All Categories
History
This section provides an overview for quinazoline as well as their applications and principles. Also, please take a look at the list of 11 quinazoline manufacturers and their company rankings. Here are the top-ranked quinazoline companies as of December, 2024: 1.SimSon Pharma Limited, 2.Molekula Americas LLC, 3.American Elements.
Table of Contents
Quinazoline is an organic compound with the molecular formula C8H6N2, known for its role in organic synthesis and pharmaceutical applications. It is a colorless to pale yellow crystalline powder with a characteristic odor, soluble in ethanol and acetone but insoluble in water.
The CAS number of quinazoline is 253-82-7. It has a molecular weight of 130.15, a melting point of 120-122°F (49-50°C), a boiling point of 469.4°F (243°C), and a density of 1.351 g/cm3. Its flash point is 222.8°F (106°C), and it has an acid dissociation constant (pKa) of 3.51.
Quinazoline and its derivatives are primarily used in organic synthesis. In medicine, these compounds serve as anti-malarial agents, and treatments for brain tumors, and other cancers. Quinazoline rings are also integral to antihypertensive drugs like doxazosin. Additionally, quinazoline compounds find applications in electronics, particularly in organic light-emitting diode (OLED) materials for displays.
Quinazoline is prone to various addition reactions, particularly at the N3 position, and undergoes hydrolysis in acidic or alkaline solutions. The decomposition products include 2-aminobenzaldehyde, formic acid, and ammonia. Its benzene ring is more reactive to electrophilic substitution reactions compared to the pyrimidine ring.
Available mainly for research and development purposes, quinazoline is sold in small quantities like 1 g or 5 g, and is considered a relatively expensive reagent. It is commonly handled at room temperature. Derivatives of quinazoline available commercially include 4-chloroquinazoline and quinazoline-2-carboxylic acid hydrochloride, among others.
Quinazoline can be synthesized through various methods, including the Niementowski quinazoline synthesis, which involves the reaction of anthranilic acid with amino acids. Another efficient method includes the introduction and removal of a tosylhydrazide group to 4-chloroquinazoline.
Derivatives of quinazoline, such as tyrosine kinase inhibitors, are used in molecular targeted therapies. Examples include gefitinib, erlotinib, afatinib, and lapatinib, which are used for treating various cancers.
*Including some distributors, etc.
Sort by Features
Sort by Area
American Elements was founded in 1997 in California and currently has research and production facilities in Utah, Mexico, China, and the United Kingdom. AE manufactures and distributes advanced materials from a catalog of over 30,000 products for bulk industrial use as well as small scale laboratory use. AE also provides testing and analyses services including spectroscopy along with structural, thermal, and electrical analyses. AE holds sustainable development as a core corporate value and is committed to work to protect the health of the environment.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Apollo Scientific Ltd, a subsidiary of Japan’s Central Glass Europe Limited, is a research chemicals manufacturer and supplier founded in 1993 and headquartered in Bredbury, United Kingdom. Performing chemical syntheses in their Manchester-based laboratories, Apollo Scientific offers a selection of over 100,000 chemical products, from fluorinated compounds to non-fluorinated building blocks, for research and industry applications. Their life science products include antibiotics and buffers, as well as customized products for stem cell, molecular biology, and proteomics research. Additionally, Apollo Scientific offers spectroscopy products, such as consumables for infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry standards.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
BLDpharm was founded in 2014 and headquartered in Shanghai, China is a manufacturer and supplier of various research chemicals. The company offers a wide range of laboratory chemicals including heterocycles, boron acids, amino acids, metal catalysts, and chiral compounds. These quality products find an array of applications as inhibitors for metabolic enzymes, pharmaceutical intermediates for antipsychotic drugs, catalysts for chiral resolving reagents, and material science for OLED material and synthesis intermediates.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
SynThink Research Chemicals, based in Pune, India, is a supplier of pharmaceutical research products to pharmaceutical and biotech companies as well as R&D labs at various research institutes and organizations. The company provides pharmaceutical reference standards, API impurities, metabolites, intermediates, building blocks and other research chemicals. It also provides custom synthesis services and contract research and development (CRO) services in the area of organic, pharmaceutical, and medicinal chemistry. The company offers custom packaging and worldwide shipping of in-stock products within 24 hours.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | SimSon Pharma Limited |
33.3%
|
| 2 | Molekula Americas LLC |
33.3%
|
| 3 | American Elements |
33.3%
|
Derivation Method
The ranking is calculated based on the click share within the quinazoline page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
2 | 25.0% |
|
Japan
|
2 | 25.0% |
|
India
|
2 | 25.0% |
|
Canada
|
1 | 12.5% |
|
United Kingdom
|
1 | 12.5% |
