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This section provides an overview for acetoin as well as their applications and principles. Also, please take a look at the list of 12 acetoin manufacturers and their company rankings. Here are the top-ranked acetoin companies as of December, 2024: 1.KANTO CHEMICAL CO.,INC., 2.Santa Cruz Biotechnology, Inc., 3.Jiangxi Zhongding Biotechnology Co., Ltd..
Table of Contents
Acetoin is a chemical compound with the molecular formula C4H8O2.
Acetoin, also known as 3-hydroxy-2-butanone or acetylmethylcarbinol, is classified as an α-hydroxy ketone (acyloin) due to its adjacent carbonyl and hydroxy groups in the molecule.
Acetoin serves primarily as a flavoring agent, widely used in various food products for its distinctive aroma reminiscent of butter or yogurt. It is commonly added to confectionery, margarine, coffee, caramel, tobacco, and dairy products.
Naturally, acetoin is produced during the aging of cream for butter production, and it is also found as an aroma component in fermented foods, vegetables, and fruits.
At room temperature, acetoin is a colorless to light yellow liquid with a buttery odor. It has a molecular weight of 88.11, a melting point of 15°C, and a boiling point of 148°C. Acetoin is readily soluble in water, ethanol, propylene glycol, ether, and dichloromethane, but slightly soluble in hydrocarbon solvents.
Acetoin is available in various capacities for research purposes, typically sold in frozen or refrigerated form.
Industrial and commercial flavoring agents containing acetoin are available, with detailed product information provided by individual manufacturers.
Acetoin can be synthesized through various methods, including thiazolium salt-catalyzed benzoin condensation of acetaldehyde, acyloin condensation of acetic acid esters, microbial oxidation of 2,3-butanediol, and fermentation of sorbose.
At room temperature, acetoin undergoes a chemical reaction resulting in the formation of a hemiacetalated dimer. This dimer can be converted back to a monomer by heating above its melting point.
Acetoin is classified as a flammable liquid: Category 3 and should be handled with care, keeping it away from ignition sources. It is designated as a hazardous and flammable substance under industrial safety and health laws and regulations.
*Including some distributors, etc.
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Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Merck KGaA was founded in 1668 and is a manufacturer of medical products and devices based in Darmstadt, Germany. The company manufactures various products such as erbitux, bavencio, tepmetko, glucophage, and eutyhrox. These products are used for various purposes such as general medicine treatments, cardiovascular diseases, childhood growth hormone deficiency, multiple sclerosis treatments, and merkel cell carcinoma. The company has obtained various certifications such as ISO 9001:2015, ISO 14001:2015, ISO 45001:2018, and ISO 50001:2018.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
AGROCHEMICALS is a Washingtonville, New York-based manufacturer of natural flavoring and fragrance ingredients founded in 1994. The company specializes in producing esters, alcohols, pyrazines, ketones, and terpenes. These primarily supply clients in the food and beverage, pharmaceutical and cosmetic industries. The company offers research and development services from its state-of-the-art facility, which has received Safe Quality Food (SQF) certifications from the Global Food Safety Initiative over the last six consecutive years. AGROCHEMICALS serves customers across five continents, including client corporations like Givaudan and Firmenich.
KOEI CHEMICAL CO. LTD. established in 1917 and based in Tokyo, Japan, is a manufacturer and supplier specializing in the production of chemical products. The company's product portfolio includes ionic liquids, amines, formalin products, pyridines, and pyrazines. These chemicals are utilized in various sectors, including pharmaceuticals, agricultural chemicals, electronics, furniture manufacturing, and the paint and coatings industry. The company is ISO 9001 and ISO 14001 certified, and provides custom synthesis and technical support to its clients.
Scientific Laboratory Supplies Ltd, established in 1981 and based in Hessle, United Kingdom, is a distributor and supplier of laboratory equipment, chemicals, and consumables. The company specializes in providing a comprehensive range of scientific instruments, glassware, chemicals, and lab supplies to research, educational, and industrial laboratories. The company’s products cater to various scientific disciplines, including chemistry, biology, and physics. Its products are utilized in facilitating scientific research and experimentation. The company is ISO 9001:2015 certified, ensuring quality management standards in the distribution of laboratory supplies.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | KANTO CHEMICAL CO.,INC. |
16.7%
|
| 2 | Santa Cruz Biotechnology, Inc. |
14.3%
|
| 3 | Jiangxi Zhongding Biotechnology Co., Ltd. |
11.9%
|
| 4 | AUROCHEMICALS |
9.5%
|
| 5 | Toronto Research Chemicals |
9.5%
|
| 6 | Junsei Chemical Co.,Ltd. |
9.5%
|
| 7 | INOUE PERFUMERY MFG. CO.,LTD. |
7.1%
|
| 8 | Merck |
7.1%
|
| 9 | Scientific Laboratory Supplies Ltd |
4.8%
|
| 10 | Merck KGaA |
4.8%
|
Derivation Method
The ranking is calculated based on the click share within the acetoin page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
5 | 55.6% |
|
United States of America
|
1 | 11.1% |
|
Canada
|
1 | 11.1% |
|
Germany
|
1 | 11.1% |
China
|
1 | 11.1% |
