12 Dihydropyran Manufacturers in 2024
This section provides an overview for dihydropyran as well as their applications and principles. Also, please take a look at the list of 12 dihydropyran manufacturers and their company rankings. Here are the top-ranked dihydropyran companies as of November, 2024: 1.Wilshire Technologies, 2.SRL, 3.KANTO CHEMICAL CO.,INC..
Table of Contents
What Is Dihydropyran?
Dihydropyran is a cyclic ether with the molecular formula C5H8O, featuring a six-membered ring structure containing one oxygen atom and one double bond.
Several structural isomers of dihydropyran exist, but the most commonly referenced form is 3,4-dihydro-2H-pyran.
Uses of Dihydropyran
Dihydropyran serves as a crucial raw material and reagent in organic synthesis, particularly in protecting the hydroxyl groups of alcohols and phenols. It reacts with alcohols, under acidic catalysts, to form tetrahydropyranyl groups, which act as protective moieties for alcohols. Additionally, it is employed in the production of tetrahydropyran and tetrahydropyranyl ether.
Properties of Dihydropyran
1. Synthesis of 3,4-Dihydro-2H-Pyran
3,4-dihydro-2H-pyran is obtained by heating tetrahydrofurfuryl alcohol with aluminum oxide at temperatures ranging from 300 to 400°C.
2. Basic Information on 3,4-Dihydro-2H-Pyran
3,4-dihydro-2H-pyran, with a molecular weight of 84.12, appears as a colorless to yellow liquid with an ethanol odor at room temperature. It has a melting point of -70°C and a boiling point of 86°C. This compound is highly soluble in ethanol and acetone but insoluble in water. Due to its flammability, it is classified under various safety laws.
3. 3,6-Dihydro-2H-Pyran Basic Information
3,6-dihydro-2H-pyran, with a molecular weight of 84.12, has a boiling point of 92-93°C and a density of 0.943 g/mL. Its CAS registration number is 3174-74-1.
4. Chemical Reaction of 3,4-Dihydro-2H-Pyran
Dihydropyran undergoes hydrogenation using Raney nickel to yield tetrahydropyran. Moreover, under nonaqueous conditions and in the presence of an acid catalyst, 3,4-dihydro-2H-pyran reacts with alcohols to form tetrahydropyranyl ethers, serving as protective groups for alcohols. Deprotection of the tetrahydropyranyl group typically involves acid treatment with water or a large excess of methanol or ethanol instead of water.
5. Tetrahydropyranyl Group
The tetrahydropyranyl group, utilized to protect alcohols, exhibits stability under various conditions except for acidic environments. While cost-effective and easily deprotected under weakly acidic conditions, it introduces complexity in chiral alcohols, affecting NMR spectra and yielding isomeric diastereomers due to its chiral carbon.
Types of Dihydropyrans
Dihydropyran is primarily available as a reagent product for research and development. Although 3,4-dihydro-2H-pyran is the predominant form, derivatives of 3,6-dihydro-2H-pyran, such as the pinacol ester of boronic acid, are also commercially available. 3,4-dihydro-2H-pyran is typically offered in volumes ranging from 25 mL to 500 mL, and it is stored refrigerated or frozen as a reagent product.
List of 12 Dihydropyran Manufacturers
*Including some distributors, etc.
Sort by Features
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- Company Size: largest first
- Year Founded: oldest first
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- United States of America
- Canada
- India
- Japan
- United Kingdom
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AK Scientific, Inc
Dihydropyran
Manufacturer Overview
AK Scientific, Inc. (AKS) is an American advanced intermediates and fine chemicals manufacturer that was established in Union City, California in 1997. The company’s product lineup includes chemical biocides, bioactives, inhibitors, and reagents. It also offers a range of products for use in life science applications, such as screening compounds, organoborons, and molecular fluorophores. These are extensively used in agrochemicals, biotech, pharmaceuticals, and nanotechnology. Aside from its products, AKS also offers international procurement and sourcing services to its clients, which include AstraZeneca, Sanofi-Aventis, and Bristol-Myers Squibb.
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Molekula Americas LLC
3,4-Dihydropyran
Company Overview
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
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KANTO CHEMICAL CO.,INC.
2,3-Dihydropyran
Manufacturer Overview
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
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Junsei Chemical Co.,Ltd.
Dihydropyran
Manufacturer Overview
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
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Pharmaffiliates
2,3-Dihydropyran
Manufacturer Overview
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
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Toronto Research Chemicals
Dihydropyran
Manufacturer Overview
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
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Merck
3,4-Dihydro-2H-pyran
Manufacturer Overview
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
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MilliporeSigma
Dihydropyran
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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nacalai
3,4-Dihydro-2H-pyran
Company Overview
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
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Alfa Aesar, Thermo Fisher Scientific.
L02731 3,4-Dihydro-2H-pyran, 99%
Company Overview
Alfa Aesar is based in Lancashire, United Kingdom. Alfa Aesar is part of Thermo Fisher Scientific, is a manufacturer and supplier of chemicals, metals, and life science products for research and development. Alfa Aesar’s product lines include chemicals, life science, materials & metals, catalysts, and analytical & lab ware. Chemical offerings include inorganic compounds, organic compounds, organometallic, and solvents. Life sciences include biotechnology products, cellular & molecular biology, genomics, and immunology. Materials & metal include alloys, carbon, etchants, and more. Catalysts include ferrocenes, fuel cell products, and precious metals & catalysts. Alfa Aesar also offers custom manufacturing options.
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Company Overview
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
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Wilshire Technologies
Dihydropyran
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Dihydropyran Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Wilshire Technologies |
25.0%
|
| 2 | SRL |
25.0%
|
| 3 | Alfa Aesar, Thermo Fisher Scientific. |
25.0%
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| 4 | KANTO CHEMICAL CO.,INC. |
25.0%
|
Derivation Method
The ranking is calculated based on the click share within the dihydropyran page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- KANTO CHEMICAL CO.,INC.: 1,062
- Junsei Chemical Co.,Ltd.: 171
Newly Established Company
- Pharmaffiliates: 2001 (23 years ago)
- Toronto Research Chemicals: 1982 (42 years ago)
- SRL: 1975 (49 years ago)
Company with a History
- nacalai: 1934 (90 years ago)
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- Junsei Chemical Co.,Ltd.: 1948 (76 years ago)
Dihydropyran Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Dihydropyran Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
Japan
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3 | 33.3% |
United States of America
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2 | 22.2% |
India
|
2 | 22.2% |
Canada
|
1 | 11.1% |
United Kingdom
|
1 | 11.1% |
