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This section provides an overview for toluene sulfonic acids as well as their applications and principles. Also, please take a look at the list of 15 toluene sulfonic acid manufacturers and their company rankings. Here are the top-ranked toluene sulfonic acid companies as of December, 2024: 1.Nova International, 2.D.K. Pharmachem Pvt.Ltd., 3.ANTARES CHEM PRIVATE LIMITED.
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Toluene sulfonic acid is an aromatic sulfonic acid with the chemical formula C7H8O3S.
Toluenesulfonic acid has a structure in which one hydrogen in the aromatic ring of toluene is replaced by a sulfonic acid. In principle, there are three isomers: o-toluene sulfonic acid, m-toluene sulfonic acid, and p-toluene sulfonic acid, but since toluene is o (ortho) and p (para) oriented, and the ortho form has significant steric hindrance, p-toluene sulfonic acid is generally referred to. p-toluenesulfonic acid.
In the following, unless otherwise noted, p-toluene sulfonic acid is used.
Tosic acid is commonly known as "tosyl acid," and its abbreviations include PTSA, TSA, and TsOH. Because of its tidal solubility and tendency to absorb moisture, toluene sulfonic acid is often sold commercially as monohydrate.
CAS registration numbers are 104-15-4 (anhydrous) and 6192-52-5 (monohydrate). It has a molecular weight of 172.20 and a melting point of 106-107℃ (anhydrous)/103-106℃ (monohydrate), and is a colorless or white solid at room temperature.
It is soluble in water, ethanol, and ether. Since it is tidally soluble and is altered by light, care should be taken when storing it to keep it away from sunlight and moisture.
Toluene sulfonic acid is widely used in the field of synthetic chemistry as a raw material for synthesis of pharmaceuticals, intermediates for agrochemicals, dyes, and paints, as a raw material for resin curing agents, and as a general purpose acid catalyst.
It also acts as a surfactant because it has both hydrophilic (sulfonic acid) and hydrophobic (toluene) groups. Used as a solubilizer in synthetic detergents, toluene sulfonic acid helps ingredients mix evenly and improves formulation stability.
Aqueous solutions of toluene sulfonic acid are highly acidic. p-toluene sulfonic acid has an acid dissociation constant pKa of -2.8. In organic synthesis, p-toluene sulfonic acid is widely used as an acid catalyst because it is a strong acid that is soluble in organic solvents and the anion of the conjugate base has a low nucleophilic property.
When phosphorus pentachloride is applied to the sodium salt of p-toluene sulfonic acid, paratoluene sulfonyl chloride is obtained. Nucleophilic substitution of the hydroxy group of an alcohol may be achieved by converting the hydroxy group to a paratoluenesulfonic acid ester (tosylate) and then applying a nucleophile to replace the tosyl group with the desired nucleophile.
This is because the paratoluenesulfonate anion is an excellent leaving group.
Toluene sulfonic acid is available in three types: o-toluene sulfonic acid, m-toluene sulfonic acid, and p-toluene sulfonic acid. o-toluene sulfonic acid and m-toluene sulfonic acid are only slightly distributed, with p-toluene sulfonic acid being the most common. Products include reagents for research and development and industrial chemicals.
The R&D reagent product is sold primarily as p-toluene sulfonic acid monohydrate. The capacities include 25 g, 100 g, 500 g, 1 kg, and 5 kg, and are offered in capacities that are easy to handle in the laboratory.
Industrial chemicals include monohydrate (solid), aqueous solutions (e.g. 70%), and methanol and ether solutions. Solid products are available in capacities of 20 kg (paper bags), 60 kg (drums), 200-230 kg (flexible container bags), etc. Liquid products are offered in tanker trucks, containers, chemical drums, etc. These products are offered in large capacities to meet the needs of factories and other facilities.
Toluene sulfonic acid is synthesized by sulfonation of toluene with concentrated sulfuric acid or fuming sulfuric acid. The main product is the para form, but the ortho form, a byproduct, is the raw material for saccharin. The main impurities are benzene sulfonic acid and sulfuric acid.
*Including some distributors, etc.
