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This section provides an overview for piperidine as well as their applications and principles. Also, please take a look at the list of 15 piperidine manufacturers and their company rankings. Here are the top-ranked piperidine companies as of December, 2024: 1.Vertellus, 2.Ganesh Group, 3.NSR laboratories Pvt. Ltd..
Table of Contents
Piperidine, an organic compound classified as a heterocyclic amine, has a chemical formula of C5H11N. It features a six-membered ring structure and is a colorless liquid at room temperature with a characteristic amine odor. Also known by names such as hexahydropyridine and pentamethyleneimine, piperidine is miscible with water and soluble in various organic solvents.
Piperidine's primary applications include serving as a vulcanization accelerator and solvent for rubber and as a curing agent for epoxy resins. Its simple molecular structure makes it a substructure of various pharmaceuticals, including morphine and fentanyl. In peptide solid-phase synthesis, piperidine is utilized for the deprotection reaction, especially in the Fmoc method.
Piperidine is industrially produced by reducing pyridine, typically through hydrogenation using a molybdenum(IV) sulfide catalyst or by the Birch reduction method.
It is commonly used in reactions to convert ketones to enamines, facilitating the Stork enamine reaction for alpha substitution in ketones. Piperidine is also widely employed as a solvent and base in synthetic organic chemistry.
Piperidine is highly flammable, with vapors heavier than air. It decomposes on burning, releasing toxic gases, and is corrosive to the eyes, skin, and respiratory tract. High concentrations can lead to pulmonary edema.
For research and development purposes, piperidine is available in various volumes, typically stored in glass bottles at room temperature. Due to its flammability and toxicity, careful handling is essential.
*Including some distributors, etc.
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Vertellus, established in 1857 and based in Indianapolis, Indiana, is a supplier of specialty chemical products and innovative materials. The company’s product portfolio includes pyridine and picolines, DEET, plastics, castor oil derivatives, and vitamin B3, among others. It serves industries in pharmaceuticals, medical devices, nutraceuticals, performance coatings, and transportation additives. In 2021, Vertellus expanded its solution portfolio in several high growth markets by acquiring IM Chemicals, Specialty Ingredients Businesses from Chemtrade, Jarchem Innovative Ingredients, and Polyscope Polymers.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
NSR Laboratories Pvt. Ltd., founded in 2019 in Kukatpally, Hyderabad, Telangana, is a manufacturer of specialty chemicals, API intermediates, CRO molecules, custom synthesis, and impurities for the chemical, pharmaceutical, and industrial sectors. The company produces amino acid derivatives, aromatic and heterocyclic compounds, key raw materials, and custom molecules in its research and development lab. The company has ISO 9001:2015 quality management systems certification and was awarded the Success Insights India Brand of The Year 2023.
Vasudha Pharma Chem Limited, founded in 1994 and headquartered in Telangana, India, is a manufacturer of active pharmaceutical ingredients (APIs) for domestic and international markets. The product line of the company includes pellets, under-development APIs, piperidone and piperidine derivatives, intermediates, and APIs utilized in the chemical and pharmaceutical industries. It has five manufacturing sites spread out over India with regulatory licenses from the USFDA, KFDA, Mexican MOH, and cGMP. In 2021 and 2022, the company got certifications for ISO 14001:2015, WHO GMP, ISO 45001:2018, and CEP.
