11 Cholic Acid Manufacturers in 2024
This section provides an overview for cholic acid as well as their applications and principles. Also, please take a look at the list of 11 cholic acid manufacturers and their company rankings. Here are the top-ranked cholic acid companies as of November, 2024: 1.Fengchen Group Co.,Ltd, 2.Manus Aktteva Biopharma LLP, 3.Cayman Chemical Company.
Table of Contents
What Is Cholic Acid?
Figure 1. Basic information on cholic acid
Cholic Acid is a bile acid with a chemical formula of C24H40O5. It is typical of steroids.
The liver can synthesize cholic acid and chenodeoxycholic acid, the primary bile, from cholesterol. They also form conjugates with the amino acids glycine and taurine, and are secreted into the duodenum as bile components.
The secreted primary bile acids can be released from glycine and taurine by the action of intestinal bacteria in the small intestine. They are then converted to deoxycholic acid and lithocholic acid, called secondary bile acids, which are returned to the liver from the terminal end of the small intestine.
Uses of Cholic Acid
Animal bile has been used in herbal medicine since ancient times. Among them, bear bile, made from dried bear bile, is said to be effective for pain near the gallbladder, one of the three most painful conditions. Its main ingredient is ursodeoxycholic acid, a secondary bile acid.
Cholic acid is used as a medicine. Ursodeoxycholic acid is used as a gastrointestinal drug, while chenodeoxycholic acid is used as a drug therapy for cholesterol-based gallstone dissolution and as a gastrointestinal drug.
Properties of Cholic Acid
Cholic Acid is slightly soluble in water. Its melting point is 200-201°C and boiling point is 583-584°C.
When recrystallized with dilute acetic acid, it produces a plate-like crystal with one molecule of crystalline water. When recrystallized from alcohol, crystals with a single molecule of alcohol are produced; heating to 130°C removes the crystalline solvent and can produce an anhydride.
It emulsifies water-insoluble substances such as fats in the intestinal tract, thereby aiding digestion and absorption and facilitating enzymatic action. It is present in the bile of most vertebrates in peptide bonds with glycine or taurine.
Structure of Cholic Acid
Cholic Acid is a steroid that forms amides with amino acids and is found in many organisms. Steroids are naturally occurring triterpenoids. Terpenoids are derivatives of isoprene-based hydrocarbons, terpenes, that have functional groups such as hydroxy and carbonyl groups.
Cholic Acid is also called 3α,7α,12α-trihydroxy-5β-cholan-24-oic acid. Its molecular weight is 408.579 g/mol and its density is 1.2 g/cm3.
Other Information on Cholic Acid
1. Glycolic Acid in the Body
Cholic Acid is usually condensed with amino acids and exists as a conjugated bile acid. In humans, the majority are glycocholic acid and taurocholic acid. Cholic Acid in its raw form can cause tissue damage.
2. Characteristics of Cholic Acid
Figure 2. Basic information on glycolic acid
Glycolic Acid is a conjugated bile acid that is a condensation of cholic acid and glycine. It accounts for about two-thirds of human bile acids and is a transparent bile acid capable of emulsifying fats.
It is biosynthesized by the reaction of glycine and choryl CoA. Its chemical formula is C26H43NO6, its molecular weight is 465.6 g/mol, and its melting point is 130°C. It is a bile acid of mammals and also exists transformed to its sodium salt.
3. Characteristics of Taurocholic Acid
Figure 3. Basic information on taurocholic acid
Taurocholic acid is a conjugated bile acid that is a condensation of cholic acid and taurine. It is a clear yellow bile acid with fusible properties and accounts for about one-third of human bile acids. It is biosynthesized by the reaction of taurine and cholic acid. Its chemical formula is C26H45NO7S, its molecular weight is 515.7 g/mol, and its melting point is 125.0°C.
Medicinally, it is used as a cholecystokinin and diuretic. Commercially, it can be produced from bovine bile, a byproduct of the meat industry. The 50% lethal dose (LD50) in newborn rats is 380 mg/kg.
List of 11 Cholic Acid Manufacturers
*Including some distributors, etc.
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- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
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- United States of America
- India
- Italy
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Cayman Chemical Company
Cholic Acid
Manufacturer Overview
Cayman Chemical Company is a manufacturer of life science research products founded in 1979 in Ann Arbor, Michigan, USA. They offer a diverse array of analytical standards, reagents, and other products for research in cancer, oxidative injury, epigenetics, neuroscience, inflammation, as well as metabolism, and other areas. The company supplies small molecules, biochemicals, assay kits, antibodies, and proteins to research scientists across academic, biotechnology, and pharmaceutical institutions. Cayman Chemical Company holds dual accreditations to ISO/IEC 17025:2017 and ISO 17034:2016 by ANAB Accreditation Services.
