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This section provides an overview for quinidine as well as their applications and principles. Also, please take a look at the list of 3 quinidine manufacturers and their company rankings. Here are the top-ranked quinidine companies as of December, 2024: 1.Taj Pharmaceuticals Limited, 2.MilliporeSigma, 3.KANTO CHEMICAL CO.,INC..
Table of Contents
Quinidine is a white crystalline powder alkaloid. Its IUPAC name is (S)-(6-Methoxyquinolin-4-yl)[(1S,2R,4S,5R)-5-vinylquinuclidin-2-yl]methanol. It is also known as conquinine, among other names.
The chemical formula of quinidine is C20H24N2O2 and its molecular weight is 324.42. Its CAS number is 56-54-2.
Quinidine is an alkaloid extracted from the bark of the genus cinchona.
Because of its potent anti-arrhythmic action, quinidine has long been used in the pharmaceutical field as a treatment for atrial and ventricular arrhythmias. In the myocardium, it attenuates excitability by inhibiting the flow of sodium and potassium across the cell membrane. This attenuating effect on excitability results in the suppression of irregular contractions of the myocardium.
By binding to heme polymer in the acid-fed vacuole of the parasite and inhibiting polymerization by heme polymerase enzyme, it exerts its antimalarial activity mainly by acting as an intraerythrocytic mitotic agent. However, it is not used as a first-line drug when administered alone, but in combination with doxycycline or with other drugs.
It is contraindicated and therefore not available for use in patients with stimulated conduction defects, severe congestive heart failure, or symptoms of hyperkalemia. A number of other concomitant medications have been reported to be prohibited.
Quinidine derivatives are used as ligands for the sharpless asymmetric dihydroxylation reagent AD-mix-β.
Quinidine has a melting point of 174°C and is solid at room temperature. It is very soluble in methanol, soluble in alcohol, ether, and chloroform, and insoluble in petroleum ether.
The acid dissociation constant (pKa), one of the quantitative indicators of acid strength, is 8.56. A smaller pKa indicates a stronger acid.
Most of the quinidines currently on the market are produced by isomerization of quinine. From natural sources, quinidine is obtained from the mother liquor that remains after the quinine has been removed from an extract of the genus cinnamomum. It can be purified by recrystallization in water or alcohol.
Handling
Avoid contact with strong oxidizers. Use in a draft chamber with local exhaust ventilation and wear personal protective equipment.
In case of fire
Quinidine is nonflammable and will not itself burn. However, thermal decomposition may produce nitrogen oxide gas. Use water spray, foam, powder extinguisher, carbon dioxide, dry sand, etc. to extinguish fire.
If adhered to skin
Care should be taken to prevent adhesion to skin. Always wear protective clothing such as a lab coat or work clothes and protective gloves when using the product. Never roll up the sleeves of protective clothing to avoid skin exposure.
In the event of skin contact, it is important to wash off with soap and plenty of water. If on clothing, remove all contaminated clothing and isolate. If symptoms persist, medical attention is required.
In case of eye contact
Always wear protective glasses or goggles when using the product. In the unlikely event of eye contact, rinse carefully with water for several minutes. If wearing contacts, remove them if they can be easily removed and rinse thoroughly. Immediate medical attention is required.
Storage
Store in a tightly closed, light-shielded glass container. A well-ventilated, cool place, away from direct sunlight, is desirable.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Taj Pharmaceuticals Limited, established in 1995 and headquartered in Mumbai, India, is a global manufacturer and supplier of generic medicines, healthcare, and other products. The company markets more than 500 branded and 4600 generic compositions to consumers in over 40 countries and territories across the globe. Its products cover a vast array of therapeutic categories, and offers an extensive range of dosage forms and delivery systems including oral solids, controlled-release, and steriles. Some of its offerings are diabetic care products, insulin, and growth hormones. The company holds the ISO 9001:2000 certification for its quality management system.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Taj Pharmaceuticals Limited |
33.3%
|
| 2 | MilliporeSigma |
33.3%
|
| 3 | KANTO CHEMICAL CO.,INC. |
33.3%
|
Derivation Method
The ranking is calculated based on the click share within the quinidine page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
1 | 50.0% |
|
India
|
1 | 50.0% |
