7 Quinine Manufacturers in 2024
This section provides an overview for quinine as well as their applications and principles. Also, please take a look at the list of 7 quinine manufacturers and their company rankings. Here are the top-ranked quinine companies as of April, 2024: 1.Merck, 2.electronic medicines compendium, 3.SAE Manufacturing Specialties Corp.
Table of Contents
What Is Quinine?
Quinine (chemical formula C20H24N2O2) is an alkaloid found in the bark of the cinchona tree, which is a tree native to Peru.
An alkaloid is a general term for basic, naturally occurring plant constituents that contain at least one nitrogen atom. Quinine is a diastereoisomer of quinidine.
It is an alkaloid that has been used as an antimalarial drug used since the 1600s. It is also effective in the treatment of filariasis and babesiosis. It has also long been used in the tropics to disinfect drinking water and to remove blue-green algae from drinking water.
Quinine has a bitter taste and fluoresces under ultraviolet light. It should be stored in a dark room because it reacts easily to light. The extracted compound exists as a white crystalline powder at room temperature.
Uses of Quinine
Quinine is used primarily as an antimalarial agent. Malaria is an infectious disease caused by a parasite of the genus Plasmodium called Plasmodium falciparum, which is transmitted to humans via mosquitoes.
Quinine is toxic to Plasmodium falciparum, and it prevents it from lysing red blood cells, thereby alleviating symptoms. It is also used to treat filariasis and babesiosis. It has antipyretic and analgesic properties and a direct effect on muscle membranes, and is often used in the pharmaceutical field as a remedy for common colds, nocturnal leg cramps, and myotonic disorders.
Quinine is also used as a bittering and flavoring agent due to its extremely bitter taste, for example, in the production of tonic water. The addition of quinine to drinking water has the effect of preventing the growth of microorganisms in addition to its palatability.
Disinfection of drinking water in tropical areas and removal of blue-green algae are also among its uses.
Properties of Quinine
Quinine is an alkaloid extracted from the bark of the cinchona tree, a member of the Rubiaceae family of plants.
It is a compound with molecular formula C20H24N2O2 and molecular weight 324.43 g/mol, and is a type of quinoline, a basic cyclic molecule. The structure of quinine is closely related to its bioactivity.
Based on the structure of quinine, artificial antimalarials such as chloroquine and mefloquine were later developed.
Quinine and other cinnamic alkaloids can be used as catalysts for stereoselective reactions in organic synthesis. It is also used as a fluorescent standard in photochemistry because of its constant fluorescence wavelength and high fluorescence quantum yield.
Its absorption wavelength peaks at around 350 nm and its fluorescence wavelength peaks at around 460 nm. The fluorescence at this time shows a bright blue color. Its fluorescence quantum yield is high in acidic solutions, and it shows high fluorescence of φ=0.58 in 0.1M sulfuric acid solution.
Other Information on Quinine
How Quinine Is Produced
Quinine is extracted from the bark of the cinchona tree, a natural product. There have been several reports on the production of quinine by chemical synthesis, but all of them are complicated processes and are inferior to isolation from natural resources in terms of economics.
In addition, the advantages of chemical synthesis of quinine for the treatment of malaria have been lost with the development of synthetic drugs (chloroquine, mefloquine, haloquine, etc.), which have a higher safety margin and can be mass-produced.
The extraction process from the plant is as follows:
- The bark from a tree of the genus Cinchona is collected.
- The bark is dried and crushed to a fine powder.
- The bark is soaked in water or alcohol to extract quinine.
- The extract is filtered and concentrated.
- The concentrated liquid is chromatographed to purify the quinine.
List of 7 Quinine Manufacturers
*Including some distributors, etc.
Sort by Features
- Default
- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- Japan
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SAE Manufacturing Specialties Corp
Quinine
Manufacturer Overview
Based in Bayville, NY, SAE Manufacturing Specialties Corp. is an ISO-certified supplier and manufacturer of industrial equipment, chemicals, components, ordinance, electronics, and systems for industries ranging from aerospace to high tech to law enforcement. Examples of product offerings include raw materials, chemicals, and lubricants for industrial purposes to finished products such as security helmets for law enforcement, and military ordnances. SAE also provides research and development as well as technical support for other companies in similar industries.
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Merck
- -Quinine
Manufacturer Overview
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
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MilliporeSigma
Quinine
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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electronic medicines compendium
Quinine Bisulphate Tablets 300mg
Manufacturer Overview
Hope Pharmaceuticals Ltd, established in 1990 and headquartered in Scottsdale, Arizona, USA, is a manufacturer and supplier of various pharmaceutical products. Its product range includes injectable drugs, topical drugs, and ophthalmic drugs. Some of the products that the company offers include Sodium Thiosulfate Injection, Sodium Nitrite Injection, Sodium Bicarbonate Injection, as well as Sodium Acetate Injection, and Potassium Phosphate Injection. Its products are used for the treatment of various medical conditions.
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nacalai
Quinine
Company Overview
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
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The United States Pharmacopeial Convention
Quinine
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ChemPoint
Quinine
Distributor Overview
ChemPoint, established in 1999 and a subsidiary of Univar Solutions Inc., is a fine and specialty chemical distributor headquartered in Bellevue, Washington. The company runs ChemPoint, a personalized e-distribution platform that enables the marketing and sales of specialty and fine chemicals in North America, Europe, the Middle East, and Africa. The platform features MarketConnect, a web-based tool that offers market transparency to customers and allows producers to review sales processes. ChemPoint offers a diverse range of specialty chemical products, including adhesives, lubricating fluids, polymers, sealants, and thermoplastics.
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Quinine Manufacturer Ranking
*Including some distributors, etc.Ranking as of April 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Merck |
29.4%
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| 2 | electronic medicines compendium |
17.6%
|
| 3 | SAE Manufacturing Specialties Corp |
17.6%
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| 4 | MilliporeSigma |
11.8%
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| 5 | nacalai |
11.8%
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| 6 | The United States Pharmacopeial Convention |
5.9%
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| 7 | ChemPoint |
5.9%
|
Derivation Method
The ranking is calculated based on the click share within the quinine page as of April 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
- nacalai: 1934 (90 years ago)
- The United States Pharmacopeial Convention: 1820 (204 years ago)
Company with a History
- The United States Pharmacopeial Convention: 1820 (204 years ago)
- nacalai: 1934 (90 years ago)
Quinine Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Quinine Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
United States of America
|
1 | 50.0% |
Japan
|
1 | 50.0% |
