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This section provides an overview for thiazoles as well as their applications and principles. Also, please take a look at the list of 7 thiazole manufacturers and their company rankings. Here are the top-ranked thiazole companies as of December, 2024: 1.KANTO CHEMICAL CO.,INC..
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Thiazole is a colorless to pale-yellow, transparent liquid at room temperature.
It is a heterocyclic aromatic compound with molecular formula C3H3NS and a molecular weight of 85.13. It has a characteristic unpleasant odor similar to pyridine. It is named by adding the prefix thia (thia-), meaning sulfur (S) in the ring, before azole, the name of a five-membered ring compound containing nitrogen (N). Heterocyclic aromatic compounds with S and N in the five-membered ring have two isomers: compounds with S and N adjacent (isothiazole: 1,2-thiazole) and compounds with S and N separated by one carbon (C) (thiazole: 1,3-thiazole).
It is found as a substructure of vitamin B1 (thiamine), epothilone, and other natural products. Sulfathiazole, also known as sulfa drugs (a generic term for synthetic antibacterial and chemotherapeutic agents containing a sulfonamide moiety), also contains a thiazole ring. Other thiazole azo dyes also contain a thiazole ring.
The main use of thiazole is as a raw material for organic synthesis.
In the thiazole ring, the 2-position reacts as a nucleophilic site and the 5-position as an electrophilic site. When a Grignard reagent or alkyl lithium is applied to thiazole, the hydrogen at the 2-position is removed and the thiazole is metalized. Also, when a nucleophile such as an amine is applied to 2-chlorothiazole, a substitution reaction occurs.
Many important derivatives of thiazole are used in industrial chemicals (vulcanization accelerators), fungicides, anthelmintics, pharmaceuticals, and dyes. Vulcanization is the bonding of rubber molecules together by sulfur to give the raw rubber high elasticity and usually requires a long time. Therefore, vulcanization accelerators are added. Thiazole-based vulcanization accelerators do not contaminate rubber and are suitable for transparent and colored products. They are also used in a variety of diene rubbers.
Regarding the use of thiazole as a disinfectant, since thiazole acts pharmacologically on microorganisms, it acts only when it is in direct contact with and absorbed by them. As a result, thiazole is used as an antiseptic in cosmetics, as a pesticide, and as a detergent in products in liquid or emulsion form.
Medicines containing the thiazole structure are mainly the antibiotic cefviron, the anticancer drug bleomycin, and thiamine (vitamin B1). It forms stable complexes with inorganic acids and mercuric chloride (II) and is therefore sold in various forms.
It is a type of amine of heterocyclic aromatic compounds, but it is less basic than pyridine and other compounds. It has a melting point of -27.4°F (-33 °C), a boiling point of 244.4°F (118 °C), a flash point of 78.8°F (26 °C), a specific gravity of 1.2 g/mL (at 25 °C), a refractive index n20/D 1.538, and is liquid at room temperature. It is soluble in many organic solvents, such as ethanol and ether, and slightly soluble in water.
Thiazole is obtained by condensation of chloroacetaldehyde (ClCH2CHO) with thioformamide (HCSNH2).
It is also obtained by dehydrocyclization of N-(2-mercaptoethyl) amide with thionyl chloride and oxidation with DDQ. The thiazole ring found in natural products is thought to be formed by a similar transformation of cysteine-containing peptides in many cases.
Precautions for handling and storage are as follows:
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | KANTO CHEMICAL CO.,INC. |
100.0%
|
Derivation Method
The ranking is calculated based on the click share within the thiazole page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
1 | 25.0% |
|
Japan
|
1 | 25.0% |
|
Canada
|
1 | 25.0% |
France
|
1 | 25.0% |
