9 Guaiazulene Manufacturers in 2024
This section provides an overview for guaiazulene as well as their applications and principles. Also, please take a look at the list of 9 guaiazulene manufacturers and their company rankings. Here are the top-ranked guaiazulene companies as of April, 2024: 1.Zhengzhou Alfa Chemical Co.,Ltd.
Table of Contents
What Is Guaiazulene?
Guaiazulene is a hydrocarbon derivative of azulene, an organic compound. It is classified as a bicyclic sesquiterpene with the molecular formula C15H18. Guaiazulene has a molecular weight of 198.31, a density of 0.976 g/mL, a melting point of 31-33°C, and a boiling point of 153°C. It appears as a dark blue crystal or liquid at room temperature.
It is soluble in fats, oils, paraffin, waxes, and essential oils, and slightly soluble in anhydrous ethanol. Guaiazulene is insoluble in water but soluble in concentrated sulfuric acid and phosphoric acid. Due to its low melting point of around 31°C, careful storage consideration is necessary.
Uses of Guaiazulene
Guaiazulene is utilized as a coloring agent in cosmetics and as an anti-inflammatory in pharmaceuticals. Since guaiazulene is not water-soluble, it is often used in the form of a water-soluble derivative, sodium azulene sulfonate, which incorporates a sulfonic acid group.
In cosmetics, guaiazulene is found in milky lotions and cream-type products, helping to prevent acne and rough skin, and is also used in sunscreens.
In the pharmaceutical industry, guaiazulene is indicated for various conditions such as eczema, burns, pharyngitis, tonsillitis, stomatitis, acute gingivitis, glossitis, oral wounds, gastric ulcers, gastritis, and several eye conditions including conjunctivitis and keratitis.
Properties of Guaiazulene
1. Extraction and Synthesis of Guaiazulene
Naturally, guaiazulene can be extracted from the essential oil of plants like chamomile in the Hamamelidaceae family and is also a major pigment in some soft corals. Synthetically, it can be produced through dehydrogenative oxidation of sesquiterpene compounds such as guaiol, aromadendrene, and kessyl alcohol.
2. Mechanism of Action as a Pharmaceutical Product
Guaiazulenesulfonic acid, the pharmaceutical form of guaiazulene, inhibits leukocyte migration and histamine release from mast cells. Its action is thought to have a direct effect on inflammatory tissues without involving the pituitary-adrenal system.
Types of Guaiazulene
Guaiazulene is sold primarily as a reagent for research and as an industrial raw material. It is available in various capacities such as 10g, 25g, 100g, and 500g for research and development. In the chemical industry, it is supplied as a natural active ingredient in cosmetics and pharmaceuticals, typically in units of 1 kg or 25 kg, and transported in drums.
Pharmaceutical products containing guaiazulene include ointments, gargles, eye drops, topical applications, as well as tablets and granules for oral administration.
Other Information on Guaiazulene
Chemical Uses of Guaiazulene
In synthetic chemistry, guaiazulene serves as a base for various dye molecules and compounds. Examples include 3-(7-isopropyl-1,4-dimethylazulen-3-yl)-2-cyanoacrylic acid and 5-(7-isopropyl-1,4-dimethylazulen-3-yl)-2-cyanopenta-2,4-dienoic acid. It is also used in creating stilbazulenyl nitrones, a second-generation azulenyl nitrone functioning as a chain-breaking antioxidant, and in the synthesis of near-infrared fluorescence quenchers based on bis-azulenyl.
List of 9 Guaiazulene Manufacturers
*Including some distributors, etc.
Sort by Features
- Default
- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- China
- Japan
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Santa Cruz Biotechnology, Inc.
Guaiazulene
Company Overview
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
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Molekula Americas LLC
Guaiazulene
Company Overview
Molekula Group, established in 2000, is a chemical manufacturer and distributor based in Darlington, United Kingdom, supported by additional offices and warehouses in Germany, Italy, China, and the United States. The company operates two British subsidiaries, namely Scafell Organics Ltd, which manufactures fine organic chemicals, and Sherman Chemicals Ltd, which provides custom solutions across industries. The company adheres to ISO 9001:2015 standards and offers a diverse range of over 4,500 products. Their product portfolio includes analytical reagents, biochemicals, building blocks, organic and inorganic chemicals, as well as research organics and inorganics.
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KANTO CHEMICAL CO.,INC.
Guaiazulene
Manufacturer Overview
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
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Zhengzhou Alfa Chemical Co.,Ltd
Guaiazulene
Manufacturer Overview
Zhengzhou Alfa Chemical Co., Ltd. (ZACC) is a manufacturer of organic chemicals and catalysts established in 2010 and based in Jiaozuo, Henan. The company primarily produces pharmaceutical and organic intermediates as well as photoelectric materials for customers in life science, polymers, dyes, and metallurgy. The company's product lineup includes condensed ring compounds, heterocyclic compounds, COFS/MOFS, and metal catalysts. These supply client corporations such as Bayer AG, Pfizer Inc., and Sumitomo Chemical Company, Ltd. ZACC also offers gram- to ton-level contract synthesis and production services.
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Hefei TNJ Chemical Industry Co.,Ltd.
Guaiazulene
Manufacturer Overview
Hefei TNJ Chemical Industry Co., Ltd, established in 2001, is headquartered in China. The company is a chemical manufacturer and supplier of chemicals to domestic Chinese and global consumers in four primary markets: chemicals, food, pharmaceuticals, and personal care. Chemicals include fine chemicals, agrochemicals, and other chemicals. Food includes agrochemicals, vitamins, amino acids, and food ingredients. Pharmaceuticals include specific chemicals such as Povidone iodine, Clotrimazole crystalline, and Lincomycin. The company also features a CAS databank for CAS-registered chemical compounds.
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MilliporeSigma
Guaiazulene
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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Shandong Chuangying
Guaiazulene
Manufacturer Overview
Shandong Chuangying, established in 2005 and based in China, is a manufacturer of chemicals. The company produces products such as disinfectant and antiseptic series, daily chemicals, cosmetic raw materials, food/feed additives, and catalysts & chemical auxiliary agents and supplies to different industries such as agriculture, cosmetics, industrial, pharmaceutical, and chemical. All these products are exported to different countries such as Asia, Southeast Asia, Europe, and America. The product line is produced according to the ISO9001, ISO14001, and GB/T-28001 requirements, and the company holds ISO-9001, CE, and SGS certifications.
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Guaiazulene Manufacturer Ranking
*Including some distributors, etc.Ranking as of April 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Molekula Americas LLC |
44.4%
|
| 2 | MilliporeSigma |
44.4%
|
| 3 | Zhengzhou Alfa Chemical Co.,Ltd |
11.1%
|
Derivation Method
The ranking is calculated based on the click share within the guaiazulene page as of April 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- KANTO CHEMICAL CO.,INC.: 1,062
- Hefei TNJ Chemical Industry Co.,Ltd.: 210
Newly Established Company
- Suzhou Bowa Sunshine Co.,Ltd.: 2016 (8 years ago)
- Xi'an PINO Biotech Co., Ltd.: 2006 (18 years ago)
- Hefei TNJ Chemical Industry Co.,Ltd.: 2001 (23 years ago)
Company with a History
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- Hefei TNJ Chemical Industry Co.,Ltd.: 2001 (23 years ago)
- Xi'an PINO Biotech Co., Ltd.: 2006 (18 years ago)
Guaiazulene Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Guaiazulene Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
China
|
4 | 57.1% |
United States of America
|
2 | 28.6% |
Japan
|
1 | 14.3% |
