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This section provides an overview for succinic anhydride as well as their applications and principles. Also, please take a look at the list of 42 succinic anhydride manufacturers and their company rankings. Here are the top-ranked succinic anhydride companies as of December, 2024: 1.Polysciences, Inc., 2.KANTO CHEMICAL CO.,INC., 3.LobaChemie Pct.Ltd..
Table of Contents
Succinic anhydride, with the chemical formula C4H4O3, is a cyclic dicarboxylic acid anhydride formed by dehydrating succinic acid. This compound is known for its reactivity, especially in hydrolysis to succinic acid and esterification with alcohols to produce succinic acid esters. It appears as a colorless or white crystalline solid, soluble in ethanol and acetone but insoluble in water, and is an irritant to the skin and eyes.
Succinic anhydride's versatility is evident in its wide range of applications:
It is a key ingredient in producing alkyd and unsaturated polyester resins, utilized in paints, adhesives, and biodegradable plastics, contributing to resource recycling and CO2 emission reduction.
As an esterifier and acylating agent, succinic anhydride is pivotal in synthesizing diverse chemical products, including pharmaceuticals, dyes, and pigments, and acts as a curing agent for epoxy resins and a sizing agent in paper manufacturing.
Succinic anhydride is a colorless crystal that hydrolyzes in air back to succinic acid. Insoluble in water but soluble in various organic solvents, it has a melting point of 118°C, emits a pungent odor, and is thermally labile, reverting to succinic acid upon contact with water or under heat.
The molecule features a five-membered ring, comprising two carbonyl groups and one ether group, making it reactive towards nucleophiles, such as alcohols and amines, to form esters and amides, influencing its applications significantly.
Commercially, succinic anhydride is produced via the melamine-succinic acid process, where melamine acts as a catalyst, or through the dehydration of succinic acid using dehydrating agents. These methods highlight the efficiency and versatility in the production of succinic anhydride.
*Including some distributors, etc.
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Cambridge Isotope Laboratories (CIL) established in 1981, is a global supplier of stable isotopes and labeled compounds, headquartered in the United States. The company provides of products for research, environmental analysis, and medical applications.Their comprehensive product offerings include isotopically labeled standards, biochemicals, and gases, catering to many industries and scientific communities, with partnerships worldwide. They specializes in the process of labeling biochemical and organic compounds with highly enriched, stable (nonradioactive) isotopes of carbon, hydrogen, nitrogen and oxygen.
ChemScence, LLC., established in 2006, is an American manufacturer based in Monmouth Junction, New Jersey, specializing in building blocks and fine research chemicals. The company offers approximately 45,000 building blocks and intermediates, as well as thin layer chromatography, screening libraries, bioactive small molecules, and isotope compounds. ChemScence also provides dye and biochemical assay reagents, peptides, and natural products like glycosides, and steroids. Catering to a diverse clientele including universities, research institutions, as well as pharmaceutical and biotechnology companies, ChemScence extends its services to include custom chemistry solutions. Furthermore, the company offers technical expertise in the domain of new drug development.
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Polysciences, Inc. is a manufacturer based in US Warrington, Pennsylvania and established in 1961, specializing in fine chemicals for applications in industrial, consumer, academic research, and biotechnology sectors. The company provides a wide array of products and customized solutions, as well as custom synthesis and contract manufacturing services for industries such as life sciences, bioprocessing, microparticles, medical devices, and electronic chemicals. They have recently launched a new bioprocessing brand called Kyfora Bio. With expertise in custom synthesis and contract manufacturing, they support their clients’ product manufacturing processes and expedite their time to market.
MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
BeanTown Chemical, an American company founded in 2013 and headquartered in Hudson, New Hampshire, is a manufacturer, distributor and supplier of specialty chemicals. The company's product portfolio includes analytical products, inorganic products, organic products, organometallic products, and rare-earth compounds. These products find applications in various industries, including the pharmaceutical industry, chemical industry, government institutions, academia, and research and development (R&D). The company also provides customer services, including a product catalog, custom synthesis, tailored solutions, and special packaging.
