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This section provides an overview for diphenidol hydrochloride as well as their applications and principles. Also, please take a look at the list of 10 diphenidol hydrochloride manufacturers and their company rankings. Here are the top-ranked diphenidol hydrochloride companies as of December, 2024: 1.CYMIT QUÍMICA S.L., 2.Quimica Alkano, 3.AdvaCare Pharma USA.
Table of Contents
Diphenidol hydrochloride is an organic compound with the chemical formula C21H27NO-HCl and a molecular weight of 345.91. It serves as an antidiarrheal agent, primarily used to treat vertigo associated with inner ear disorders, Meniere's disease, vestibular neuritis, and symptoms related to vestibular dysfunction.
Diphenidol hydrochloride, administered orally as a tablet or capsule, is taken three to four times daily. It effectively treats vertigo and alleviates symptoms of motion sickness, nausea, and vomiting, particularly post-surgery. Common side effects include mild and transient drowsiness, headache, dry mouth, and gastrointestinal symptoms like nausea, vomiting, and constipation.
Due to potential serious side effects and allergic reactions, patients should promptly report any unusual symptoms to their physician. Caution is advised when administering diphenidol hydrochloride to patients with glaucoma, obstructive urinary tract diseases, or gastrointestinal tract obstructions.
Diphenidol hydrochloride, with a molecular formula C21H27NO・HCl and molecular weight of 345.91, is a white crystalline powder almost insoluble in diethyl ether, slightly soluble in water, and soluble in ethanol and methanol. It decomposes at approximately 217°C.
The chemical name of diphenidol hydrochloride is "1,1-diphenyl-4-piperidin-1-ylbutan-1-ol monohydrochloride." It contains two phenyl groups, a hydroxyl group at its benzyl position, and is classified as a tertiary alcohol. The planar arrangement of the molecule is characterized by the two phenyl groups, while the piperidine ring and hydroxyl group contribute to its unique three-dimensional structure.
Synthesized in 1946 by Miescher et al., diphenidol hydrochloride is commonly manufactured through total synthesis. In Japan, it is marketed under the name "Cefadol Tablets" by Nippon Shinyaku Co.
Although not entirely clear, diphenidol hydrochloride is believed to alleviate vasoconstriction of the vertebral artery, increasing blood flow to improve the excitability imbalance between the left and right vestibular systems. It blocks abnormal impulses from the peripheral vestibular system at the vestibular nucleus and hypothalamus, correcting imbalances in the equilibrium system. Administered orally, it reaches peak blood levels in approximately 1.6 hours and has a half-life of about 6.5 hours.
*Including some distributors, etc.
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AdvaCare Pharma USA LLC, founded in 2014, is an American pharmaceutical manufacturer and supplier based in Cheyenne, Wyoming. The company specializes in a wide range of products, including over-the-counter (OTC) medicines, supplements, antimalarial tablets, injections, and oral suspensions. They also offer oncology tablets, injections, and powder for injections, as well as veterinary products and medical devices like injection instruments, diagnostic detection instruments, and skin and wound care products. AdvaCare's products are available under various brands, such as AmoxiCare™ for amoxicillin capsules and AdvaLife™ for supplements.
MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Fengchen Group Co., LTD is based in Qingdao, China. The company is a manufacturer and supplier of speciality chemicals for several industries around the world including natural resources, hydrogeology, drilling, geophysics, and environmental & geotechnical services. The company’s chemical product categories include APIs, amino acids, micronutrients, package materials, and enzymes. The company also offers services including specialized transportation, samples of compounds, shipping documents needed for pharmaceutical products, and international customs support.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | CYMIT QUÍMICA S.L. |
37.5%
|
| 2 | Quimica Alkano |
18.8%
|
| 3 | AdvaCare Pharma USA |
18.8%
|
| 4 | Toronto Research Chemicals |
12.5%
|
| 5 | MedChemExpress |
6.3%
|
| 6 | MilliporeSigma |
6.3%
|
Derivation Method
The ranking is calculated based on the click share within the diphenidol hydrochloride page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
3 | 37.5% |
|
Japan
|
2 | 25.0% |
|
Canada
|
1 | 12.5% |
Spain
|
1 | 12.5% |
Mexico
|
1 | 12.5% |
