All Categories
This section provides an overview for papaverine as well as their applications and principles. Also, please take a look at the list of 7 papaverine manufacturers and their company rankings. Here are the top-ranked papaverine companies as of December, 2024: 1.JOSHI AGROCHEM PHARMA PVT LTD, 2.Santa Cruz Biotechnology, Inc., 3.Alfa Aesar, Thermo Fisher Scientific..
Table of Contents
Papaverine is an opium alkaloid used in medicine.
Its IUPAC name is 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxyisoquinoline, also known as 6,7-dimethoxy-1-(3,4-dimethoxybenzyl)isoquinoline and Robaxapap.
Papaverine, present in opium at 0.8-1%, has a weaker central action and anesthetic effect compared to morphine. Its hydrochloride form relaxes visceral and vascular smooth muscles, alleviating abdominal pain by reducing tension in the gastrointestinal tract. It is effective for spasms related to gastritis, bile duct, and gallbladder diseases, and improves blood circulation by relaxing vascular smooth muscles, aiding in conditions like acute arterial and pulmonary embolisms, and circulation disorders.
With a chemical formula of C20H21NO4 and a molecular weight of 339.39, papaverine is a white crystalline solid. It has a melting point of 147°C, a density of 1.337 g/ml, and is registered under CAS number 58-74-2. Light and moisture sensitive, it is soluble in alcohol, ether, acetone, and benzene, with limited solubility in chloroform, petroleum ether, and water (35 mg/L at 17°C). Its pH range is 2.0 to 2.8, with a pKa of 8.07, indicating a relatively weak acid.
Papaverine hydrochloride (CAS Registration Number: 61-25-6) is a common form, a white crystal or powder with a molecular weight of 375.85, melting point of 220-225°C, soluble in alcohol and chloroform, and water solubility of 25mg/ml.
Papaverine is produced mainly through chemical synthesis, involving the Schotten-Baumann reaction for amide synthesis, followed by cyclization through the Bischler-Napieralski reaction, and mild dehydrogenation to synthesize papaverine.
Reported side effects include constipation, dizziness, hot flashes, dry mouth, and palpitations. It is considered safe with no serious side effects but should be used cautiously by glaucoma patients due to potential increases in intraocular pressure.
Papaverine is regulated under national dangerous goods shipping, storage regulations, and aviation law, classified as a poisonous substance.
Avoid contact with strong oxidizing agents. Use protective clothing, gloves, goggles, and a local exhaust system when handling. In case of fire, extinguish using appropriate means. Store in a tightly closed glass container away from light in a cool, well-ventilated area.
*Including some distributors, etc.
Sort by Features
Sort by Area
American Regent, Inc. was founded in 1967, and its headquarters is in Shirley, New York, United States, as a generic and branded speciality injectables manufacturer. American Regent, Inc. has established a status for being very responsive and dependable in its operations as a manufacturing company based in the United States, boasting a streamlined supply chain. Daily, the organization employs resourceful cognitive processes to effectively address its customers' demands by creating and distributing intricate injectable medications and products that are challenging to make.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
Joshi Agrochem Pharma, established in 1971 and based in Mumbai, India, is a manufacturer, supplier, and exporter of various chemicals, solvents, and metals. The company maintains a stock of agro fertilizers, pesticides, and pharmaceuticals. It has a readily available inventory of 2,000 products, including agrochemicals, solvents, and APIs. These products are utilized in a range of industries, such as automobile, aerospace, and agriculture. The company holds ISO 9001 and ISO 14001 certification and operates as part of the Joshi Group of companies, which is comprised of four companies that are segmented to ensure smooth business in varying domains.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | JOSHI AGROCHEM PHARMA PVT LTD |
33.3%
|
| 2 | Santa Cruz Biotechnology, Inc. |
33.3%
|
| 3 | Alfa Aesar, Thermo Fisher Scientific. |
11.1%
|
| 4 | MilliporeSigma |
11.1%
|
| 5 | nacalai |
11.1%
|
Derivation Method
The ranking is calculated based on the click share within the papaverine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
2 | 33.3% |
|
Japan
|
2 | 33.3% |
|
United Kingdom
|
1 | 16.7% |
|
India
|
1 | 16.7% |
