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This section provides an overview for cyclooctane as well as their applications and principles. Also, please take a look at the list of 11 cyclooctane manufacturers and their company rankings.
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Cyclooctane is an organic compound, a cycloalkane (alicyclic compound) with a saturated 8-membered ring structure.
Its molecular formula is C8H16 and its CAS number is 292-64-8. It has a molecular weight of 112.21, a melting point of 12-14°C, and a boiling point of 150°C. At room temperature, it is a clear colorless to brown liquid.
It has a camphor-like odor (however, its molecular structure is completely different from camphor, a component of camphor). It is soluble in ethanol and acetone, but hardly soluble in water. Its solubility in water is 7.90 mg/L. It has a density of 0.836 g/mL (20°C) and a flash point of 30°C.
Cyclooctane is mainly used as a solvent and reagent. It is also useful as a synthetic intermediate, for example, as an intermediate in the manufacture of plastics, fibers, adhesives, and coatings.
Academically, it is also a representative of saturated 8-membered ring compounds, and its stereoconformation has been extensively studied using computational chemistry techniques.
The chemistry of cyclooctane includes combustion reactions and free radical halogenation reactions, which are typical of saturated hydrocarbons. For example, cyclooctane can be aminated by using a peroxide, such as dicumyl peroxide and nitrobenzene.
Although stable under normal storage conditions, in storage it should be kept away from high temperatures, direct sunlight, heat, flames, sparks, and static electricity. Mixture with strong oxidizing agents is also strictly prohibited. Hazardous decomposition products include carbon monoxide and carbon dioxide.
Cyclooctane is sold primarily as a reagent product for research and development. The volume types include 25 mL, 500 mL, and others. It is a reagent that can be handled at room temperature. However, it has a low flash point and is a compound regulated by the Fire Service Law, so it must be handled in compliance with the law.
Cyclooctane d-16, in which all hydrogen atoms are replaced with deuterium, is also available as a reagent product. This substance is used as a heavy solvent for NMR analysis. It is expensive due to the large number of deuterium atoms and is used in special cases where other solvents cannot be used.
Cyclooctane can be synthesized by hydrogenating Cyclooctadiene to saturated hydrocarbons. Compounds such as the intermediate 1,5-cyclooctadiene are first synthesized by dimerization of butadiene using a nickel(0) complex such as bis(cyclooctadiene)nickel as a catalyst.
Cyclooctane is synthesized by hydrogenation of cyclooctadiene by catalytic reduction.
Cyclooctane is a cycloalkane with a very complex stereochemistry due to the presence of several stereoconfigurations with similar energies. The conformations include boat-chair, canned, bucket, boat-boat, twisted boat-chair, and twisted chair-chair. The most stable configuration is reported to be boat-ice.
Cyclooctane has a low flash point of 30°C and is a highly flammable liquid and vapor.
Fire prevention includes the use of explosion-proof electrical equipment, ventilation equipment, and lighting equipment, the use of spark-proof tools, and measures to prevent electrostatic discharge. In addition, protective equipment such as protective gloves, protective clothing, protective glasses, and protective masks must be worn when handling this substance.
If it adheres to the skin, it is necessary to remove all contaminated clothing immediately and wash the skin under running water. Also, if swallowed and enters the respiratory tract, it may be life-threatening and extremely dangerous.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Evonik Industries AG, founded in 2007 and headquartered in Essen, North Rhine-Westphalia, is a manufacturer and supplier of pharmaceutical, and medical device. The company offers an extensive product catalog, which includes active pharmaceutical ingredients, bioresorbable medical devices, cell culture ingredients, excipients for oral solid dosage forms, and formulation development services. These products serve various critical applications, ranging from providing oral drug delivery solutions to enhance the efficacy of active pharmaceutical ingredients (API), functional coatings for improved nutraceutical performance and preference, biodegradable polymers for implantable medical devices, to surface modification technology that enhances the functionality and safety of medical devices.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
MuseChem Chemicals is an American chemical supplier located in Fairfield, New Jersey. They offer a wide range of products, including inhibitors and agonists, active pharmaceutical ingredients (APIs), and specialty chemicals. Research chemicals such as chemical reagents, bioactive chemicals, catalysts, and ligands are also part of their product offerings. MuseChem provides various services, including custom synthesis research of organic compounds for the agrochemical, chemical, and pharmaceutical industries. They also offer peptide synthesis services, ranging from bulk API peptides production to complex peptide modifications. Moreover, MuseChem offers bioconjugation services to create functional biomolecules for biomarker imaging, protein biodistribution, and cellular event tracking.
Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
3 | 33.3% |
|
United States of America
|
2 | 22.2% |
|
India
|
2 | 22.2% |
|
Canada
|
1 | 11.1% |
|
Germany
|
1 | 11.1% |
