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This section provides an overview for citral as well as their applications and principles. Also, please take a look at the list of 13 citral manufacturers and their company rankings. Here are the top-ranked citral companies as of December, 2024: 1.NATIONAL ANALYTICAL CORPORATION, 2.Central Drug House, 3.Kuraray Co., Ltd..
Table of Contents
Citral is the name given to a mixture of a pair of isomers, the organic compounds neral and geranial. Its IUPAC nomenclature name is 3,7-dimethyl-2,6-octadienal, and it is also sometimes referred to by the alias lemonal.
Both isomers are monoterpene aldehydes with the molecular formula C10H16O and are cis-trans isomers: E is geranial and Z is neral. The CAS registration number of citral is 5392-40-5.
Citral has a lemon-like aroma, so it is used as an excipient in cosmetics and foods, as well as in various products such as perfumes, cosmetics, facial cleansers, body soaps, shampoos, detergents, and foods.
In natural products, it is a substance present in essential oils of lemongrass, lemon, mandarin, and various other fruits and spices. Because of its high volatility and strong aroma, it is used in top notes, which are the first to be perceived in fragrance formulations.
It is also used as a raw material for the production of other flavors and fragrances.
Citral is also a useful compound as a raw material for general organic synthesis. It is used as a raw material for synthesizing chemicals such as vitamin A and vitamin E
Citral is a mixture of geranial and neral. It has a molecular weight of 152.24, a melting point below -10°C, and a boiling point of 229°C. It is a colorless to pale yellow liquid at room temperature. It is susceptible to oxidation and gradually takes on a yellowish color upon exposure to air. It has a density of 0.893 g/mL
Citral is easily soluble in ethanol and ether, but insoluble in water. It has a characteristic aroma, of which geranial has a cool, strong lemon odor, while neral has a weak lemon odor and sweet taste.
Citral is generally sold as a reagent product for research and development and as a raw material for fragrances. As a reagent product for research and development, it is available in various capacities, such as 1mg, 5mg, 5mL, 100mL, 500mL, 25g, 1kg, etc., depending on the manufacturer.
Reagent products may be treated as refrigerated reagents or as reagents that can be handled at room temperature.
Note that reagent products can only be used for research and development purposes, not for medical, clinical diagnostic, or food use in humans or animals.
Industrial products are sold by several companies, including fragrance and chemical manufacturers.
Sales are developed in a variety of packing sizes ranging from 1L bottles to ultra-large capacities such as 25L drums, 180kg drums, and 200L drums. The product offerings are tailored to factories and other manufacturing sites.
Citral is contained in various essential oils, so it can be produced by separation from essential oils. It can also be produced synthetically, sometimes using methyl heptenone as a raw material.
The following synthetic route is an example of synthesis:
One other synthetic example is via the dehydrolinalool intermediate produced by the condensation reaction of acetylene with methyl heptenone. This intermediate is rearranged at 140-150°C in the presence of a silicon sulfone catalyst in an inert solvent to give citral.
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
GlpBio Technology, established in 2016 and headquartered in Montclair, California, is a supplier of life science products covering 20 popular research fields, including epigenetics, neuroscience, and cancer. Its product portfolio has over 20,000 life science reagents, including biochemicals, tag peptides, bioactive peptides, amino acids, and nature products. Its main clients include clinical diagnostic laboratories, government agencies, research institutes, universities, and pharmaceutical companies. The company regularly increases its products to meet the latest research needs and provides custom organic synthesis and analytical services.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Berjé Inc. was originally founded in 1949 and is headquartered in Carteret, New Jersey. The company is a national wholesaler of over 2000 essential oils and aromatic chemicals sourced from local farmers around the world. The company has two product categories: essential & fixed oils and aromatic chemicals. Essential & fixed oils include essential oils and fixed oils while aromatic chemicals include natural aromatics and all aromatic chemicals. The company lists chemicals by four application categories which are flavor ingredients, fragrance ingredients, functional ingredients, and fragrances.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Kuraray Co., Ltd., founded in, Tokyo, Japan, in 1926 is a manufacturer of PVOH, PVB and EVOH resin and film. The company's product portfolio includes methacrylic resin, isoprene chemicals, elastomer, polyamide resin, and medical products. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. The company has offices in the USA, Europe and China and they have global sales and distribution channels.
Kalpsutra chemicals Pvt. Ltd., established in 1986, based in Mumbai, India, is a manufacturer and exporter of industrial inorganic chemicals. The company’s aroma chemicals and flavor ingredients products portfolio includes aldehydes, ketones, alcohol and acetate, nitriles, oxide, and acids. The company serves the flavors and fragrance industries worldwide. High efficiency equipment is used to produce quality standardized products. The company is the largest manufacturer of aroma chemicals in India, with manufacturing units located in Gujarat.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Starsky international holdings Co., Ltd., established in 1984 and headquartered in Shanghai, China, is a manufacturer of organic and inorganic chemicals. The company provides APIs, organic and inorganic chemicals, food additives, fragrances and catalysts with customized service based on customers’ demands. It has two production facilities and complies with quality standards including ISO 9001 and 14001, GMP and Kosher. With independent export rights, the company exports its products to over 100 countries including USA, England, France, Germany and Thailand.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Odowell is a Chinese company that specializes in the production and distribution of health wellness products. Established in 2004, the main products include blood glucose meters, blood pressure monitors, and infrared thermometers. ODOWELL provides affordable healthcare solutions to customers worldwide. With research and development, the company has earned a reputation for innovation and reliability in the healthcare industry. ODOWELL's customer satisfaction and its dedication to improving healthcare globally make it a reputable brand.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | NATIONAL ANALYTICAL CORPORATION |
19.2%
|
| 2 | Central Drug House |
14.1%
|
| 3 | Kuraray Co., Ltd. |
10.3%
|
| 4 | KUNSHAN ODOWELL CO.,LTD |
9.0%
|
| 5 | Kalpsutra chemicals Pvt. Ltd. |
9.0%
|
| 6 | MilliporeSigma |
9.0%
|
| 7 | BERJÉ INC |
6.4%
|
| 8 | Merck |
6.4%
|
| 9 | GLPBIO Technology LLC |
5.1%
|
| 10 | Santa Cruz Biotechnology, Inc. |
3.8%
|
Derivation Method
The ranking is calculated based on the click share within the citral page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
4 | 40.0% |
|
India
|
3 | 30.0% |
|
Japan
|
2 | 20.0% |
|
China
|
1 | 10.0% |
