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This section provides an overview for trimethylamine as well as their applications and principles. Also, please take a look at the list of 16 trimethylamine manufacturers and their company rankings. Here are the top-ranked trimethylamine companies as of December, 2024: 1.Chemanol, 2.Jigs chemical, 3.Univar Solutions Inc..
Table of Contents
Trimethylamine is a type of methylamine in which three hydrogens of ammonia are replaced by methyl groups.
It is classified as a specific malodorous substance and is a gaseous organic compound at room temperature with a very strong fish odor. It is also known as N,N-dimethylmethylamine.
Trimethylamine is used in many things, but it is generally not used in a gaseous state, but rather in an aqueous solution of about 30~40% dissolved in water. It is highly soluble in water and miscible with water in any ratio.
Specifically, it is used as a raw material for ion exchange resins, choline chloride, fiber oil, reverse soap, and pharmaceuticals. In addition, as a familiar example, it is originally present in processed low-fat fish products such as surumeika, nishin, and bora, and in raw fish products such as suzuki, etc. In Europe and North America, it is often used as a food additive to add flavor and flavor to various foods such as confectionery, meat products, frozen dairy products, soft drinks, etc. It is also used as a food additive to improve flavor and aroma of various foods.
The structural formula of trimethylamine is (CH3)3N. As can be seen from the structural formula, all the hydrogen of ammonia (NH3) is replaced by methyl groups. It has a molecular weight of 59.11, a density of 0.67 g/ml (0°C), a melting point of -117.1°C, and a boiling point of 2.9°C. It is a colorless, transparent gas at room temperature.
It is an extremely flammable and combustible gas, and has been shown to be harmful by inhalation and adhesion. Trimethylamine is characterized by its strong fish odor, but because it is an alkaline substance, it is known that it can be made odorless by reacting with acidic substances, and acidic deodorants are generally used for amine-based odors.
It is regulated by the Malodor Control Law and is registered as a specified malodorous substance. Specified malodorous substances are substances that cause unpleasant odors and may damage the living environment. The fact that only 22 substances are currently designated shows the strength of their odor.
Trimethylamine is the most basic tertiary amine and is industrially produced by the reaction of methanol and ammonia in the presence of a dehydration catalyst.
1. Synthesis of Methylamine
First, a mixture of methanol and ammonia is passed through a dehydration catalyst such as alumina under pressure of 1.0~2.1 MPa at 450~500℃ to synthesize a mixture of three types of methylamines: monomethylamine, dimethylamine, and trimethylamine.
2. Separation of Trimethylamine by Dehydration and Distillation
After the product is distilled under pressure to separate the raw material methanol from the water produced, an azeotropic mixture of ammonia and trimethylamine is distilled out to separate monomethylamine and dimethylamine. Finally, trimethylamine is recovered by extractive distillation of the azeotropic mixture of ammonia and trimethylamine.
Trimethylamine is sold and used as a gas or as an aqueous solution, and has different safety and applicable regulations as well as properties.
In common with gases and aqueous solutions, both fall under the category of specified malodorous substances under the Malodor Prevention Act. In addition, when burned, they decompose to produce nitrous oxide, a toxic gas.
Other hazards include the following, so care must be taken when handling.
*Including some distributors, etc.
