14 Crotonic Acid Manufacturers in 2024
This section provides an overview for crotonic acid as well as their applications and principles. Also, please take a look at the list of 14 crotonic acid manufacturers and their company rankings. Here are the top-ranked crotonic acid companies as of November, 2024: 1.Manus Aktteva Biopharma LLP, 2.BioCrick, 3.MUBY CHEMICALS.
Table of Contents
What Is Crotonic Acid?
Crotonic acid is an organic compound classified as a monounsaturated fatty acid.
Its molecular formula is C4H6O2, and it has one double bond in the molecule; its IUPAC nomenclature is (E)-but-2-enoic acid, and its CAS number is 107-93-7.
It is found in nature as the main component of hazel oil, and the name crotonic acid is also derived from the genus hazel. It has a molecular weight of 86.09, a melting point of 70-73°C, and a boiling point of 185-189°C. It is a white to yellow needle-like crystalline solid at room temperature.
It has a pungent odor similar to butyric acid. It has an acid dissociation constant pKa of 4.69 and a density of 1.02 g/cm3. The substance is soluble in a variety of organic solvents, including water, ethanol, and acetone.
Uses of Crotonic Acid
The main use of crotonic acid is as a raw material for copolymers, which is formed by copolymerization with other substances. Major copolymerization monomers include vinyl compounds, such as vinyl acetate. Synthesized copolymer compounds are used as film formers, adhesives, and hair styling agents.
Crotonic acid is also used in the copolymerization of crotonic acid hydrogel systems using gamma radiation. The cross-linked copolymer crotonic acid hydrogel is a substance that has been shown to be effective in slow-release fertilizers and drugs and in preventing environmental pollution.
Other applications include use as a raw material for various organic syntheses such as pharmaceuticals, fragrances, and agrochemicals.
Characteristics of Crotonic Acid
The double bond of crotonic acid has a trans structure. Crotonic acid has a geometric isomer with a cis double bond, called isocrotonic acid.
Isocrotonic acid is an isolable stable oily liquid with a boiling point of 171.9°C. It is isomerized to crotonic acid by the action of heat, light, or acid. Crotonic acid is a substance that may polymerize or be altered by the action of light or peroxides. It is advisable to store it in light-shielded containers.
Its flash point is 87.8℃ and its spontaneous combustion temperature is 396℃.
Types of Crotonic Acid
Crotonic acid is mainly sold as a reagent for synthetic organic chemical applications. The product is available in 25g, 500g, 3kg, and other capacities that are easy to handle in the laboratory. The reagent product can be stored at room temperature.
Other Information on Crotonic Acid
1. Synthesis of Crotonic Acid
Crotonic acid is industrially synthesized by the oxidation of crotonaldehyde. Other synthetic methods include the condensation reaction of acetaldehyde and malonic acid in the presence of a base.
2. Chemical Reaction of Crotonic Acid
Crotonic acid reacts with N-ethyl-o-toluidine as a raw material for crotonamidone. It is also a substance that undergoes a copolymerization reaction when reacted with vinyl compounds.
Other examples of chemical reactions include:
- Reduction of double bonds with zinc/sulfuric acid
- Addition reactions to double bonds with chlorine or bromine
- Formation reaction of 3-bromobutyric acid with hydrogen bromide
- Addition of hydroxyl groups under alkaline conditions with potassium permanganate
- Formation reaction of acid anhydride by heating with acetic anhydride, etc.
- Esterification reaction by reaction of alcohol and sulfuric acid
In addition, reaction to hypochlorous acid produces 2-chloro-3-hydroxybutyric acid. This substance is used in various reactions, such as butyric acid formation (reduction reaction) by sodium amalgam, dehydration reaction (double bond formation) by sulfuric acid, and epoxidation reaction by potassium ethoxide.
Crotonic acid poses a fire and explosion hazard when reacting violently with bases, oxidizing agents, and reducing agents. Although stable under normal storage conditions, it should not be mixed with bases, oxidizing agents, or reducing agents.
List of 14 Crotonic Acid Manufacturers
*Including some distributors, etc.
Sort by Features
- Default
- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- India
- Japan
- United Kingdom
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Wego Chemical Group Inc
Crotonic Acid
Distributor Overview
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
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Parchem
Crotonic Acid
Distributor Overview
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
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KANTO CHEMICAL CO.,INC.
Crotonic acid
Manufacturer Overview
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
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Manus Aktteva Biopharma LLP
Crotonic Acid
Manufacturer Overview
Manus Aktteva Biopharma LLP, established in 2010 and headquartered in Ahmedabad, India, is a manufacturer, supplier, and exporter of pharmaceutical APIs, intermediates, and specialty chemicals. Their wide-ranging products cater to industries such as pharmaceutical, nutraceutical, and biotechnology. They offer Active Pharmaceutical Ingredients (APIs), the fundamental components used in various drug formulations, such as antibiotics, cardiovascular drugs, and anti-inflammatory drugs. The company also supplies specialty chemicals with unique properties applicable to diverse industries, from plastics to cosmetics manufacturing. Furthermore, the company offers custom synthesis services to meet the specific needs of their customers.
