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This section provides an overview for diacetyl as well as their applications and principles. Also, please take a look at the list of 10 diacetyl manufacturers and their company rankings. Here are the top-ranked diacetyl companies as of December, 2024: 1.Alfa Aesar, Thermo Fisher Scientific., 2.MedChemExpress, 3.KANTO CHEMICAL CO.,INC..
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Diacetyl is a yellow-green liquid known for its strong, characteristic odor. Its chemical formula is C4H6O2, with a molecular weight of 86.09, and its CAS number is 431-03-8. It comprises two acetyl groups linked to a carbonyl group's carbon. The IUPAC name for diacetyl is 2,3-butanedione.
Present naturally in alcoholic beverages, diacetyl is also added to various foods as a flavoring agent, imparting a buttery flavor due to its butter-like aroma when diluted.
Diacetyl finds extensive use in the food industry, particularly as a flavoring agent in margarine, butter and cheese-flavored snack foods, wine, and vinegar. It's also employed as a liquid flavoring in e-cigarettes. During the brewing process of beer and other alcoholic beverages, diacetyl is naturally produced by microorganisms. The brewing process is controlled to manage diacetyl levels, as excessive amounts can negatively impact the beverage's aroma.
Diacetyl boasts a melting point of -2°C, a boiling point of 88°C, and a density of 0.99 g/mL. It is flammable, with a flash point of 6°C and a spontaneous combustion point of 365°C. Its explosive vapor-air mixtures and solubility in water (20 g/100 mL) make it notable, along with its miscibility in most organic solvents. Diacetyl is also a natural fermentation byproduct, formed through thiamine pyrophosphate-mediated condensation of pyruvate and acetyl CoA in some bacteria.
Diacetyl and other vicinal diketones are distinguished by the long carbon-carbon bond between the two carbonyl centers, measuring 1.54 Å compared to 1.45 Å in 1,3-butadiene. This bond elongation results from the repulsive forces between the polarized carbonyl carbon centers.
Diacetyl is primarily produced by dehydrogenating 2,3-butanediol, with acetoin serving as an intermediate. An alternative method involves hydrolyzing methyl ethyl ketone with sodium nitrite and hydrochloric acid.
Although not designated under specific environmental or poisonous substance control laws, diacetyl is classified as a flammable liquid, and a hazardous and noxious substance, requiring careful handling.
Handling and storage precautions include keeping the container tightly closed in a cool, dry, and well-ventilated area, away from heat and ignition sources. It's important to wear appropriate protective gear and to take special precautions due to the risk of irreversible obstructive pulmonary disease upon exposure.
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Ernesto Ventós S.A. is a company that was established in 1916 in Sant Just Desvern, Spain, specializing in distributing aroma compounds and essential oils to the fragrance and flavoring industries. Ventós is a company that has established solid commercial partnerships with significant raw material producers. As a result, they have become a distinguished agent or distributor of goods for these producers. The company has a wide range of over three thousand products, allowing them to offer efficient just-in-time service to their clients.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Alfa Aesar, Thermo Fisher Scientific. |
40.0%
|
| 2 | Merck |
30.0%
|
| 3 | MedChemExpress |
20.0%
|
| 4 | KANTO CHEMICAL CO.,INC. |
10.0%
|
Derivation Method
The ranking is calculated based on the click share within the diacetyl page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
5 | 62.5% |
|
United States of America
|
1 | 12.5% |
|
United Kingdom
|
1 | 12.5% |
|
Spain
|
1 | 12.5% |