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Jinan Qinmu Fine Chemical Co., Ltd., established in 2008, is a Chinese manufacturer of chemical products, headquartered in Jinan, Shandong. The company offers organic and inorganic chemicals, including solvent chemicals, catalysts, and auxiliaries. Additionally, the company provides dye and pigment chemicals, pharmaceutical and synthetic intermediates, active pharmaceutical ingredients (APIs), and biochemical products. Customized intermediates are also available to meet the specific needs of original equipment manufacturers (OEMs). As an ISO 9001 and ISO 14001 certified company, Qinmu Fine Chemical Co., Ltd. serves a global customer base, including clients like Miwon Specialty Chemical Co., Ltd., Synthos S. A., and Gujarat Fluorochemicals Limited (GFL).
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Key Organics Ltd, founded in 1973 and headquartered in Cypress, USA, is a manufacturer of chemical products for the pharmaceutical, agrochemical and biotechnology industries. The company is an international CRO specializing in synthetic organic chemistry, providing chemistry and analytical services, as well as BIONET products for the global Life Science industries. Its BIONET portfolio consists of over 300,000 intermediates, fragments, biochemicals, and building blocks, available in ex-stock and in >95% purity with same day dispatch. The company offers bespoke chemistry solutions, from the custom synthesis of a single compound to multiple and long-term FTE projects.
Hairui Chemical, founded in China, is a manufacturer of organic compounds. The company's product portfolio includes fluorine compounds, boric acid series, amino acid series, non-natural amino acid series, and organic catalyst series. Its products are used for pharmaceutical ingredients (APIs), various chemical and petrochemical processes, and biotechnological research and product development. The company has ISO 9001: 2015 quality system certification and exports its products to the United States, Europe, and Japan.
Apollo Scientific Ltd, a subsidiary of Japan’s Central Glass Europe Limited, is a research chemicals manufacturer and supplier founded in 1993 and headquartered in Bredbury, United Kingdom. Performing chemical syntheses in their Manchester-based laboratories, Apollo Scientific offers a selection of over 100,000 chemical products, from fluorinated compounds to non-fluorinated building blocks, for research and industry applications. Their life science products include antibiotics and buffers, as well as customized products for stem cell, molecular biology, and proteomics research. Additionally, Apollo Scientific offers spectroscopy products, such as consumables for infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry standards.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
JINAN JINBANG CHEMICAL CO., LTD was launched in 2015. in Shandong Peninsula, and is a chemical manufacturer of pharmaceutical raw materials, pharmaceutical intermediates, and cosmetic raw materials that product research and development companies use to create new compounds. The company's product catalog includes Glycinamide hydrochloride Cas 1668-10-6, Ammonium thiosulfate Cas 7783-18-8, and 1,3-Dibutyl-2-thiourea Cas 109-46-6. Besides providing chemicals like catalysts, PVC plasticizers, and surfactants, it also offers storage and quality control services.
iChemical Wako Pure Chemical Corporation, established in 2008 and headquartered in Shanghai, China, is a manufacturer of industrial chemicals. Its product portfolio includes solvents, catalysts, reagents, and building blocks, along with offerings in pesticides, herbicides, food additives, and surfactants. The company provide services such as custom synthesis, scale-up, punch-out, and procurement outsourcing. The company operates seven offices and logistic hubs, and is connected to 15,000 laboratories and manufacturers, offering a wide portfolio of 380,000 research chemicals. Its products and services have been utilized to groundbreaking scientific discoveries for over 20,000 organizations worldwide.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
BLDpharm was founded in 2014 and headquartered in Shanghai, China is a manufacturer and supplier of various research chemicals. The company offers a wide range of laboratory chemicals including heterocycles, boron acids, amino acids, metal catalysts, and chiral compounds. These quality products find an array of applications as inhibitors for metabolic enzymes, pharmaceutical intermediates for antipsychotic drugs, catalysts for chiral resolving reagents, and material science for OLED material and synthesis intermediates.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Shandong Look Chemical Co., Ltd., headquartered in Jinan, Shandong Province, China, is a manufacturer and supplier a diverse range of chemicals. Its product catalog includes organic intermediates, flavor and fragrance components, APIs (Active Pharmaceutical Ingredients), additives, and inorganic chemicals. These chemicals find applications across various industries, including food, feed additives, cosmetics, dyes, and industrial chemicals. The company adheres to ISO 9001 and ISO 2000 standards in manufacturing and maintains GMP-compliant labs and workshops.
