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This section provides an overview for pantethine as well as their applications and principles. Also, please take a look at the list of 10 pantethine manufacturers and their company rankings. Here are the top-ranked pantethine companies as of December, 2024: 1.Wuxi Cima Science Co.,Ltd, 2.AVANSCURE LIFESCIENCES PVT. LTD, 3.Manus Aktteva Biopharma LLP.
Table of Contents
Pantethine is an organic compound, recognized as a dimer of pantetheine, connected through disulfide bonds. It serves a pivotal role in human physiology, similar to pantothenic acid (vitamin B5), from which it is derived.
The molecular formula for pantethine is C22H42N4O8S2. Pantetheine, pantethine's monomer, is an amide formed from pantothenic acid and cysteamine (2-mercaptoethylamine), showcasing similar biological activities to pantothenic acid. Pantethine's CAS registration number is 137-08-6, highlighting its significance in scientific and health-related fields.
Pantethine mirrors the biological activities of pantothenic acid, making it a valuable component in nutritionally functional foods and medicinal products designed to prevent or treat pantothenic acid deficiency. Furthermore, it finds applications in cosmetics, acting as a key ingredient in hair and skin conditioning agents.
Pantothenic acid, or vitamin B5, is an essential nutrient involved in the metabolism of carbohydrates, fats, and proteins. It also promotes healthy intestinal motility and skin maintenance. Although dietary deficiencies are uncommon, supplementation with Pantethine can be beneficial in situations where the demand for pantothenic acid increases, such as during illness, pregnancy, or hyperthyroidism, as well as in managing conditions like hyperlipidemia, atonic constipation, and dermatological issues.
Pantethine has a molecular weight of 554.72 and boasts a boiling point of 987.2°C. It appears as a colorless to slightly yellow, clear viscous liquid at room temperature. Pantethine is soluble in water, methanol, and ethanol, though it degrades upon exposure to light. Its density is 1.28 g/mL.
Pantethine is marketed for various uses, including in research, pharmaceuticals, and industry.
As a reagent for R&D, pantethine is available as D-pantethine. These products come in quantities ranging from 50mg to 5g and require refrigeration or freezing for proper storage.
In pharmaceutical formulations, pantethine is utilized to prevent and treat pantothenic acid deficiencies. Available in forms such as tablets, powders, and injections, these products vary by manufacturer.
Industrially, pantethine is sold in bulk, with quantities like 1kg and 25kg, for use as a synthetic material or intermediate in pharmaceuticals and other chemical productions.
Pantothenic acid, also known as vitamin B5, is a component of coenzyme A (CoA) and plays a critical role in carbohydrate and fatty acid metabolism. Pantetheine results from the condensation of pantothenic acid with cysteamine, forming an amide bond. Pantethine is then created through the oxidation and disulfide bonding of two pantetheine molecules.
These compounds are essentially identical in physiological function, acting in concert with CoA and 4'-phosphopantetheine as cofactors in vital metabolic processes.
Coenzyme A is a vital coenzyme composed of pantothenic acid, adenosine diphosphate, and cysteamine. Its thiol group, derived from cysteamine, is capable of forming thioester bonds with various acyl groups, facilitating key metabolic reactions like the citric acid cycle and β-oxidation. CoA and its derivatives, such as acetyl-CoA, are central to numerous metabolic pathways, underscoring their importance in biological systems.
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
NutraCap Labs was founded in 2016 and headquartered in Atlanta, Georgia, as a manufacturer and distributor of wellness and fitness supplements. The company specialises in manufacturing Nutraceuticals/Dietary Supplements which consist of encapsulation manufacturing, sports nutrition, raw health powders and product formulations. The company offers clients contract Manufacturing, custom formulation, private labelling, brand design and distribution to help them build their brand. NutraCap Labs is a fully certified GMP compliant and FDA registered company that has a sister company, Active Wholesale USA, through which they market and sell supplements to retail stores worldwide.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Avanscure Lifesciences Private Limited, established in 2012 and based in Gurugram, Haryana, India is a manufacturer of active pharmaceutical ingredients. The company manufactures pharmaceutical nutraceuticals, vitamins, food additives, amino acids, and anti-cancer drugs. It is located in the industrial areas of Gurugram and doubles up as a supplier and trader of industrial and laboratory chemicals. It caters to the health and wellness industry, with a special importance on oncology, hormones and peptides. The company has a modern chemical processing unit, where superior technology is used to process chemicals like Amiodarone, Hydrochloride, Acetazolamide, and Bethanechol chloride.
Hangzhou Keying Chemical Co., Ltd., founded in China, is a supplier of fine chemicals, polymers, food, and feed additives. The company's product portfolio includes a wide range of polymers, including plastics, resins, and specialty materials. These materials find applications in diverse industries, from manufacturing to packaging. It also offers food additives including preservatives, flavors, colorants, and nutritional components and feed additives for the agricultural and livestock sectors, improving the health and productivity of animals.
Shaanxi Rebeccia, founded in China, is a supplier of plant extracts, herbal active ingredient separation, and traditional Chinese herbal medicine functional compound research. The company's product portfolio includes standardized herb & plant extracts, active pharmaceutical ingredients, beta-nicotinamide mononucleotide (NMN), health products raw materials, and natural food & cosmetics ingredients. Its products are used in pharmaceuticals, dietary supplements, and natural cosmetics. The company has three production lines with over 100 plant extracts and an annual production capacity of over 500MTS.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Wuxi Cima Science Co.,Ltd |
30.8%
|
| 2 | AVANSCURE LIFESCIENCES PVT. LTD |
30.8%
|
| 3 | Manus Aktteva Biopharma LLP |
15.4%
|
| 4 | Hangzhou Keying Chemical Co., Ltd. |
7.7%
|
| 5 | Shaanxi Rebeccia |
7.7%
|
| 6 | Santa Cruz Biotechnology, Inc. |
7.7%
|
Derivation Method
The ranking is calculated based on the click share within the pantethine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
4 | 57.1% |
|
China
|
2 | 28.6% |
|
India
|
1 | 14.3% |
