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This section provides an overview for triphenyl phosphite as well as their applications and principles. Also, please take a look at the list of 9 triphenyl phosphite manufacturers and their company rankings. Here are the top-ranked triphenyl phosphite companies as of December, 2024: 1.UPL, 2.Vesta Chemicals, 3.Merck.
Table of Contents
Triphenyl phosphite is an organophosphorus compound consisting of three phenyl groups bonded to a phosphorus atom.
Among the various existing manufacturing processes, the Friedel-Crafts reaction of benzene and phosphorus trichloride is used industrially. In the Friedel-Crafts reaction, an alkyl or acyl group is substituted for an aromatic compound.
Triphenyl phosphite is used in a wide variety of chemical reactions, most of which involve organic compounds.
Examples of chemical reactions using triphenyl phosphite include the Appel reaction and the Wittig reaction. Other examples include the Staudinger reaction, the Mitsunobu reaction, and the Heck reaction.
At room temperature, triphenyl phosphite is a crystalline white solid. It has a melting point of 80°C, a boiling point of 377°C, a density of 1.1 g/cm3, and a flash point of 180°C. It is relatively stable in air and soluble in non-polar organic solvents.
Its chemical formula is C18H15P with a molar mass of 262.29 g/mol, and it is sometimes called triphenylphosphane. The molecule has a triangular pyramidal shape.
Triphenyl phosphite reacts with alkyl halides (R-X) to give phosphonium salts. Phosphonium salts can react with strong bases to yield ylides.
The Staudinger reaction of triphenyl phosphite with azide gives rise to nitrogen, which forms a P=N bond; compounds with a P=N bond liberate an amine when reacted with water and an imine when reacted with carbonyl compounds.
In organic chemistry, triphenyl phosphite is used in various reactions. For example, the Appel reaction using triphenyl phosphite and carbon tetrachloride can alkylate almost all alcohols.
It is also used as a raw material for Wittig reagents. Today, the Wittig reaction is being used to develop various pharmaceuticals, particularly antibiotics.
In the Mitsunobu reaction, triphenyl phosphite can be used together with diethyl azodicarboxylate (DEAD) as a dehydration-condensation reaction.
Triphenyl phosphite is generally used as a precursor to organophosphorus compounds. Alkali metal diphenylphosphides can be obtained from triphenyl phosphite by reaction with alkali metals.
Alkali metal diphenylphosphides react with alkyl halides (R-X) to form RPh2P. Thus, diverse phosphine ligands can be synthesized, including methyl diphenylphosphine (MePh2P).
A similar reaction with alkyl dihalides yields bis(diphenylphosphino)alkanes. Specifically, the reaction of 1,2-dibromoethane with alkali metal diphenylphosphides yields 1,2-bis(diphenylphosphino)ethane.
On the other hand, a weaker acid such as ammonium chloride can be used to obtain diphenylphosphine from alkali metal diphenylphosphide.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
UPL was founded in 1969 and is headquartered in Mumbai, India, as a manufacturer of agricultural protection products. The company provides various products, including agrochemicals, seeds, industrial and specialty chemicals, and nitrified products. The company offers a range of industrial and specialized chemical products, such as caustic chlorine and white phosphorus. The company offers farmer advisory services through its Adarsh Kisan Centre, provides farmer advisory, training, and retail services through Unimart, and delivers farmer advice and spraying services under the Adarsh Farm Services trademarks.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Adishank Chemicals Pvt. Ltd. was founded in 2007 and is based in Maharashtra, India, is a manufacturer and supplier of specialty chemicals and additives for various industrial and commercial applications. The company's product folio includes a wide range of chemicals such as Triphenyl phosphite, Diisodecyl phenyl phosphite, Styrenated phenol, Diphenyl Isodecyl phosphite, and, Diphenyl iso-octyl phosphite that are essential in Surface Coating, Polymer, and Pharmaceutical Industries. The company also offers chemical compounds and additives such as Cresyl diphenyl phosphate and Tricresyl phosphate, which act as protective agents in organic synthesis.
Johoku Chemical, established in 1958 and headquartered in Tokyo, Japan, is a manufacturer and supplier of fine chemical products. The company offers over 150 products, including phosphites, acid phosphates, and benzotriazole compounds. Its products are generally used in various industries as a lubricating oil additive and corrosion inhibitor for several materials like copper, zinc, and as a raw material for medicinal intermediates. The company operates in compliance with ISO 9001 quality management guidelines.
Vesta Chemicals was established in 1988 and is based in Zwolle, Netherlands, is a supplier of catalysts and additives for various industrial applications in the chemical sector. The company provides catalysts such as azo-initiators, organic peroxides, phase transfer catalysts, triphenylphosphine, and tin catalysts that are compliant with the REACH standards and have applications in pharmaceutical, medical, electronics & power, and plastics manufacturing arenas. The company also offers complementary products such as phosphites, silanes, siloxanes, Aerogel, and, curing agents for the requirements in the chemical synthesis.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | UPL |
20.7%
|
| 2 | Vesta Chemicals |
20.7%
|
| 3 | Merck |
20.7%
|
| 4 | Adishank Chemicals Pvt. Ltd. |
13.8%
|
| 5 | Johoku Chemical |
10.3%
|
| 6 | KANTO CHEMICAL CO.,INC. |
6.9%
|
| 7 | Junsei Chemical Co.,Ltd. |
3.4%
|
| 8 | nacalai |
3.4%
|
Derivation Method
The ranking is calculated based on the click share within the triphenyl phosphite page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
5 | 62.5% |
|
India
|
2 | 25.0% |
|
Netherlands
|
1 | 12.5% |
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◼︎Attributes White scattered powder, soluble in alcohol, benzene and chloroform. Slightly soluble in esters. Barely soluble in water, toxic, LD50 8...
