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This section provides an overview for mandelic acids as well as their applications and principles. Also, please take a look at the list of 17 mandelic acid manufacturers and their company rankings. Here are the top-ranked mandelic acid companies as of December, 2024: 1.BASF, 2.KANTO CHEMICAL CO.,INC., 3.Cayman Chemical Company.
Table of Contents
Mandelic acid, also known as alpha-hydroxyphenylacetic acid, phenylglycolic acid, or apricot acid, is a hydroxycarboxylic acid. It is a colorless crystal with a plate-like shape and is soluble in water, ethanol, ether, and isopropanol. Its aqueous solution exhibits acidic properties.
Mandelic acid can be produced synthetically by the reaction of benzaldehyde with hydrogen cyanide, followed by hydrolysis. It has an asymmetric carbon atom and exists as both D- and L-isomers, commonly known in the racemic form. The L-isomer is obtained by optical resolution with brucine, and the D-isomer with l-menthol. Mandelic acid is also a urinary metabolite of styrene and serves as an exposure indicator for workers handling styrene-containing organic solvents. Its name derives from the German word "Mandel," meaning almond.
Mandelic acid and its derivatives are used as antibacterial agents in treating urinary tract infections. It also serves as an analytical reagent, such as in the determination of zirconium, and as a precursor in the dye industry. Furthermore, it is utilized as an optical resolution agent for amines and in chiral preparations for the pharmaceutical, agrochemical, and cosmetic industries. As an α-hydroxy acid, it is also employed in skin care for keratin treatment.
Mandelic acid is a colorless, plate-like crystal. It is naturally found in seeds, fruits, and bark of almonds and other trees. The compound contains both carboxyl and phenolic hydroxyl groups, exhibiting acid and phenolic properties. It is a chiral molecule, often produced industrially as a racemic mixture.
As a chiral intermediate, it is used in pharmaceuticals, agrochemicals, and cosmetics. Additionally, it is a urinary metabolite of both styrene and ethylbenzene. It is used as a health indicator for workers exposed to these compounds and related organic solvents.
Mandelic acid, an aromatic α-hydroxycarboxylic acid with the chemical formula C8H8O3, consists of a benzene ring, a hydroxyl group, and an aldehyde group. It has a chiral carbon atom at the α-position and exists as two optical isomers. The racemic mixture is known as para-mandelic acid, with specific isomers obtainable through optical resolution with brucine and l-menthol.
Naturally found in almond and apricot seeds, mandelic acid is also industrially produced through organic synthesis. Mandelonitrile is synthesized by reacting benzaldehyde with sodium cyanide and sodium hydrogen sulfite. Hydrolysis of mandelonitrile with concentrated hydrochloric acid yields mandelic acid and ammonium chloride. The separation of these compounds is typically achieved using organic solvent extraction.
Due to environmental and toxicity concerns associated with metal cyanides, alternative synthesis methods have been developed, such as using acetone cyanohydrin instead of hydrogen cyanide and oxidizing phenylglycine under an acid catalyst.
*Including some distributors, etc.
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Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Spectrum Laboratory Products, Inc., established in 1971 in New Brunswick, NJ, is a manufacturer and supplier of fine chemicals, laboratory supplies, APIs, and equipment that are ISO 9001:2015 certified. The company makes chemicals such as controlled substances, colorants, oils, flavors and fragrances, and bases. It also supplies capsule machines, glassware washers, ointment mills, compounding essentials, and syringes. Its New Jersey and California plants are FDA registered, while the China lab is ISO 17025 certified.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Longchang chemical Co., Ltd., is a chemical manufacturer company and was established in 1996, located in Changyi City, China. The company with a close cooperation with the School of Chemistry and Molecular Engineering of Peking University and Qilu University of Technology, is constantly developing new products, from the initial sodium silicate to the subsequent main products and by-products of petroleum resin series. In 2015, they opened a new laboratory, making a major breakthrough in flame retardant and plasticizer and light curing products. They have passed the ISO-9001 quality system certification in 2018 and passed the environmental impact assessment audit.
Honeywell, founded in 1906, in Wabash, Indiana is manufacturer of automotive parts, building technologies, and performance and safety materials for aerospace, The company's product portfolio includes electronic guidance systems, cockpit instrumentation, lighting, automotive parts, and primary propulsion and secondary power turbine engines. The company serves industries such as Oil and Gas, Aerospace and Defense, Automotive and Transportation, Construction, and Power Generation. Their headquartere is located in Carolina and they have global sales offices and distributions channels.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
BASF Corporation, established in 1986 as the North American affiliate of BASF SE, is a manufacturer of chemical products, headquarters in Florham Park, New Jersey. The company operates 11 divisions which specialize in six business segments, namely chemicals, materials (such as plastics and rubber), industrial solutions, surface technologies (including construction chemicals and coating solutions), nutrition (for human and animal), and agricultural solutions. BASF's products find extensive applications across diverse industries such as automotive and transportation, construction, consumer electronics, energy, and furniture. Additionally, the company serves the medical and pharmaceuticals, paints and coatings, power tools, pulp and paper, as well as textile industries.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
RX Chemicals was founded in Mumbai, India, in 2011. RX Chemicals sells chemical-based products for many sectors including automobile, agriculture, airline, detergents, drain cleaning products, electrical gear, floor care, fuel treatment, gasses, personal care, laundry chemicals, medicine, oil spill chemicals, and accessories, as well as tools. RX Chemicals also provides a range of services including chemical inspection, logistics, chemical usage supervision, as well as tank cleaning. The company sells to customers both in India and customers internationally.
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
HAZMAT Resource, Inc., located in Irvine, California, USA, is a distributor of hazardous materials response equipment and materials. They specialize in personal protective equipment (PPE), testing devices, and technical reference materials for hazardous materials (hazmat) response. Their product range includes PPE such as suits, gloves, boots, and respirators to safeguard hazmat responders from dangerous substances. They offer various testing devices like meters, detectors, and kits for precise identification and measurement of hazardous materials. Additionally, the company provides technical reference materials like books, manuals, and software, equipping responders with essential knowledge on hazardous material properties and safe handling procedures.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Cayman Chemical Company |
10.9%
|
| 2 | BASF |
10.9%
|
| 3 | KANTO CHEMICAL CO.,INC. |
10.9%
|
| 4 | Glytone |
7.8%
|
| 5 | HAZMAT Resource, Inc. |
7.0%
|
| 6 | MedChemExpress |
7.0%
|
| 7 | LONGCHANG CHEMICAL |
6.2%
|
| 8 | LobaChemie Pct.Ltd. |
5.4%
|
| 9 | Toronto Research Chemicals |
5.4%
|
| 10 | Spectrum Laboratory Products, Inc. |
4.7%
|
Derivation Method
The ranking is calculated based on the click share within the mandelic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
4 | 36.4% |
|
India
|
4 | 36.4% |
|
Japan
|
1 | 9.1% |
|
Canada
|
1 | 9.1% |
|
United Kingdom
|
1 | 9.1% |
