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This section provides an overview for ethylene diamine tetraacetic acid as well as their applications and principles. Also, please take a look at the list of 20 ethylene diamine tetraacetic acid manufacturers and their company rankings. Here are the top-ranked ethylene diamine tetraacetic acid companies as of April, 2025: 1.Junsei Chemical Co.,Ltd., 2.Cepham Life Sciences, 3.KANTO CHEMICAL CO.,INC..
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Ethylenediaminetetraacetic Acid (chemical formula C10H16N2O8) is a type of metal chelating agent that exists as a colorless crystalline individual at room temperature. It is also known as EDTA, or edetic acid.
It sequesters metal ions, thus preventing their inherent reactions with other components and creating stable water-soluble chelates.
Ethylenediaminetetraacetic Acid is mainly used as a chelating agent in a variety of fields.
Ethylenediaminetetraacetic Acid is used to measure the concentration of metal ions by utilizing its 1:1 bonding property with metal ions.
First, an indicator that develops color by forming a complex with a metal ion is added to a metal ion solution of unknown concentration.
Next, an aqueous solution of EDTA, the concentration of which is known, is gradually added drop by drop.
When all the metal ions in the solution form chelate complexes, the coloration disappears. The concentration of the metal ions is determined from the amount of EDTA solution dropped at this time.
Ethylenediaminetetraacetic Acid is used in the treatment of tap water to remove calcium and magnesium salts that have accumulated in the pipes. It is also used in the food and cosmetics industries to prevent poor quality caused by metal ions.
In the pharmaceutical field, it is used to maintain the properties of drugs that prevent blood clotting, antibiotics, antihistamines, and local anesthetics.
Ethylenediaminetetraacetic Acid is also sometimes used in the treatment of heavy metal poisoning, known as chelation therapy. Metal poisoning is a condition caused by the accumulation of excess metal ions in the body. It is administered to remove excess metal ions from the body, thereby relieving the symptoms of poisoning. For example, it is used to treat patients with lead poisoning.
Cells, proteins, and DNA are bound together via metal ions, and EDTA is used to diverge these bonds.
For example, artificially cultured cells are bound to each other via metal ions, and an enzyme solution with EDTA is commonly used to break cells apart from each other. DNA and proteins are also often bound to metal ions, which can be removed by adding EDTA.
Oxidation is known to occur in rubber, vegetable oils, and foods through the catalytic action of trace amounts of metal ions. Since oxidation causes quality deterioration, ethylenediaminetetraacetic acid is sometimes added as an antioxidant as a countermeasure.
Ethylenediaminetetraacetic Acid is a white solid at room temperature with a molecular weight of 292.24 and a melting point of 237-245℃. Its solubility in water is 0.2g/100g and octanol/water partition coefficient is -3.86.
Ethylenediaminetetraacetic Acid has the property of binding to and forming complexes with metal ions that affect products. Since it traps metal ions, it acts to prevent inherent reactions between metal ions and other components.
The binding of a ligand with multiple coordination sites to a metal ion is called a chelate, and EDTA is known to form stable, water-soluble chelates with many metal ions.
Ethylenediaminetetraacetic Acid has four coordination loci, allowing it to bind to almost any metal ion from 1 to 4 valence, including silver, calcium, copper, and iron.
Ethylenediaminetetraacetic Acid is produced by reacting ethylenediamine, sodium cyanide, and formalin in the presence of an alkali at 60 to 150°C. The resulting solution in the sodium salt state is then used to produce EDTA.
Ethylenediaminetetraacetic Acid in the sodium salt state obtained can be purified to obtain highly pure EDTA. Ethylenediaminetetraacetic Acid is usually sold as the divalent sodium salt.
Ethylenediaminetetraacetic Acid can have a negative impact on the environment. It is highly water soluble, and if released into wastewater, it can enter rivers, oceans, and other bodies of water.
If wastewater containing EDTA is not properly treated, it may adversely affect aquatic life and water quality by binding dissolved metal ions in the water.
Ethylenediaminetetraacetic Acid binds strongly to metal ions and has been reported to cause adverse effects such as bone marrow suppression and renal failure when ingested in large quantities. However, it is safe in commonly used concentration ranges and may be added to foods and pharmaceuticals.
*Including some distributors, etc.
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Cepham Life Sciences, founded in 2013, and located in Fulton, Maryland, is a manufacturer of life science research products. The company offers a diverse range of bioscience research products including assay kits, ELISA kits, antibodies, recombinant proteins, and enzymes. They specialize in products for areas like Cell Metabolism, Proliferation, Stress, Damage, and Repair. Its portfolio also includes biochemicals, buffers, reagents, catering to academic research, drug discovery, and clinical labs. Stringent quality control is conducted at their advanced facilities in Maryland and New Jersey, USA.
ProChem, Inc was founded in 9186 and is headquartered in Rockford, Illinois. The company is a manufacturer of high-purity inorganic chemicals and materials including rare earth, sputtering targets, and organometallic compounds. The company serves numerous industries including research and manufacturing and has collaborated with such organizations as Lawrence Livermore National Laboratory. The company offers custom synthesis of advanced materials, product-specific packaging, purification services, and costume blending and tooling of chemical compounds.
