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This section provides an overview for diphenhydramine as well as their applications and principles. Also, please take a look at the list of 7 diphenhydramine manufacturers and their company rankings. Here are the top-ranked diphenhydramine companies as of December, 2024: 1.KANTO CHEMICAL CO.,INC., 2.MilliporeSigma, 3.The Benadryl Advantage.
Table of Contents
Diphenhydramine is an organic compound, a tertiary amine with two phenyl groups and one ether group in the molecule.
It is represented by the chemical formula C17H21NO, and its CAS number is 58-73-1. It has a molecular weight of 255.355, a boiling point of 302-320°F (150~160°C) (266 Pa), and is a yellow liquid with a characteristic odor at room temperature.
The hydrochloride salt (diphenhydramine hydrochloride) is widely available on the market. This salt has a CAS number of 147-24-0, a molecular weight of 291.82, and a melting point of 332.6-340°F (167-171°C). At room temperature, it appears as a white crystal or crystalline powder and is soluble in water, ethanol, and acetic acid; somewhat insoluble in acetone; and almost insoluble in diethyl ether.
Diphenhydramine antagonizes histamine, which causes inflammation and is used as a drug to reduce inflammation, airway secretion, and sedation.
Diphenhydramine, an antihistamine (H1 receptor antagonist), antagonizes both peripheral and central histamine, resulting in the suppression of inflammation, airway secretion, and sedation. It is effective against urticaria, pruritus, and allergic rhinitis, including hay fever, mainly using its hydrochloride form.
Its side effect of inducing drowsiness has led to its use as a sleep-improving drug. In non-clinical applications, it is sometimes used as an antihistamine in experimental studies.
Diphenhydramine is synthesized by reacting diphenylmethylbromide with N,N-dimethylethanolamine, a nucleophilic substitution reaction under basic conditions.
Diphenhydramine, an antihistamine that antagonizes histamine H1 receptors, is used to relieve allergic symptoms caused by hay fever, colds, and urticaria. One of its notable side effects is drowsiness. It is also used as a sleep aid. However, its use for insomnia and long-term continuous use is not recommended. It is contraindicated in patients with glaucoma or obstructive diseases of the lower urinary tract.
Diphenhydramine is mainly used in its hydrochloride salt form as a drug. It is an ingredient in oral cold medicines, topical ointments, and injectable drugs. Indications include allergic rhinitis, urticaria, itching associated with skin diseases, acute rhinitis, and vasomotor rhinitis. Oral use is contraindicated in glaucoma patients and patients with obstructive diseases of the lower urinary tract.
Other products include research reagents, most sold as hydrochloride salts, with capacities ranging from small to large quantities. Diphenhydramine-d6 hydrochloride, a deuterium-replaced variant, is also available, requiring refrigerated storage, and is available in various capacities.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
TCI America (TCI) was founded in 1946 and is a worldwide manufacturer of specialty organic chemicals. The company produces organic laboratory chemicals as well as pharmaceutical, cosmetic, and functional materials. TCI’s product segments include Chemistry, Life Science, Materials Science, Analytical Chemistry, and Custom & Bulk. For materials science, the company manufactures battery materials, nanocarbon materials, and magnetic materials. For life sciences, the company produces antibodies, reagents, and chemicals for cancer research. The company produces HLC, NMR, various chemicals, and resins and media for analytical chemistry.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Fisher Scientific UK Ltd is a supplier of laboratory chemicals, equipment, and services based in Loughborough, United Kingdom, operating as a subsidiary of Thermo Fisher Scientific, a merger of Fisher Scientific International, Inc. and Thermo Electron in 2006. With a portfolio of over 2 million products, Fisher Scientific offers chemicals, reagents, equipment and instruments, consumables, and safety products. These products cater to various sectors, including clinical diagnostic and research laboratories, pharmaceutical and biotech industries, healthcare, and government agencies. Fisher Scientific also provides business solutions like the New-Lab Start-Up program, as well as SureTRACE and SureTRACE+ for product knowledge and supply chain management.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | KANTO CHEMICAL CO.,INC. |
37.5%
|
| 2 | MilliporeSigma |
28.1%
|
| 3 | The Benadryl Advantage |
12.5%
|
| 4 | Toronto Research Chemicals |
9.4%
|
| 5 | Tokyo Chemical Industry Co., Ltd. |
6.3%
|
| 6 | Fisher Scientific |
3.1%
|
| 7 | FUJIFILM Wako Pure Chemical Corporation |
3.1%
|
Derivation Method
The ranking is calculated based on the click share within the diphenhydramine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
3 | 60.0% |
|
Canada
|
1 | 20.0% |
|
United Kingdom
|
1 | 20.0% |