Hefei TNJ Chemical Industry Co., Ltd., founded in 2001, is a chemical manufacturer and supplier in Hefei, Anhui, China. The company has a diverse product portfolio comprising over 60 key products spanning the Chemicals, Food, Pharmaceutical, and Personal Care sectors. Notable products include sophthalic acid, polylysine, as well as chlorin, and potassium acetate. To ensure product quality, the company maintains a robust quality management system that aligns with ISO 9001:2015 standards.
Aolisen Chemical Company, established in 2008 and based in Hangzhou, China, is a manufacturer and supplier of chemical intermediates. The company's product range includes tert-Butyl isocyanate, 1-Chloroethyl chloroformate, 2-(Trifluoromethyl)benzaldehyde, 1-Bromooctadecane, Succinic anhydride, and Propargylamine. These products find applications in pharmaceuticals, agrochemicals, medical purposes, dyes, and daily necessities. It primarily serves the pharmaceutical and chemical industries. Its services include research & development, commercial production, shipping and payment, and a quote & return policy.
Alfa Chemical Co., Ltd., founded in 1973 and headquartered in Zhengzhou, India, is a manufacturer and supplier of organic chemicals for researching, development and manufacturing. The company provides scientific analytical chemicals, material science and life science chemicals, and catalysts from grams to kilograms. These chemicals include building blocks, reagents, pharmaceutical intermediates, dyes & indicators, produced by standards and analytical methods such as NMR, HPLC and MS. The company has a production facility, test laboratories and research centers, and provides packaging and delivery services.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Merck Millipore, founded in 1954 and headquartered in Darmstadt, Germany, is a manufacturer, distributor, and supplier of life science products and services. Their diverse range of products finds applications in research, development, and manufacturing of biotechnological and pharmaceutical drug therapies. Some of their offerings include filters for removing contaminants from liquids and gases, chromatography columns for separating and analyzing complex mixtures, reagents used in various laboratory assays, antibodies for detecting and quantifying specific molecules, and cell culture media for growing and maintaining cells in culture. Their products and services are utilized significantly in the advancement of life sciences and drug development.
Henan Bon Industrial Company Ltd which was started in 2009, is a distributor, and manufacturer of agrochemicals, catalysts and chemical auxiliary agents. The company is located in Zhengzhou High-tech Development Zone. In 2011, it expanded its product line and entered the Fine Chemical market. Under this wing, they supply noble metal catalysts. They also produce organic phosphine ligands and OLED intermediates. Additionally, they synthesize electronic chemical materials and general chemicals. The main clientele is within the production and life science fields.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
HAZMAT Resource, Inc., located in Irvine, California, USA, is a distributor of hazardous materials response equipment and materials. They specialize in personal protective equipment (PPE), testing devices, and technical reference materials for hazardous materials (hazmat) response. Their product range includes PPE such as suits, gloves, boots, and respirators to safeguard hazmat responders from dangerous substances. They offer various testing devices like meters, detectors, and kits for precise identification and measurement of hazardous materials. Additionally, the company provides technical reference materials like books, manuals, and software, equipping responders with essential knowledge on hazardous material properties and safe handling procedures.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Polysciences, Inc. |
22.7%
|
| 2 | KANTO CHEMICAL CO.,INC. |
13.6%
|
| 3 | LobaChemie Pct.Ltd. |
9.1%
|
| 4 | Tokyo Chemical Industry Co., Ltd. |
9.1%
|
| 5 | MilliporeSigma |
9.1%
|
| 6 | BEANTOWN CHEMICAL |
4.5%
|
| 7 | Key Organics Ltd |
4.5%
|
| 8 | Glentham Life Sciences Limited |
4.5%
|
| 9 | Molekula Americas LLC |
4.5%
|
| 10 | Spectrum Chemical Mfg. Corp. |
4.5%
|
Derivation Method
The ranking is calculated based on the click share within the succinic anhydride page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
11 | 31.4% |
|
China
|
8 | 22.9% |
|
Japan
|
5 | 14.3% |
|
India
|
4 | 11.4% |
|
United Kingdom
|
4 | 11.4% |
|
Canada
|
1 | 2.9% |
Spain
|
1 | 2.9% |
France
|
1 | 2.9% |
