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This section provides an overview for oxalic acid dihydrate as well as their applications and principles. Also, please take a look at the list of 16 oxalic acid dihydrate manufacturers and their company rankings. Here are the top-ranked oxalic acid dihydrate companies as of December, 2024: 1.Spectrum Chemical Mfg. Corp., 2.Toronto Research Chemicals, 3.KANTO CHEMICAL CO.,INC..
Table of Contents
Oxalic acid dihydrate is an organic compound represented by C2H2O4-2H2O.
The CAS number is 6153-56-6. It has a molecular weight of 126.07 and a melting point of 104-106°C. It is a white crystal or crystalline powder at room temperature. The compound is soluble in water and ethanol and insoluble in diethyl ether.
Oxalic acid dihydrate is hygroscopic, and therefore, when left in moist air, it will assume the dihydrate state. Dihydrate also precipitates from aqueous solutions.
Oxalic acid dihydrate is mainly used in the chemical field as a reagent, metal surface treatment agent, reducing agent, and intermediate raw material for pharmaceuticals. Specific examples are the production of persistent sulfa drugs, cerium oxalate, amino acid preparations, and alpha-keto acids. Due to its reducing properties, it can also be used in reductive titrations.
The compound is also approved as a food additive. However, when used as a food additive, the oxalic acid must be removed from the final product. Examples include the manufacture of glucose syrup and the refining of vegetable oils.
Other uses include raw materials for dyes and bleaching agents, and it is widely used.
Oxalic acid dihydrate becomes anhydrous when placed in a desiccator containing diphosphorus pentoxide or heated to 100°C. It has two carboxyl groups. It is a divalent carboxylic acid with two carboxyl groups and acts as an ionized acid in an aqueous solution.
The acid dissociation constants pKa are 1.27 and 4.27. Because of its property as a reducing agent, it is used as a primary standard in redox titration in analytical chemistry.
Oxalic acid dihydrate is mainly available as a reagent for research and development and as an industrial chemical. R&D reagents are available in 25g, 100g, 500g, 2.5kg, etc., and are supplied in volumes that are easy to handle in the laboratory. These reagent products can be stored at room temperature.
As industrial chemicals, they are available in large capacities that are easy to handle in factories, such as 20 kg. Main applications include metal surface treatment agents and raw materials for pharmaceutical intermediates.
Oxalic acid is abundantly contained in plants, and is the origin of its naming. Industrially, it is produced by extracting wood chips after treating them with alkali.
Oxalic acid dihydrate is hygroscopic and becomes dihydrate when left in moist air. It also precipitates from aqueous solution in the dihydrate state.
Typical synthesis methods are as follows:
Oxalic acid has the property (deleterious) of strongly binding to calcium ions. When it enters the bloodstream of a living body, it is believed to form oxalates with calcium, reducing the amount of calcium available to the body and inhibiting the coagulation and coagulation action of blood. The substance is also thought to cause some stones if taken in excess.
Some vegetables, such as spinach and ginger, contain oxalic acid, but it is water soluble and can be reduced by boiling in cooking. In addition, when taken with calcium at the same time, oxalic acid combines with calcium in the intestines to form oxalates, which are less likely to be absorbed by the body.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
ALPHA CHEMICA, established in 1985, is an Indian manufacturer and supplier of laboratory reagents and fine chemicals, headquartered in Mumbai, Maharashtra. Their wide range of products includes high-performance liquid chromatography (HPLC), analytical reagent/guaranteed reagent (AR/GR), laboratory reagents (LRs), and fine chemicals, catering to life science and other specialty research. During the COVID-19 pandemic and its aftermath, ALPHA CHEMICA offered BactGO, a disinfectant solution with stabilized hydrogen peroxide using silver-based chemistry, and BaVi-X, a 75% alcohol-based hand sanitizer.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Mitsubishi Gas Chemical Trading, Inc. (MGCT) is a distributor of electronics manufacturing materials, chemicals, and engineering plastics established in Tokyo in 2018 as a subsidiary of Mitsubishi Gas Chemical Company, Inc. (MGCC). The company primarily stocks various electronics manufacturing materials such as conductive pastes and solder-resistant inks for smartphones or PCBs, basic chemicals like methanol and ammonia for creating synthetic resins or fibers, and engineering plastics, sheets and films for molding. These supply MGCT's buy-and-sell operations that serve client manufacturers in the food and beverage, petrochemical, pharmaceutical and consumer electronics industries.
Hemadri Chemicals is a manufacturer, supplier, and distributor of industrial chemicals in Mumbai, India where it was established in 2012. Their product list includes Zinc Oxide, and various acids such as Benzoic Acid, Monochloro Acetic Acid, Boric Acid, Citric Acid, and Oxalic Acid along with Mono Sodium Phosphate, Disodium Phosphate, Trisodium Phosphate, and some other rare and common chemicals like Sulphamic Acid, Sodium Acetate, Zinc Sulphate, Borax Decahydrate and Menthol Products. These chemicals, including others, have vast use in the paint, pharmaceutical, and various chemical industries.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
GNH India, based in Mumbai, India, is a distributor of pharmaceutical products. The company caters to the whole spectrum of pharmaceutical trade starting from wholesale, tender supplies, orphan drugs, name patient access, biologics and vaccines. It sources from over 60 countries offering over 2,03,000 product lines covering original brands and true generic. It also provides contract manufacturing services for generic medicines and validated cold chain shipment services. The company has certified quality management and has acquired several certifications including ISO 9001:2015 for risk management criteria and WHO GSDP for preserved quality of pharmaceutical products and good distributive practices.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Spectrum Chemical Mfg. Corp. |
17.1%
|
| 2 | Toronto Research Chemicals |
13.2%
|
| 3 | KANTO CHEMICAL CO.,INC. |
11.8%
|
| 4 | Merck |
9.2%
|
| 5 | Hemadri Chemicals |
7.9%
|
| 6 | Junsei Chemical Co.,Ltd. |
7.9%
|
| 7 | Kishida Chemical Co.,Ltd. |
6.6%
|
| 8 | Glentham Life Sciences Limited |
5.3%
|
| 9 | Mitsubishi Gas Chemical Trading, Inc. |
3.9%
|
| 10 | FUJIFILM Wako Pure Chemical Corporation |
3.9%
|
Derivation Method
The ranking is calculated based on the click share within the oxalic acid dihydrate page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
6 | 42.9% |
|
India
|
5 | 35.7% |
|
United States of America
|
1 | 7.1% |
|
Canada
|
1 | 7.1% |
|
United Kingdom
|
1 | 7.1% |