Watanabe Chemical, established in 1951 and headquartered in Osaka, Japan, operates as a manufacturer and supplier of specialty chemicals and advanced materials. The company offers a diverse range of products including fluorinated chemicals, polyurethane additives, functional monomers, specialty resins, and surface modifiers. These products cater to various industries such as electronics, coatings, adhesives, and pharmaceuticals. It holds ISO 9001 certification, showcasing its adherence to quality management systems. The company also has its dark room lab with UV protection lamp to manufacture light-sensitive compounds.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Corey Organics was founded in 1994, and its headquarters is in Telangana, India, as a manufacturer of Active Pharmaceutical Ingredients (APIs), registered Pharma Intermediates, Fine Chemicals and Pyridine Derivatives for catering to the domestic as well as international market. Corey Organics has robust manufacturing facilities, and the company's management is commended to individuals with extensive experience and competence in manufacturing bulk medicines and the corresponding intermediates. This tactical approach ensures the delivery of superior products and fosters strong business relationships with clients across the globe.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Ganesh Group, established in 1991 and situated in Ankleshwar, Gujarat, India, is a manufacturer, exporter, and supplier of pigments, bulk drugs, and pharmaceutical intermediates to cater to the research and development purposes of companies. The group has seven subsidiaries: Ashok Pharma Chem, Ganesh Corporation, Shree Ganesh Chemicals, Shree Ganesh Remedies Limited, Praharit Pigments LLP, Shree Ganesh Pigments Pvt.Ltd, and Shree Ganesh Fibc Pvt. Ltd. The group accreditations are ISO 9001:2015, ISO 14001:2015, OHSAS 18001:2007 and is a member of Federation of Indian Export Organisation, Gujarat Chamber of Commerce, and Ankleshwar Industries Association.
KOEI CHEMICAL CO. LTD. established in 1917 and based in Tokyo, Japan, is a manufacturer and supplier specializing in the production of chemical products. The company's product portfolio includes ionic liquids, amines, formalin products, pyridines, and pyrazines. These chemicals are utilized in various sectors, including pharmaceuticals, agricultural chemicals, electronics, furniture manufacturing, and the paint and coatings industry. The company is ISO 9001 and ISO 14001 certified, and provides custom synthesis and technical support to its clients.
Catapharma, formed in 1986 and headquartered in Nashik, Maharashtra, India, is a manufacturer and supplier of fine chemicals and pharmaceutical intermediates. The company products include catechol derivatives, aliphatic amines, piperazine derivatives, amino acids, and cyclen derivatives used in pharmaceutical and chemical sectors. The firm has a quality control laboratory with analytical techniques, including GC, TLC, HPLC, and atomic photo spectrometers. In 2009, the company received the Green Chemistry Award in the Start-up to Medium Scale Enterprise Category.
BOC Sciences is headquartered in Shirley, New York as a brand of BOCSCI Inc. The company is a developer, manufacturer, marketer, and distributor of premium chemicals, emphasizing small molecule synthesis, biosynthesis, purification, and characterization used in academia, pharmaceuticals, biotech, CDMO, material sciences, and agriculture industries, supporting research and production. The company’s products include thousands of inhibitors, nucleotides, metabolites, and isotope-labeled products. The company offers custom synthesis and manufacturing, analytical services, antibody-drug conjugate development, and strain engineering and fermentation services.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Anant Pharmaceuticals Pvt. Ltd., established in 2005, is a supplier of pharmaceutical impurity reference samples and custom synthesis and analytical services, based in India. The company delivers novel solutions to research and development teams. Their organic synthesis labs are equipped with modern equipment, designed with energy saving concept. Over the years, they have developed into a one-stop service provider for bespoke chemical synthesis and analytical services for a wide range of industries in India and abroad.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Ganesh Group |
18.2%
|
| 2 | Vertellus |
18.2%
|
| 3 | NSR laboratories Pvt. Ltd. |
12.4%
|
| 4 | Vasudha Pharma Chem Limited |
8.3%
|
| 5 | Junsei Chemical Co.,Ltd. |
6.6%
|
| 6 | Corey Organics |
5.8%
|
| 7 | BOC Sciences |
5.0%
|
| 8 | Anant Pharmaceuticals Pvt. Ltd. |
5.0%
|
| 9 | Watanabe Chemical |
4.1%
|
| 10 | MilliporeSigma |
4.1%
|
Derivation Method
The ranking is calculated based on the click share within the piperidine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
5 | 50.0% |
|
Japan
|
4 | 40.0% |
|
United States of America
|
1 | 10.0% |