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Univar Solutions is a distributor and supplier of chemicals and ingredients since 1924 and are headquartered in Downers Grove, Illinois. The company provides a wide range of chemicals to customers and extends its value-added services to suppliers. The services include data sharing, digital marketing, lab and formulation capabilities, and more. As providers of chemicals their inventory is limitless with stocks of acids, enzymes, oxides, silicates, additives, and other ingredients and they offer packaging, product development, and custom blending besides the supplies. Overall industries like Food, Agriculture, Mining, Home and Industrial Cleaning, Pharmaceuticals, and lots more benefit from Univar Solutions.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Mitsubishi Gas Chemical Company Inc., established in 1918 and headquartered in Tokyo, Japan, is a chemical manufacturer that makes basic and fine chemicals and functional materials. The company has two business divisions, namely basic chemicals and functional chemicals, and its product portfolio includes electronic industry cleaning agents, MMA derivatives, hydrogen peroxide, xylene separation products, and laminated materials for printed circuit boards. In 1981, the company took the first step towards geothermal power development, and today, it is involved in geothermal power projects in five locations, including the 50,000-kilowatt Sumikawa Geothermal Power Plant, where it commenced operations in 1995.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Chemanol is a manufacturer of chemicals that was established in 1989, and is headquartered in Al Jubail, Saudi Arabia. Chemanol produces a wide range of specialty chemicals, including catalysts, additives, surfactants, polymers, and pharmaceuticals. The company's products are used by a number of industries, as diverse as agriculture, pharmaceuticals and construction, chemical, and automotive industries. Chemanol also provides a range of services to its customers, including custom synthesis, formulation of chemicals into many products, such as solutions, powders, and pellets, packaging specialty chemicals in a multiple containers, such as drums, bottles, and bags and logistics.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
SIAD Group, founded in 1927 and headquartered in Bergamo, Lombardy, is an Italian manufacturer and distributor specializing in industrial gases, as well as engineering and healthcare products and services. The company's product offerings include gases and gas mixtures for various industries. For instance, SIAD supplies specialty gases like high purity gases and noble gases to the electronic, environmental, petrochemical, and pharmaceutical sectors. SIAD also offers a range of refrigerant gases for air conditioning systems. SIAD also operates subsidiaries, such as SIAD Macchine Impianti S.p.A., which builds air separation units (ASUs), and SIAD HEALTHCARE SpA, which offers medical gases, surgical devices, and more.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Eastman Chemical was founded in 1920 and is headquartered in Kingsport, Tennessee. The company is a manufacturer and distributor of specialty chemicals, including coatings, adhesives, fibers, and plastics for industries such as automotive, medical, manufacturing, and construction. The company operates through four segments: Additives & Functional Products, Advanced Materials, Chemical Intermediates, and Fibers segments. Additives & Functional Products include food and fertilizer-based products. Advanced Materials include films and other chemicals used in transportation and electronics. Chemicals include phthalate plasticizers and other plastic products. Fibers include cigarette filters and other products.
Shanghai Theorem Chemical Technology Co., Ltd., established in 1997, is a company located in Shanghai, China, is a manufacturing company specializing in researching and manufacturing chemical new materials and fine chemicals. The company offers new functional materials, surfactants, polyurethane chemicals, special isocyanates, extractants, and more. They have a product chain advantage and offer professional technical support, and stable production supply with authorized ISO9001 quality management system, ISO14001 environmental management system, as well as related certifications. Their manufacturing factory with a land area of 80,000 m2, has over 300 workers, 30 engineers, 7 production workshops.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Alkyl Amines Chemicals Limited (AAC) is an Indian supplier of amine derivatives and specialty products that was established in Navi Mumbai, Maharashtra in 1979. The company produces various aliphatic amines such as propylamines and cyclohexylamines, as well as amine derivatives (e.g. nitriles, oximes). It also offers specialty chemicals for niche applications, including tertiary and chiral amines. Aside from its products, AAC also offers contract manufacturing and custom synthesis services to its clients, which mainly consists of companies in the petrochemical, rubber, agrochemical, and textile industries.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Chemanol |
16.1%
|
| 2 | Jigs chemical |
14.3%
|
| 3 | Univar Solutions Inc. |
12.5%
|
| 4 | Shanghai Theorem Chemical Technology Co., Ltd. |
8.9%
|
| 5 | Eastman Chemical Co. |
7.1%
|
| 6 | nacalai |
7.1%
|
| 7 | Alkyl Amines Chemicals Limited |
5.4%
|
| 8 | MilliporeSigma |
5.4%
|
| 9 | MITSUBISHI GAS CHEMICAL COMPANY, INC. |
5.4%
|
| 10 | SIAD |
3.6%
|
Derivation Method
The ranking is calculated based on the click share within the trimethylamine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
4 | 36.4% |
|
India
|
3 | 27.3% |
|
United States of America
|
2 | 18.2% |
|
Italy
|
1 | 9.1% |
|
China
|
1 | 9.1% |
