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This section provides an overview for chenodeoxycholic acids as well as their applications and principles. Also, please take a look at the list of 12 chenodeoxycholic acid manufacturers and their company rankings. Here are the top-ranked chenodeoxycholic acid companies as of December, 2024: 1.Tianjin NWS Biotechnology and Medicine Co. Ltd., 2.SimSon Pharma Limited, 3.Cayman Chemical Company.
Table of Contents
Chenodeoxycholic acid, a primary bile acid produced in the liver of birds, mammals, and fish, plays a crucial role in the digestion and absorption of fats. Its IUPAC name is 3α,7α-Dihydroxy-5β-cholan-24-oic acid, also known as chenodiol or CDCA. Derived from the Greek word "keno" for duck, it was first isolated from this source.
As a significant bile acid, chenodeoxycholic acid is utilized to dissolve gallstones made primarily of cholesterol. Administered orally, it helps dissolve small to medium-sized gallstones by promoting bile flow. However, it is not effective against large or calcified gallstones. Common side effects include diarrhea, nausea, and potential liver function abnormalities. Caution is advised when used with certain medications, including those for diabetes and cholesterol management.
Chenodeoxycholic acid has shown efficacy in managing cerebrotendinous xanthomatosis, a rare metabolic disorder, by improving cholestanol levels. Early treatment can mitigate symptoms like Achilles tendon thickening and neurological issues.
With the chemical formula C24H40O4 and a molecular weight of 392.57, chenodeoxycholic acid is a white crystalline powder. It has a melting point of 165-167°C and exhibits solubility in ethanol, acetone, and acetic acid but is sparingly soluble in water.
Chenodeoxycholic acid can be synthesized from cholic acid through esterification, protection, oxidation, and reduction steps, including the Wolff-Kichner reduction to remove the carbonyl group. It can also be extracted and purified from porcine bile.
Take care to avoid exposure to strong oxidizing agents when handling chenodeoxycholic acid. Use protective equipment and ensure good hygiene practices. In case of fire, employ appropriate extinguishing methods. For skin contact, wash thoroughly and seek medical attention if irritation persists. Store the compound in a cool, light-shielded environment to prevent degradation.
*Including some distributors, etc.
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Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
ICE S.p.a., founded in 1949 and headquartered in Reggio Emilia, Italy, is a manufacturer specializing in active pharmaceutical ingredients, with a particular interest in Ursodeoxycholic Acid (UDCA), a vital component for treating liver diseases and gallstones. The company offers a comprehensive and diverse product portfolio, which includes plant-origin bile acids and carbohydrate derivatives, oral liquid, and solid finished dosage forms. These pharmaceutical ingredients serve numerous critical functions, including acting as selective inhibitory agents in bacteriological media, aiding in the treatment of gastrointestinal disorders and chronic dermatoses, supporting medical research and clinical development, and facilitating fat solubilization and digestion.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Angle BioPharma, established in 2017 and based in Gujarat, India, is a manufacturer, distributor, and supplier of pharmaceutical API and pharmaceutical intermediate products. The company manufactures various other pharma products such as Levothyroxine Sodium, Ezetimibe, Bleomycin Sulfate, Bortezomib, and Cetrorelix Acetate and supplies to Pakistan and Bangladesh doctors and pharmacists. The company produces pharma products to treat various diseases. The company also produces and supplies active pharma ingredients, API raw products, API raw materials, and product materials.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
CD Bioparticles, founded in Shirley, New York, is a manufacturer of biocompatible drug delivery systems. The company's product portfolio includes Liposomes, PEGylated liposomes, Polymer microspheres, Nanoparticles and Functional Biomedical Coatings. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. They also provide Contract services of drug delivery formulation developments, Product Selection Guidance, customer support, custom research projects and customized services.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Tianjin NWS Biotechnology and Medicine Co. Ltd. |
23.1%
|
| 2 | SimSon Pharma Limited |
15.4%
|
| 3 | Cayman Chemical Company |
15.4%
|
| 4 | MilliporeSigma |
15.4%
|
| 5 | KANTO CHEMICAL CO.,INC. |
15.4%
|
| 6 | Jigs chemical |
7.7%
|
| 7 | NATIONAL ANALYTICAL CORPORATION |
7.7%
|
Derivation Method
The ranking is calculated based on the click share within the chenodeoxycholic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
India
|
4 | 44.4% |
|
Japan
|
2 | 22.2% |
|
United States of America
|
1 | 11.1% |
|
Italy
|
1 | 11.1% |
China
|
1 | 11.1% |