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Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Hefei TNJ Chemical Industry Co., Ltd, established in 2001, is headquartered in China. The company is a chemical manufacturer and supplier of chemicals to domestic Chinese and global consumers in four primary markets: chemicals, food, pharmaceuticals, and personal care. Chemicals include fine chemicals, agrochemicals, and other chemicals. Food includes agrochemicals, vitamins, amino acids, and food ingredients. Pharmaceuticals include specific chemicals such as Povidone iodine, Clotrimazole crystalline, and Lincomycin. The company also features a CAS databank for CAS-registered chemical compounds.
Sheetal Chemicals is an Indian manufacturer and supplier of industrial and specialty chemicals that was established in Mumbai, Maharashtra in 1997. The company produces various chemical products including industrial chemicals (e.g. solvents), active pharmaceutical ingredients (APIs), and specialty chemicals like catalysts and pesticides. It also offers imported chemicals such as hydroquinone and benzoyl chloride. Sheetal Chemicals chiefly serves clients in India’s agricultural and pharmaceutical sectors, as well as its pigments and dyes industry.
Nandadeep Chemicals Pvt. Ltd. was founded in 1997 in Mumbai, India, and is a manufacturer of specialty chemicals such as Aryl sulfonic acids and salts for the following industries: cosmetics, pharmaceuticals, foundry, and surfactants. Besides manufacturing and exporting Para toluene sulfonic acid, the company also supplies grades of Sodium cumene sulfonate, Xylene sulfonic acid, Sodium toluene sulfonate, and Phenol sulfonic acid solutions. The products are made in compliance with the ISO 9001:2015 standards.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
ECSA Group, founded in Switzerland, in 1913 is a manufacturer of chemical and petroleum products. The company's product portfolio includes f chemical products, including specialty chemicals, solvents, additives, and catalysts that support manufacturing, and refined products such as fuels, lubricants, greases, and waxes. The company serves industries such as Oil and Gas, Aerospace and Defense, Automotive and Transportation, Construction, and Power Generation. They operate in countries in Europe and has more than 15,000 active customers.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Techno Color Corporation, founded in 1992 and headquartered in Vapi, Gujarat, India, is a manufacturer, exporter, supplier, and distributor of specialized colorants and additives for the plastics and coatings industries. The company specializes in producing a wide range of pigments, dyes, and functional additives used in the coloring and enhancement of various plastic and coating materials. Its product line includes acid dyes, metal dyes, direct dyes, salt dyes, and solvent dyes. These products find applications in industries such as automotive, packaging, and consumer goods manufacturing.
HELM AG, founded in Hamburg, Germany, in 1900 is an international marketing company for chemicals. The company provides marketing services in Chemicals, Feedstocks and Derivatives, Crop Protection, Active Pharmaceutical Ingredients and Pharmaceuticals and Fertilizers. The company serves markets including Medical, Agriculture, Pharmaceutical and Biotechnology, Chemical and Petrochemical, and food and beverage. The company also provides services such as distribution, logistics, production and project development to scientific, training and technical services.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Nova International |
12.3%
|
| 2 | D.K. Pharmachem Pvt.Ltd. |
10.3%
|
| 3 | ANTARES CHEM PRIVATE LIMITED |
9.6%
|
| 4 | Sheetal Chemicals |
7.5%
|
| 5 | HELM AG |
7.5%
|
| 6 | TECHNO COLOR CORPORATION |
6.8%
|
| 7 | Weifang Shunfuyuan Chemical Co.,Ltd. |
6.2%
|
| 8 | ECSA Group |
5.5%
|
| 9 | Hefei TNJ Chemical Industry Co.,Ltd. |
5.5%
|
| 10 | Parchem |
5.5%
|
Derivation Method
The ranking is calculated based on the click share within the toluene sulfonic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
5 | 41.7% |
|
China
|
2 | 16.7% |
Taiwan
|
2 | 16.7% |
|
United States of America
|
1 | 8.3% |
|
Japan
|
1 | 8.3% |
|
Germany
|
1 | 8.3% |
4 products found
4 products
Meiyu Sangyo Co., Ltd.
30+ people viewing
■Features ・Soluble in water and many organic solvents. ・This product has a lower sulfuric acid content than our first product. ・It has the prope...
Meiyu Sangyo Co., Ltd.
30+ people viewing
Last viewed: 1 day ago
This product is a special product made into an aqueous solution (70% in terms of monohydrate).