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Alpha Chemica
Crotonic Acid
Manufacturer Overview
ALPHA CHEMICA, established in 1985, is an Indian manufacturer and supplier of laboratory reagents and fine chemicals, headquartered in Mumbai, Maharashtra. Their wide range of products includes high-performance liquid chromatography (HPLC), analytical reagent/guaranteed reagent (AR/GR), laboratory reagents (LRs), and fine chemicals, catering to life science and other specialty research. During the COVID-19 pandemic and its aftermath, ALPHA CHEMICA offered BactGO, a disinfectant solution with stabilized hydrogen peroxide using silver-based chemistry, and BaVi-X, a 75% alcohol-based hand sanitizer.
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MUBY CHEMICALS
Crotonic Acid
Manufacturer Overview
MUBY CHEMICALS, established in 1976, is a manufacturer and supplier of chemicals and excipients used in pharmaceuticals, cosmetics & personal care, agrochemical, and textile industries. Based in Ankleshwar, Gujarat, India, the company offers Shale gas hydraulic Fracturing Chemicals such as ammonium persulfate, diverting agents, inhibitors, ATMP phosphonate, and encapsulated gel breakers. Some food analytical reagent chemicals include benzyl alcohol, calcium oxide, boric acid, carbamide peroxide, and lithium carbonate. The company is GLP-approved, Kosher Certified, "REACH" Registered, and ISO-9001 Certified.
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Merck
Crotonic acid
Manufacturer Overview
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
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MilliporeSigma
Crotonic Acid
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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Central Drug House
Crotonic Acid
Company Overview
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
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SRL
Crotonic Acid
Company Overview
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
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BioCrick
Crotonic Acid
Company Overview
BioCrick Co., Ltd is located in Chengdu Tianfu Life Science Park in Sichuan Province, China. The company creates a natural product library which provides small molecular compounds with potential biological and pharmacological activities for pharmaceutical, agricultural, and biotechnology companies worldwide. The company’s database includes more than 8,000 compounds collected from natural sources such as as medicinal plants, herbs, fungus, and microbes. The company also a provider of peptides and lab reagents for biological research, carrying a product line in apoptosis, epigenetic, and cancer biology.
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Otto Chemie Pvt. Ltd
Crotonic Acid
Distributor Overview
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
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Glentham Life Sciences Limited
Crotonic Acid
Distributor Overview
Glentham Life Sciences is based in Corsham, United Kingdom. Glentham Life Sciences is a leading supplier of fine chemicals, raw materials, reagents, and life science products. Glenthem also offers a number of services including custom packaging, call-off orders, and safety documentation. Glentham’s product offerings include chemicals such as amino acids, antibiotics, APIs, biochemicals, buffers, carbohydrates, chitin, chitosan, detergents, dyes, stains, enzymes, inorganic, peptide reagents, phytochemical, raw materials, solvents, steroids, and vitamins among others.
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Tocris Bioscience
Crotonic Acid
Distributor Overview
Tocris Bioscience, trading as Tocris Cookson Ltd., established in 1982 and headquartered in Bristol, UK, is a supplier of life science reagents. Its extensive product range encompasses receptor agonists and antagonists, enzyme inhibitors, ion channel modulators, fluorescent probes and dyes, along with PROTAC Degraders for targeted protein degradation. The compay has received several accolades, including The Queen's Awards for Enterprise in International Trade. The company is part of the life science division of Bio-Techne, which also includes class brands R&D Systems, Novus Biologicals, ProteinSimple and Advanced Cell Diagnostics.
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Crotonic Acid Manufacturer Ranking
*Including some distributors, etc.Ranking as of November 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Manus Aktteva Biopharma LLP |
17.6%
|
| 2 | BioCrick |
17.6%
|
| 3 | MUBY CHEMICALS |
17.6%
|
| 4 | Alpha Chemica |
11.8%
|
| 5 | KANTO CHEMICAL CO.,INC. |
11.8%
|
| 6 | SRL |
5.9%
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| 7 | Parchem |
5.9%
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| 8 | MilliporeSigma |
5.9%
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| 9 | Merck |
5.9%
|
Derivation Method
The ranking is calculated based on the click share within the crotonic acid page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
- KANTO CHEMICAL CO.,INC.: 1,062
Newly Established Company
- Parchem: 1999 (25 years ago)
- Tocris Bioscience: 1982 (42 years ago)
- Wego Chemical Group Inc: 1978 (46 years ago)
Company with a History
- KANTO CHEMICAL CO.,INC.: 1944 (80 years ago)
- SRL: 1975 (49 years ago)
- MUBY CHEMICALS: 1976 (48 years ago)
Crotonic Acid Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Crotonic Acid Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
India
|
6 | 60.0% |
United States of America
|
2 | 20.0% |
Japan
|
1 | 10.0% |
United Kingdom
|
1 | 10.0% |
