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This section provides an overview for pinacol as well as their applications and principles. Also, please take a look at the list of 11 pinacol manufacturers and their company rankings. Here are the top-ranked pinacol companies as of December, 2024: 1.Spectrum Chemical Mfg. Corp., 2.KANTO CHEMICAL CO.,INC..
Table of Contents
Pinacol is a divalent of alcohol and an important compound in organic chemistry.
Pinacol itself is sometimes used as an important intermediate in organic synthesis, and it is also the origin of the name of the pinacol rearrangement reaction. This rearrangement reaction proceeds under acid catalysis and converts an alcohol group to a ketone or aldehyde.
Pinacol is an important compound in organic synthesis and has a variety of uses.
Pinacol is used as a synthetic intermediate for many organic compounds. In particular, the pinacol rearrangement reaction, in which pinacol is converted to ketones under an acid catalyst, is widely used in organic synthesis.
The reaction of pinacol with aldehydes or ketones yields pinacol boronate esters, which can be used to protect the carbonyl group. Later, deprotection reactions under appropriate conditions regenerate the original aldehyde or ketone, which is useful for selective conversion of other moieties.
Pinacol has a reducing ability and is particularly suitable for the reduction of alkyl halides, aldehydes, and ketones.
Chiral ligands, such as pinacol acetate, are synthesized with pinacol and play an important role in catalytic asymmetric synthesis.
Pinacol (pinacol) has the chemical formula C6H14O2 and the IUPAC name is 2,3-dimethylbutane-2,3-diol.
It is a colorless crystalline or powdery solid with a distinctive sweet odor. Its melting point is 41-43°C and the boiling point is 171-172°C. It is somewhat soluble in water, but dissolves well in organic solvents such as ethanol and ether.
It is relatively stable against heat and light. However, it reacts with oxidants and strong acids, generating heat. It is recommended to store pinacol in closed containers in a cool and dry place.
Pinacol reacts with acids and bases to form a variety of compounds. For example, the pinacol rearrangement reaction, in which hydrolysis proceeds under acid catalysis to form ketones, is known. Pinacol plays an important role in synthetic organic chemistry and is used as a synthetic intermediate and protective group in the synthesis and conversion of a wide variety of compounds.
Pinacol is a type of bisecanediol in which two hydroxyl groups are bonded to adjacent carbon atoms. In the structure of Pinacol, the central four carbon atoms are arranged in a straight line, with a hydroxyl group attached to each of the two inner carbon atoms.
In its conformation, pinacol has two isomers (cis and trans). Both isomers are easily converted to each other by temperature and solvents, so cis-trans isomers are usually mixed.
This structure is the reason why pinacol exhibits unique chemical reactions. The pinacol rearrangement reaction is a typical example, in which adjacent hydroxyl groups react to form ketones, allowing the synthesis of a variety of ketones and the introduction of functional groups.
Pinacol is mainly produced by pinacol reduction, which is the reductive conversion of aldehydes and ketones to diols. Pinacol reduction is generally performed using metallic sodium or magnesium.
Aldehydes or ketones are dissolved in an appropriate solvent, such as ether or tetrahydrofuran. The aldehyde or ketone is then reduced using metallic sodium or magnesium. The metal is typically used in excess amounts.
During the reaction process, the sodium or magnesium is oxidized and the aldehyde or ketone is reduced to a divalent alcohol (pinacol). Once the reaction is complete, the reactants are cooled and the products are separated and purified by filtration or extraction.
Pinacol reduction is one of the reduction methods used in organic synthesis in many cases, allowing the efficient synthesis of divalent alcohols from aldehydes and ketones. However, this method requires caution because stereochemical control can be difficult and the products may react further in the presence of impurities.
*Including some distributors, etc.
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AOBChem, a company founded in 2009 and based in Los Angeles, California, is a manufacturer and supplier of building blocks and pharmaceutical intermediates. The company offers products such as benzod 1,3 dioxole-4,5-diol, 5-methoxymethoxy benzod 1,3 dioxol-4-ol, 4-trimethylsilyl phenyl methanol, and methyl 4-bromo-2,6-diethylbenzoate. Chemical intermediates like those offered by AOBChem play a critical role in the development of new products, from pharmaceuticals to specialty chemicals, and in advancing scientific knowledge through research. These products are used in industries such as pharmaceuticals, agrochemicals, specialty chemicals, material science, and research and development.
Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Apollo Scientific Ltd, a subsidiary of Japan’s Central Glass Europe Limited, is a research chemicals manufacturer and supplier founded in 1993 and headquartered in Bredbury, United Kingdom. Performing chemical syntheses in their Manchester-based laboratories, Apollo Scientific offers a selection of over 100,000 chemical products, from fluorinated compounds to non-fluorinated building blocks, for research and industry applications. Their life science products include antibiotics and buffers, as well as customized products for stem cell, molecular biology, and proteomics research. Additionally, Apollo Scientific offers spectroscopy products, such as consumables for infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy, as well as mass spectrometry standards.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Allychem Co., Ltd., established in 2004 in Jinzhou New District, Dalian, China, is a manufacturer specializing in organoboronic acids and derivatives. The company's extensive product portfolio includes Potassium Trifluoroborate and Tetrafluoroborate Salts, Arylboronic Acids and Derivatives, Heterocyclic Boronic Acids and Derivatives, Alkylboronic Acids and Derivatives, as well as chiral compounds. These organic chemicals serve various purposes, such as the rectification method used to reduce the water content of industrial methanol to below 0.01%, scientific research involving aryl-containing fine chemicals like medicines and pesticides, and biological applications for transmembrane transport, bio marking, and protein labeling.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Boron Molecular is a manufacturer and supplier of specialty chemicals such as agents, energy storage compounds, monomers and polymers. It was established in 2001 and is headquartered in Noble Park, Victoria, Australia. The company produces a wide range of specialty chemicals, including boron compounds, boronic acids, and organic building blocks. Its products, such as B2O3, H3BO3, tetrakis(hydroxymethyl) borate, 1,2-dihydroxy borate, and Yb3+-doped YAG laser crystal, are used by a number of industries, as diverse as pharmaceutical, chemical, and materials industries. Boron Molecular also provides a range of services, including custom synthesis, formulation, packaging, and logistics.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Spectrum Chemical Mfg. Corp. |
50.0%
|
| 2 | KANTO CHEMICAL CO.,INC. |
50.0%
|
Derivation Method
The ranking is calculated based on the click share within the pinacol page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
3 | 37.5% |
|
Japan
|
2 | 25.0% |
|
United Kingdom
|
1 | 12.5% |
|
Switzerland
|
1 | 12.5% |
|
China
|
1 | 12.5% |
