10 Cholesterol Manufacturers in 2024
This section provides an overview for cholesterol as well as their applications and principles. Also, please take a look at the list of 10 cholesterol manufacturers and their company rankings. Here are the top-ranked cholesterol companies as of November, 2024: 1.Nature Science Technologies, 2.Alfa Chemistry, 3.Evonik Industries AG.
Table of Contents
What Is Cholesterol?
Cholesterol is an organic compound with a steroidal structure. It is an essential component of cell membranes in animal cells. It is also a raw material for steroid hormones, sex hormones, and bile acids that promote fat absorption.
Since it is insoluble in blood, it must be transported in the form of particles called lipoproteins. Lipoproteins include LDL (low-density lipoprotein) and HDL (high-density lipoprotein), and the corresponding cholesterol is called LDL cholesterol and HDL cholesterol, respectively.
Uses of Cholesterol
The main uses of cholesterol are as a raw material for cosmetics, pharmaceuticals, and industrial products.
In cosmetics, cholesterol is used in creams and emulsions, and in pharmaceuticals, it is used in oral and topical formulations (e.g., anti-inflammatory ointments).
The esters of cholesterol and fatty acids have liquid crystalline properties. This is applied to industrial products in the form of liquid crystal materials called cholesteric liquid crystals. Cholesteric liquid crystals are used in electronic paper display technology and temperature sensors.
Properties of Cholesterol
Cholesterol is a white to pale yellow crystal with chemical formula C27H46O and a molecular weight of 386.65. It is lipophilic, nearly insoluble in water, and has a melting point of 149℃.
The coloring reaction can be seen in the Salkowski reaction and the Liebermann-Burchard reaction. In the Salkowski reaction, cholesterol is dissolved in chloroform and mixed with concentrated sulfuric acid. The chloroform layer turns red and the sulfuric acid layer turns yellow and fluoresces green.
In the Liebermann-Burchard reaction, cholesterol is dissolved in chloroform, a few drops of acetic anhydride are added, and then a few drops of concentrated sulfuric acid are added and mixed. The chloroform layer turns rose-colored and eventually turns green.
Structure of Cholesterol
Cholesterol has a steroidal skeleton consisting of three six-membered rings and one five-membered ring.
Cholesterol is a sterol because it has a hydroxyl group at position 3 of the steroid skeleton.
Other Information on Cholesterol
1. How It Is Synthesized in the Body
Cholesterol is mainly synthesized in the liver from the three major nutrients (carbohydrates, proteins, and fats). Acetyl coenzyme A is the first product of the breakdown of the three macronutrients.
Acetyl CoA is converted to mevalonic acid by the action of several enzymes. Mevalonic acid undergoes several chemical reactions to produce squalene, which has a steroidal skeleton. Squalene undergoes several more chemical reactions and is finally converted to cholesterol.
2. Absorption in the Body
Cholesterol ingested from food is absorbed in the small intestinevia a protein called cholesterol transporter.
3. Action in the Body (LDL Cholesterol)
LDL cholesterol carries cholesterol to the cells and tissues of the body. When the amount of LDL cholesterol in the blood increases due to some abnormality, LDL cholesterol accumulates and oxidizes in the walls of blood vessels. The result is atherosclerosis.
LDL cholesterol is also called bad cholesterol because it promotes atherosclerosis.
4. Action in the Body (HDL Cholesterol)
The function of HDL cholesterol is to collect unwanted cholesterol in cells and cholesterol deposited in blood vessel walls and return it to the liver.
HDL cholesterol is also called good cholesterol because it inhibits atherosclerosis.
5. Criteria for Blood Cholesterol Levels
When the levels of LDL cholesterol and HDL cholesterol meet the following criteria, dyslipidemia is suspected.
- LDL Cholesterol: 140 mg/dl or higher
- HDL Cholesterol: less than 40 mg/dl
List of 10 Cholesterol Manufacturers
*Including some distributors, etc.
Sort by Features
- Default
- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- Germany
- Japan
- United States
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Molekula Americas LLC
Cholesterol
Company Overview
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
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Nature Science Technologies
Cholesterol
Distributor Overview
Nature Science Technologies, established in 2017 in the USA, is a supplier and distributor of natural origin chemicals and plant extract compounds. It specializes in bioorganic and medicinal chemicals, providing dietary supplements to the food and pharmaceutical industries. Its product range includes a variety of extracts such as artichoke leaf, bamboo leaf, blueberry, citrus, and Dan-Shen, among others. The astragalus extract enhances immune system function, reduces inflammation, and promotes healthy aging. D-raffinose pentahydrate is primarily used for skin rejuvenation and serves as a nutrient source for yeast and bacteria.
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KANTO CHEMICAL CO.,INC.
Cholesterol
Manufacturer Overview
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
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Junsei Chemical Co.,Ltd.
Cholesterol
Manufacturer Overview
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
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Kishida Chemical Co.,Ltd.
Cholesterol
Manufacturer Overview
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
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Alfa Chemistry
Cholesterol
Manufacturer Overview
Alfa Chemistry, founded in the year 2015 is based in New York, USA as a biotechnology company and manufacturer of graphene materials. Their product portfolio includes graphene oxide, CVD graphene film, graphene modification services, graphene series, graphene-like material, carbon nanomaterials, quantum dots, upcoming nanoparticles, and graphene transfer services. The company also provides services in custom manufacturing, and graphene analysis with quality assurance. The products are used in various industries which include energy, digital electronics, environment, textile, coating, and biomedical science.
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Merck
Cholesterol
Manufacturer Overview
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
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MilliporeSigma
Cholesterol
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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nacalai
Cholesterol
Company Overview
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
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Evonik Industries AG
Cholesterol
Company Overview
Evonik Industries AG, founded in 2007 and headquartered in Essen, North Rhine-Westphalia, is a manufacturer and supplier of pharmaceutical, and medical device. The company offers an extensive product catalog, which includes active pharmaceutical ingredients, bioresorbable medical devices, cell culture ingredients, excipients for oral solid dosage forms, and formulation development services. These products serve various critical applications, ranging from providing oral drug delivery solutions to enhance the efficacy of active pharmaceutical ingredients (API), functional coatings for improved nutraceutical performance and preference, biodegradable polymers for implantable medical devices, to surface modification technology that enhances the functionality and safety of medical devices.
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Cholesterol Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Nature Science Technologies |
26.9%
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| 2 | Alfa Chemistry |
14.1%
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| 3 | Evonik Industries AG |
10.3%
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| 4 | Molekula Americas LLC |
10.3%
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| 5 | KANTO CHEMICAL CO.,INC. |
10.3%
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| 6 | Junsei Chemical Co.,Ltd. |
7.7%
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| 7 | Merck |
7.7%
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| 8 | Kishida Chemical Co.,Ltd. |
6.4%
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| 9 | nacalai |
3.8%
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| 10 | MilliporeSigma |
2.6%
|
Derivation Method
The ranking is calculated based on the click share within the cholesterol page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- Evonik Industries AG: 33,000
- KANTO CHEMICAL CO.,INC.: 1,062
- Kishida Chemical Co.,Ltd.: 283
Newly Established Company
- Junsei Chemical Co.,Ltd.: 1948 (76 years ago)
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- nacalai: 1934 (90 years ago)
Company with a History
- nacalai: 1934 (90 years ago)
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- Junsei Chemical Co.,Ltd.: 1948 (76 years ago)
Cholesterol Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Cholesterol Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
Japan
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4 | 50.0% |
United States of America
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2 | 25.0% |
| United States | 1 | 12.5% |
Germany
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1 | 12.5% |
