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This section provides an overview for polyvinylpyrrolidone as well as their applications and principles. Also, please take a look at the list of 12 polyvinylpyrrolidone manufacturers and their company rankings. Here are the top-ranked polyvinylpyrrolidone companies as of December, 2024: 1.NIPPON SHOKUBAI CO., LTD., 2.PhytoTech Labs, 3.MDPI.
Table of Contents
Polyvinylpyrrolidone (PVP), also known as povidone or poly(N-vinylpyrrolidone), is a nonionic, water-soluble polymer synthesized from N-vinyl-2-pyrrolidone. It finds extensive use across a spectrum of industrial products, everyday items, and food products due to its versatility and safety.
Thanks to its excellent solubility in water, high moisture absorption, film-forming capabilities, adhesion, and dispersibility, PVP is beneficial in various sectors. Its safety for human health and environmental compatibility further extend its use in pharmaceuticals and food additives.
PVP serves multiple roles in the pharmaceutical industry. It's a base for the antiseptic povidone-iodine, stabilizes suspensions and emulsions, acts as a binder in tablets and capsules, and is a component of ointment and cream bases. Additionally, it enhances the hemocompatibility of hollow fibers in artificial kidneys.
As a stabilizer, binder, and dispersant, PVP is integral to vitamin and mineral supplements. Polyvinylpolypyrrolidone (PVPP), a cross-linked variant, is utilized as a clarifying agent in beer and wine and reduces astringency in tea-based beverages. Unlike PVP, PVPP is insoluble in water.
PVP is a linear, hygroscopic, non-crystalline polymer with a slight specific odor or odorless characteristic, a density of 1.2 g/cm3, a glass transition temperature range of 150~180℃, and a decomposition temperature of around 400℃. It dissolves in water, alcohols, and most polar solvents but not in acetone, esters, ethers, and hydrocarbons. Its nonionic nature provides low electrical conductivity and excellent insulating properties.
Polyvinylpyrrolidone is produced from acetylene and formaldehyde through the following processes:
1. Synthesis of Gamma-Butyrolactone
After reacting acetylene and formaldehyde under pressure, 1,4-butanediol is obtained by catalytic reduction. When this is heated to 200°C under a copper catalyst, an intramolecular dehydration reaction occurs, yielding γ-butyrolactone.
C2H2 + HCHO → HOCH2CH2CH2CH2OH (1,4-butanediol) → C4H6O2 (γ-butyrolactone)
2. Synthesis of N-Vinyl-2-Pyrrolidone
N-vinyl-2-pyrrolidone is obtained by treating γ-butyrolactone with ammonia to form 2-pyrrolidone, which is then subjected to pressurized acetylene.
C4H6O2 + NH3 → C4H7NO (2-pyrrolidone)
C4H7NO + C2H2→ C6H9NO
Another way to synthesize N-vinyl-2-pyrrolidone from γ-butyrolactone is by reacting it with monoethanolamine. Here, N-hydroxyethylpyrrolidone is produced from γ-butyrolactone and monoethanolamine. This is then vapor-phase dehydrated to yield N-vinyl-2-pyrrolidone.
C4H6O2 + HOCH2CH2NH2 → C6H11O3 (N-hydroxyethylpyrrolidone)
C6H11O3 → C6H9NO + H2O
3. Polymerization of N-Vinyl-2-Pyrrolidone
Vinylpyrrolidone is obtained by polymerization of N-vinyl-2-pyrrolidone by heating in the presence of hydrogen peroxide.
*Including some distributors, etc.
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FUJIFILM Irvine Scientific, founded in 1970 and located in Santa Ana, California, is a manufacturer and supplier of cell culture reagents, media, and medical devices to scientists in the cell culture research market. The company provides its products to clinicians and researchers working in regenerative medicine and cell therapy, cytogenetics and assisted reproductive technology, and cell culture for the mass production of vaccines and biotherapeutics. It serves markets such as biopharmaceuticals, cell therapy, cytogenetics, immunotherapy, cell therapy, and reproductive health. The company owns and operates two cGMP production facilities in Japan and the United States.
Caisson Labs Inc. was established in 2000 in Smithfield, Utah, USA, as a manufacturer of animal cell culture and plant tissue culture reagents. The company offers various products, including 2,4-Dichlorophenoxyacetic Acid (2,4-D), S.O.C. Medium, Activated Charcoal, Adenine Hemisulfate Salt, and Bacteriological Agar, Type II, among others. The products have extensive applications in various industries, serving as an agricultural herbicide, supporting cell culture in research sectors, contributing to water purification and medical applications, and serving as an indispensable component for microbiological studies and diagnostics. The company caters to various industries such as pharmaceuticals, food, cosmetics, medical, research, and agriculture.
