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This section provides an overview for phenylhydrazine as well as their applications and principles. Also, please take a look at the list of 8 phenylhydrazine manufacturers and their company rankings.
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Phenylhydrazine is an organic compound classified as a hydrazine derivative.
Its chemical formula is C6H8N2, and one of the hydrogen atoms in the benzene ring is substituted with hydrazine (-NH-NH2).
Its molecular weight is 108.14, the melting point is 19.5℃, and the boiling point is 243.5℃ (decomposition). At room temperature, it is a colorless to yellow oily liquid or crystal, but turns dark red when exposed to air and light. Its density is 1.0978 g/cm3. The substance is slightly soluble in ethanol and acetone and insoluble in water.
Exposure to humans may cause contact dermatitis and acute hemolytic anemia, and adverse effects on the liver and kidneys have been reported. It should be handled with care.
Phenylhydrazine is mainly used as a synthetic intermediate for dyes, pharmaceuticals, agricultural chemicals, etc., as a reagent for the detection of sugars, aldehydes, and ketones, and for metal precipitation analysis.
In synthetic applications, it is often used as a synthetic intermediate, especially for indoles.
Phenylhydrazine is known to turn reddish brown when exposed to air or light. It is also a substance that forms 1/2 hydrates.
It is known to react with oxidants, especially lead dioxide. In storage, it is necessary to avoid mixing with these substances. In addition, carbon monoxide, carbon dioxide, and nitrogen oxides are produced during combustion.
Phenylhydrazine is sold primarily as a reagent for research and development. It is available as a stand-alone product as well as in hydrochloride salt and other products.
Phenylhydrazine reagent products include 5g, 5g, 100g, 500g, 25mL, 100mL, 500mL and other volumes that are easy to handle in the laboratory. These reagent products can be stored at room temperature. It is available in glass containers, etc.
Phenylhydrazine hydrochloride is also available in 5g , 100g , 500g and other capacities, and is supplied in polyethylene bottles. This is sometimes handled as a reagent that requires refrigerated storage.
The synthesis of phenylhydrazine is a two-step reaction. First, aniline is oxidized with sodium nitrite in the presence of hydrochloric acid. Phenylhydrazine can be produced by reducing the diazonium salt formed by this reaction.
In this case, sodium hydroxide and sodium sulfite are used for the reduction reaction. Tin (II) chloride can also be used as a reducing agent.
Phenylhydrazine reacts with aldehydes and ketones to form phenylhydrazone and with α-ketol to form osazone. Therefore, this substance is sometimes used as a reagent for the detection of these substances.
In terms of synthetic chemistry, it is used as a synthetic raw material for heterocyclic compounds such as pyrazole and pyridazine, and is also a synthetic intermediate for various indoles. Fischer indole synthesis is one of the most famous reactions.
Phenylhydrazine is a toxic substance known to cause contact dermatitis, acute hemolytic anemia, and adverse effects on the liver and kidneys. It is also known to cause carcinogenesis and hereditary diseases.
Since there have been cases of poisoning and other industrial accidents in the past, it is a substance that must be handled safely and in compliance with laws and regulations.
*Including some distributors, etc.
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Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
Ennore India Chemicals, established in 1995, and based in Tamil Nadu, India, is a manufacturer and supplier of industrial chemicals and cleaning solutions. The company serves various industries, including wastewater treatment, marine, power generation, and oil and gas. Ennore India Chemicals also provides fuel additives, corrosion inhibitors, descaling chemicals, chemicals for boiler water treatment, as well as chemicals for cooling towers. Their ISO 9001:2015 certification guarantees quality goods and environmentally friendly practices.
TLC Pharmaceutical Standards Ltd. is a manufacturer and supplier of reference standards for the pharmaceutical sector. It is headquartered in Mississauga, Ontario, Canada, and was established in 2006. The company specializes in the custom synthesis of complex organic compounds for use as reference standards by the bio-medical and pharmaceutical industries. It offers a wide range of reference standards, including active pharmaceutical ingredients (APIs), drug impurities, and metabolite standards. TLC Pharmaceutical Standards also offers services, such as custom synthesis and Analytical Services such as NMR Analysis and Mass Spectrometry Analysis. The company's customers include pharmaceutical companies, research institutions, and government agencies.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
RX Chemicals was founded in Mumbai, India, in 2011. RX Chemicals sells chemical-based products for many sectors including automobile, agriculture, airline, medicine, and accessories. Automobile products include carwash shampoo, compressor cleaner, and interior cleaners. Agricultural products include fungicides, herbicides, and pesticides. Airline products include exterior products such as deicing fluid, as well as interior products such as solvent cleaner. The company also provides a range of services including chemical inspection, logistics, chemical usage supervision, as well as tank cleaning.
Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
3 | 37.5% |
|
United States of America
|
2 | 25.0% |
|
Canada
|
2 | 25.0% |
|
Japan
|
1 | 12.5% |
