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This section provides an overview for trimethylsilane as well as their applications and principles. Also, please take a look at the list of 13 trimethylsilane manufacturers and their company rankings. Here are the top-ranked trimethylsilane companies as of December, 2024: 1.City Chemical LLC., 2.Gelest Inc., 3.Pharmaffiliates.
Table of Contents
Trimethylsilane is an organosilicon compound with the chemical formula C3H10Si and CAS number 993-07-7. It is a colorless gas at room temperature, nearly odorless or with a faintly unpleasant odor. It has a molecular weight of 74.2, a melting point of -135.9 °C, a boiling point of 6.7 °C, a density of 0.638 g/cm³, and a specific gravity of 2.6, making it heavier than air. Its solubility is not well defined, but it does not react violently with water.
Trimethylsilane has a flash point below -20 °C, making it highly flammable. It ignites at room temperature but is not spontaneously combustible.
Trimethylsilane's primary use is in semiconductor manufacturing, particularly as a raw material for film deposition in low-k dielectric constant interlayer insulating film formation using the plasma CVD method. It is utilized for SiC, SiOC, SiO2, and SiN film materials.
Purification is crucial for its use in semiconductor production, with typical impurities including methylsilane, dimethylsilane, silane, and unreacted chlorosilane. Common purification methods include distillation, recrystallization, reprecipitation, sublimation, activated carbon filtration, and washing with an absorption solution in the pH range of 2 to 4.
Trimethylsilane is synthesized primarily by reducing trimethylchlorosilane ((CH3)SiCl) using agents such as lithium aluminum hydride (LiAlH4) in DME or aromatic hydrocarbon solvents, lithium hydride (LiH), or diethylaluminum hydride ((C2H5)2AlH).
At room temperature and atmospheric pressure, trimethylsilane is stable but may decompose to silicon carbide and hydrogen at temperatures above 500 °C. It is a flammable gas, igniting at room temperature with an ignition point of 310 °C. Proper handling to avoid fire and static electricity is necessary.
Trimethylsilane is available as high-pressure and liquefied gas products, mainly for industrial use. Storage requires keeping the container below 40 °C, in a dry, well-ventilated area away from direct sunlight. As a flammable gas, it must be stored away from fire and combustible materials.
*Including some distributors, etc.
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Gelest Inc., founded in 1991, and headquartered in Glen Rock, Pennsylvania, is a manufacturer, and supplier of high-growth materials and science-intensive applications. Their diverse product range includes silanes, used to modify surface properties; silicones; metal-organics for creating metal-containing compounds; and acrylates for acrylic polymer production. These chemicals are utilized in manufacturing adhesives, sealants, coatings, elastomers, lubricants, as well as surfactants, catalysts, pigments, and more. Gelest has established a Quality Management System that is certified according to the ISO 9001 standard, and Responsible Care 14001 Certification.
City Chemical LLC. was founded in 1997 and is a manufacturer and supplier of chemical products based in West Haven, Connecticut, United States. The company's product portofolio includes ammonium fluoride, silicon acetate, potassium manganate, silicon bromide, and barium cyanide. The products are used in various industries such as military, aerospace, semiconductor, and research and development. The MOCVD, CVD, and ALD products lineup are used in the semiconductor sectors for producing micro and nano electronics thin films.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
Apollo Scientific Ltd, a subsidiary of Japan’s Central Glass Europe Limited, is a research chemicals manufacturer and supplier founded in 1993 and headquartered in Bredbury, United Kingdom. Performing chemical syntheses in their Manchester-based laboratories, Apollo Scientific offers a selection of over 100,000 chemical products, from fluorinated compounds to non-fluorinated building blocks, for research and industry applications. Their life science products include antibiotics and buffers, as well as customized products for stem cell, molecular biology, and proteomics research. Additionally, Apollo Scientific offers spectroscopy products, such as consumables for infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry standards.
Avantor was founded in 1904 and is headquartered in Radnor, Pennsylvania, as a supplier of lab and production services such as general and technical lab services, production, and business process consulting services. The company offers various clinical services, including customized kitting solutions, clinical trial equipment, and ancillary services. The organization is regarded as a dependable global partner for customers and suppliers in the life sciences, advanced technologies, and applied materials industries, spanning from initial discovery to final delivery.
BLDpharm was founded in 2014 and headquartered in Shanghai, China is a manufacturer and supplier of various research chemicals. The company offers a wide range of laboratory chemicals including heterocycles, boron acids, amino acids, metal catalysts, and chiral compounds. These quality products find an array of applications as inhibitors for metabolic enzymes, pharmaceutical intermediates for antipsychotic drugs, catalysts for chiral resolving reagents, and material science for OLED material and synthesis intermediates.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Hunan Huateng Pharmaceutical Co. Ltd., established in 2013 and based in Changsha, China, is a supplier of PEG derivatives and a contract manufacturer of APIs and intermediates. It stocks chemical reagents, vaccine excipients, APIs, and pharmaceutical intermediates, among other chemicals. In 2016, the company launched the first R&D center in Changsha, and in 2020, it completed the construction of its company, which started operations. It is ISO 9001 certified and has a range of facilities to manufacture and store chemical products up to 10 Metric Tons.
SynThink Research Chemicals, based in Pune, India, is a supplier of pharmaceutical research products to pharmaceutical and biotech companies as well as R&D labs at various research institutes and organizations. The company provides pharmaceutical reference standards, API impurities, metabolites, intermediates, building blocks and other research chemicals. It also provides custom synthesis services and contract research and development (CRO) services in the area of organic, pharmaceutical, and medicinal chemistry. The company offers custom packaging and worldwide shipping of in-stock products within 24 hours.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | City Chemical LLC. |
16.7%
|
| 2 | Gelest Inc. |
16.7%
|
| 3 | Pharmaffiliates |
16.7%
|
| 4 | Alfa Chemistry |
11.1%
|
| 5 | Merck |
11.1%
|
| 6 | BLDpharm |
5.6%
|
| 7 | Apollo Scientific Ltd |
5.6%
|
| 8 | Biosynth |
5.6%
|
| 9 | Tokyo Chemical Industry Co., Ltd. |
5.6%
|
| 10 | MilliporeSigma |
5.6%
|
Derivation Method
The ranking is calculated based on the click share within the trimethylsilane page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
2 | 22.2% |
|
India
|
2 | 22.2% |
|
Switzerland
|
1 | 11.1% |
|
Japan
|
1 | 11.1% |
| United States | 1 | 11.1% |
|
United Kingdom
|
1 | 11.1% |
|
China
|
1 | 11.1% |
