non-fluorinated building blocks, for research and industry applications. Their life science products include antibiotics and buffers, as well as customized products for stem cell, molecular biology, and proteomics research. Additionally, Apollo Scientific offers spectroscopy products, such as consumables for infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry standards.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Omega Finechem Private Limited, incorporated on 2009, is a manufacturer and supplier organization based in Boisar, Maharashtra. The company specialize in Drug Intermediates & Fine Chemicals tailored to clients' specifications, the company boasts products with features such as high purity, accurate composition, precise pH, effectiveness, and applications. With an authorized share capital of INR 1.00 lac and total paid-up capital of INR 1.00 lac, Omega Finechem remains actively engaged in the industry. The company is headquartered in Boisar, Maharashtra, and its directors include Sandhya Shashikant Dhamorikar and Aniket Shashikant Dhamorikar. Omega Finechem's delivering chemical solutions is reflected in its continuous growth
SAMUH LAXMI CHEMICALS is a manufacturer of speciality chemicals that was founded in 1996 and is headquartered in Mumbai, India. Its main activity is the production of speciality chemicals, including flame retardants, stabilizers, and emulsifiers. The product range includes antimony salts, fine chemicals, foundry chemicals, industrial chemicals, and industrial peroxides. The company also offers a wide range of services, such as custom synthesis, formulation, and packaging. SAMUH LAXMI CHEMICALS' products are used by a wide range of customers, including the laboratories, organic and inorganic chemical industries, rubber industries, and agrochemical industries.
Arran Chemical Company Ltd. is a manufacturer of products for specialized chemical and industrial applications, founded in 1984 and headquartered in Roscommon, Ireland. The company offers specialized reaction technology, including organometallic synthesis, catalytic transfer hydrogenation, and various operations required for chiral compound synthesis. Its product line consists of pharmaceutical intermediates, flavor and fragrances, personal care products, and chiral amino acids. The company holds ISO 9001:2015 and ISO 14001:2015 certifications. It is part of the Almac Group, a global pharmaceutical and contract development and manufacturing organization.
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
Henan Tianfu Chemical Co., Ltd., founded in 2009, is a Chinese chemical manufacturer and supplier based in Zhengzhou, Henan. The company has developed over 500 compounds, mostly for fine applications in manufacturing and life science. Their product range includes electronic chemicals, ultraviolet (UV)-curing materials, ionic liquids, and pharmaceutical materials. Additionally, Henan Tianfu has expanded into the fine chemical market, offering noble metal catalysts, organic phosphine ligands, and organic light-emitting diode (OLED) intermediates. They are also involved in the development of pesticides and medical intermediates, as well as the analysis and synthesis of electronic chemical materials.
Avantor was founded in 1904 and is headquartered in Radnor, Pennsylvania, as a supplier of lab and production services such as general and technical lab services, production, and business process consulting services. The company offers various clinical services, including customized kitting solutions, clinical trial equipment, and ancillary services. The organization is regarded as a dependable global partner for customers and suppliers in the life sciences, advanced technologies, and applied materials industries, spanning from initial discovery to final delivery.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Ralington Pharma LLP, founded in Gujarat in 2015, India is a manufacturer of pharmaceutical products such as chemicals, natural extracts and pellets. The company's product portfolio includes Active Pharma Ingredients, Specialty Pharmaceuticals, and Generic Pharmaceuticals. The company serves industries such as healthcare, pharmacies, clinical research, and Chemical and Petrochemicals. The company offers customer services that include support, custom research projects and customized services. The company also have microbiological testing services for products and pharmaceutical water, antimicrobial effectiveness tests and method suitability tests.
Hunan Huateng Pharmaceutical Co. Ltd., established in 2013 and based in Changsha, China, is a supplier of PEG derivatives and a contract manufacturer of APIs and intermediates. It stocks chemical reagents, vaccine excipients, APIs, and pharmaceutical intermediates, among other chemicals. In 2016, the company launched the first R&D center in Changsha, and in 2020, it completed the construction of its company, which started operations. It is ISO 9001 certified and has a range of facilities to manufacture and store chemical products up to 10 Metric Tons.
Hemanshu Chemicals was established in 1990 in Maharashtra, India, and is a manufacturer and supplier of chemicals, solvents, and pharmaceuticals that are used to make a wide range of products, such as food additives, paints, adhesives, and lubricants. The company makes chemical products like Dexamethasone sodium phosphate, Beclomethasone dipropionate, Magnesium hydroxide IP, and Benzoyl chloride. It also imports Magnesium hydroxide, 4- Hydroxybenzaldehyde, Magaldrate, and hydroxybenzaldehyde from countries such as Korea, China, and Taiwan.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Alkyl Amines Chemicals Limited (AAC) is an Indian supplier of amine derivatives and specialty products that was established in Navi Mumbai, Maharashtra in 1979. The company produces various aliphatic amines such as propylamines and cyclohexylamines, as well as amine derivatives (e.g. nitriles, oximes). It also offers specialty chemicals for niche applications, including tertiary and chiral amines. Aside from its products, AAC also offers contract manufacturing and custom synthesis services to its clients, which mainly consists of companies in the petrochemical, rubber, agrochemical, and textile industries.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Watson International Limited, founded in 1996, and headquartered in London, England, is a professional fine chemical supplier. The company is capable in the development of both natural and unnatural amino acids, along with amino alcohols. Additionally, it offers custom synthesis services for carbohydrates, including carbohydrate-based intermediates, carbohydrate-based drugs, and glycosidase substrates. As the business department of the FCAD Group, the company serves as a crucial intermediary between research and development (R&D), production, and market demand. Leveraging the research and development capacity of FCAD, it caters to several industries, including pharmaceuticals, healthcare, electronics, and personal care.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | City Chemical LLC. |
40.0%
|
| 2 | Molekula Americas LLC |
20.0%
|
| 3 | Actylis |
20.0%
|
| 4 | Alfa Chemistry |
10.0%
|
| 5 | Spectrum Chemical Mfg. Corp. |
10.0%
|
Derivation Method
The ranking is calculated based on the click share within the triethylamine hydrochloride page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
11 | 42.3% |
|
United States of America
|
4 | 15.4% |
|
Japan
|
3 | 11.5% |
|
China
|
2 | 7.7% |
|
United Kingdom
|
2 | 7.7% |
|
Germany
|
1 | 3.8% |
| United States | 1 | 3.8% |
|
Ireland
|
1 | 3.8% |
Switzerland
|
1 | 3.8% |