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Manus Aktteva Biopharma LLP
Cholic Acid
Manufacturer Overview
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
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Bacto Chem Laboratories
Cholic Acid
Manufacturer Overview
Bacto Chem Laboratories, established in 1972 and based in Hyderabad, India, is a manufacturer known for producing various quality bio-pharmaceutical products and formulations. The company's journey began with the manufacturing of biological extracts, such as peptones, liver extracts, stomach extracts, and ox-bile extracts. It produces bulk quantities of superior quality with optimized use of raw materials using ultra-modern technology. The company has evolved its product portfolio to include critical pharmaceutical components like heparin sodium, enoxaparin sodium, liver injection crude, chondroitin sulfate, and cholic acid derivatives.
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Titan Biotech Limited
Cholic Acid
Manufacturer Overview
Titan Biotech Limited is based in Delhi, India, and has been a manufacturer and exporter of various biological products since its establishment in 1992. The company offers a range of products such as ox-bile extract, protein hydrolysates, amino acid mixtures, liver extracts, plant growth promoters, and more. These products are used in diverse industries, including food and beverages, biotechnology and fermentation, veterinary and animal feed, microbiology culture media, and plant tissue culture media.
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ICE S.p.a.
Cholic Acid
Manufacturer Overview
ICE S.p.a., founded in 1949 and headquartered in Reggio Emilia, Italy, is a manufacturer specializing in active pharmaceutical ingredients, with a particular interest in Ursodeoxycholic Acid (UDCA), a vital component for treating liver diseases and gallstones. The company offers a comprehensive and diverse product portfolio, which includes plant-origin bile acids and carbohydrate derivatives, oral liquid, and solid finished dosage forms. These pharmaceutical ingredients serve numerous critical functions, including acting as selective inhibitory agents in bacteriological media, aiding in the treatment of gastrointestinal disorders and chronic dermatoses, supporting medical research and clinical development, and facilitating fat solubilization and digestion.
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Merck
Cholic acid
Manufacturer Overview
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
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Fengchen Group Co.,Ltd
Cholic Acid
Manufacturer Overview
Fengchen Group Co., LTD is based in Qingdao, China. The company is a manufacturer and supplier of speciality chemicals for several industries around the world including natural resources, hydrogeology, drilling, geophysics, and environmental & geotechnical services. The company’s chemical product categories include APIs, amino acids, micronutrients, package materials, and enzymes. The company also offers services including specialized transportation, samples of compounds, shipping documents needed for pharmaceutical products, and international customs support.
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Angle Bio Pharma
Cholic Acid
Company Overview
Angle BioPharma, established in 2017 and based in Gujarat, India, is a manufacturer, distributor, and supplier of pharmaceutical API and pharmaceutical intermediate products. The company manufactures various other pharma products such as Levothyroxine Sodium, Ezetimibe, Bleomycin Sulfate, Bortezomib, and Cetrorelix Acetate and supplies to Pakistan and Bangladesh doctors and pharmacists. The company produces pharma products to treat various diseases. The company also produces and supplies active pharma ingredients, API raw products, API raw materials, and product materials.
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CD Bioparticles
Cholic Acid
Company Overview
CD Bioparticles, founded in Shirley, New York, is a manufacturer of biocompatible drug delivery systems. The company's product portfolio includes Liposomes, PEGylated liposomes, Polymer microspheres, Nanoparticles and Functional Biomedical Coatings. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. They also provide Contract services of drug delivery formulation developments, Product Selection Guidance, customer support, custom research projects and customized services.
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Central Drug House
Cholic Acid
Company Overview
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
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RXChemicals
Cholic Acid
Company Overview
RX Chemicals was founded in Mumbai, India, in 2011. RX Chemicals sells chemical-based products for many sectors including automobile, agriculture, airline, medicine, and accessories. Automobile products include carwash shampoo, compressor cleaner, and interior cleaners. Agricultural products include fungicides, herbicides, and pesticides. Airline products include exterior products such as deicing fluid, as well as interior products such as solvent cleaner. The company also provides a range of services including chemical inspection, logistics, chemical usage supervision, as well as tank cleaning.
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Cholic Acid Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Fengchen Group Co.,Ltd |
21.6%
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| 2 | Manus Aktteva Biopharma LLP |
17.6%
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| 3 | Cayman Chemical Company |
14.9%
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| 4 | Central Drug House |
9.5%
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| 5 | CD Bioparticles |
8.1%
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| 6 | Bacto Chem Laboratories |
6.8%
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| 7 | Angle Bio Pharma |
6.8%
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| 8 | Merck |
5.4%
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| 9 | Titan Biotech Limited |
4.1%
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| 10 | ICE S.p.a. |
2.7%
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Derivation Method
The ranking is calculated based on the click share within the cholic acid page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- Angle Bio Pharma: 2
Newly Established Company
- Angle Bio Pharma: 2017 (7 years ago)
- Fengchen Group Co.,Ltd: 2009 (15 years ago)
- Cayman Chemical Company: 1980 (44 years ago)
Company with a History
- ICE S.p.a.: 1949 (75 years ago)
- Bacto Chem Laboratories: 1972 (52 years ago)
- Cayman Chemical Company: 1980 (44 years ago)
Cholic Acid Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Cholic Acid Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
India
|
6 | 75.0% |
United States of America
|
1 | 12.5% |
Italy
|
1 | 12.5% |