HAMPTON RESEARCH CORP. was established in 1991 in Aliso Viejo, California, USA, as a manufacturer of protein and atom crystallization research products and related biochemicals. The company's product list consists of Index HT, ethylene imine polymer, polyethylene glycol 200, CrystalCap, and quartz capillary, among others. The products guide sample concentration in crystallization screening, promote biotherapeutic crystallization, aid X-ray data collection, and assist in techniques like liquid-liquid diffusion and gel acupuncture crystallization. The company caters to various industries, including pharmaceuticals, healthcare, technology, and manufacturing.
PhytoTech Labs, founded in 1997, is a manufacturer and distributor of plant research and laboratory products. The company is located in Lenexa, Kansas, and runs a European Union distribution center. They mainly supply kits, reagents, and equipment to those who deal with plant biotechnology, tissue culture, and science. They also distribute to firms involved with molecular biology, plant pathology, and defense. Additionally, they custom-manufacture several media like a woody plant, seed testing, and orchid, for clients to aid in their production and research.
Geno Technology, Inc., established in 1994 and based in St. Louis, Missouri, US, is a biotechnology manufacturer of bioassays, protein assays, and molecular biology products for research applications. The company's products include DNA and RNA, proteomics, detergents, antibody production, protein modification, and other products. Its education products are used in schools, colleges, universities, and research institutions worldwide. The company has a division in India, G-Biosciences Pvt Ltd., and a network of distributors and marketing partners worldwide.
Agdia, Inc., founded in 1981 and located in Elkhart, Indiana, is an ISO 9001:2015-certified supplier of plant pathogen and GMO testing solutions. The company provides diagnostic testing kits for plant pathogen identification and health screening, including diagnostic assays for detecting plant pathogens in fruit, vegetable, ornamental, and field crops. It offers custom testing technologies to help clients make knowledgeable plant health care decisions. These include immunostrip, ImmunoPrint, Immunoblot, Immunofluorescence, and nucleic acid hybridization technologies. The company also operates a testing services lab that uses all of the above technologies to screen plants from around the world.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
bioWORLD is a manufacturer and supplier of a wide range of products for life science research. It is headquartered in Dublin,Ohio, and was established in 1993. The company's main products include molecular tools, molecular life sciences reagents, biologicals and pure proteins or enzymes, and lab supplies for bio-medical. Some of its popular products are lectins, glycomatrix, proteins and enzymes. bioWORLD also offers services such as custom training programs and needs assessment. Its products are used by several organizations, including hospitals, public health, commercial laboratories, biotechnology, and pharmaceutical.
Nippon Shokubai Co. LTD., established in 1941 and headquartered in Osaka, Japan, is a chemical manufacturer providing diverse chemical materials. Some of its products include detergents, curing agents, heat-resistant resins, adhesives, and coatings for metal, and the products are used in various industries, including life science, ICT, consumer products, environment remediation, and energy. In 1941, the company started the first commercial production of Phthalic Anhydride, which led to the development of the vinyl chloride industry. It commercialized Ethylene Oxide in 1959 using domestic technologies and began mass-producing superabsorbent polymers in 1985.
MDPI was founded in 1996 and is based in Basel, Switzerland. The company is a pioneer in scholarly, open-access publishing, featuring 417 peer-reviewed journals and 9 conference journals with over 115,000 academic contributors. The company’s journals fall into 10 subjects including biology, economics, medicine, physical sciences, and public health. The company’s pear review system is a dingle-blind assessment with at least two independent reviewers, followed by a final decision of acceptance or rejection by the editor-in-chief. Authors may appeal editorial decisions in case of rejection of articles.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | NIPPON SHOKUBAI CO., LTD. |
13.5%
|
| 2 | PhytoTech Labs |
12.4%
|
| 3 | MDPI |
12.4%
|
| 4 | FUJIFILM Irvine Scientific |
9.0%
|
| 5 | bioWORLD |
7.9%
|
| 6 | HAMPTON RESEARCH CORP. |
7.9%
|
| 7 | Merck |
7.9%
|
| 8 | Agdia, Inc. |
6.7%
|
| 9 | Caisson Labs Inc. |
5.6%
|
| 10 | Geno Technology Inc. |
5.6%
|
Derivation Method
The ranking is calculated based on the click share within the polyvinylpyrrolidone page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
7 | 87.5% |
|
Switzerland
|
1 | 12.5% |