Kind Chemical was established in 2019 in The Woodlands, Texas, US, as a global chemical trading company. Their product range comprises 2-ethylhexyl acetate, benzyl alcohol, acetophenone extra, acrylic acid, terpenes, mint oil, Ionone 100%, acetic acid, and basil oil, among others. The chemicals offered have broad applications: as solvents in coatings, preservatives in cosmetics, intermediates in pharmaceuticals, ingredients in adhesives, and components in aromatherapy and flavors. The company caters to the mining, agriculture, flavor and fragrance, personal care, pharmaceutical, CASE, and Oil and Gas industries.
E & C Chemicals Inc., founded in 1993, is an American manufacturer based in Carrollton, Georgia, specializing in chemical blending of liquid and dry products. The company's facility is equipped with blending tanks, ranging from 100 to 10,000 gallons in capacity, alongside ribbon blenders, suitable for both small and large batch custom dry material production. This enables the packaging of finished products into drums, bags, super sacks, and multi-compartment tank trucks. Some of the company’s products include aluminum sulfate, calcium chloride, urea, and aluminum sulfate. These diverse offerings cater to various industries, including agriculture, food and beverages, chemicals, sanitation, and water treatment.
PhytoTech Labs, founded in 1997, is a manufacturer and distributor of plant research and laboratory products. The company is located in Lenexa, Kansas, and runs a European Union distribution center. They mainly supply kits, reagents, and equipment to those who deal with plant biotechnology, tissue culture, and science. They also distribute to firms involved with molecular biology, plant pathology, and defense. Additionally, they custom-manufacture several media like a woody plant, seed testing, and orchid, for clients to aid in their production and research.
ChemCeed, founded in 2009 and headquartered in Chippewa Falls, Wisconsin, is a worldwide chemical supplier that is ISO 9001 certified. It provides chemicals like base oils, corrosion inhibitors, and specialty esters used in several industries, including construction, paper manufacturing, and water treatment. It also provides a broad selection of support services, including labeling, repackaging, and logistical support. The company stocks its products in several locations around the United States, including Chicago (IL), Philadelphia (PA, and Piscataway (NJ). In 2016, it received WBE certification and was NACD verified in 2023.
Wego Chemical Group was founded in 1978 and headquartered in Great Neck, New York. WEGO is a full-service supplier and distributor of chemicals, minerals, and other raw materials to clients around the world. Markets and segments include agriculture & animal care, chemical & material manufacturing, construction & building materials, electronics, food & beverage, “household, industrial & institutional”, mining, oil & gas, personal care & pharmaceutical, paper & packaging, surface treatment, textiles, and water treatment.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
Mitsubishi Chemical Corporation was founded in 1933 and has a head office in Tokyo, Japan. Mitsubishi Chemical Corporation provides products including chemicals, industrial gases, and health care products to customers globally. Mitsubishi Chemical Group’s performance products division manufactures and distributes. functional food materials, electronic and electrical components, specialty chemicals, and other products. Mitsubishi Chemical health care products include pharmaceuticals, drug discovery solutions, diagnostic reagents, and instruments for medical use. Mitsubishi Chemical Corporation also provides other services such as engineering, information systems, logistics, and consulting.
Toronto Research Chemicals Inc., founded in 1982 and based in Toronto, Canada, is a manufacturer of biochemicals and is a subsidiary of LGC Standards. The ISO 9001-certified company has an extensive catalog of over 350,000 products, including metabolites, impurities, and natural products APIs, which are used in several applications like environmental analysis, forensic science, and medicinal R&D. The company supports the scientific community across more than 120 countries and has 19 production laboratories. In 2019, it was bought by LGC, which provides components to customers in the pharmaceutical, clinical diagnostics, and food markets, among others.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
GFS Chemicals was founded in 1928 and is based in Columbus, Ohio. GFS Chemicals is an ISO 9001:2015 certified manufacturer as well as a supplier of specialty and fine chemicals, serving customers worldwide. GFS serves an array of industries including pharmaceutical, electronics, energy, fragrances, agrichemical, and specialty polymers. GFS Chemicals supplies over 8,600 chemicals in the United States, available in both small and large quantities. GFS Chemicals also offers Karl Fischer reagents, PPT/PPB trace analysis grade acids, turbidity standards, and other high-quality materials.
North Metal & Chemical Co. was established in 1921 and specializes in the production of tungsten, molybdenum compounds, and other rare earth elements, and its headquarters are located in York, United Kingdom. The company manufactures sodium molybdate and various other chemicals, operating under the ownership and management of a fourth-generation family. The company offers molybdenum, tungsten compounds, and various chemicals to cater to the needs of industries involved in water treatment, pigment production, agriculture, metal finishing, and other products. The organization provides sodium molybdate and various other chemical substances.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Ebrator Biochemicals, Inc. is a manufacturer and supplier of fine chemicals and life science materials for use in the pharmaceuticals, biotech, and healthcare industries. Founded in 2018 and based in Santa Ana, California, the company provides various biological stains and dyes, analytical agents, impurities, and DNA cloning materials for applications in diagnostics and scientific research. The company’s specialized product range includes amino acids and carbohydrates, ACS reagents, plasmids and restriction enzymes. Ebrator Biochemicals, Inc. also offers custom synthesis and packaging services for its clients, which include Quest Diagnostic, Pfizer, and Thermo Fisher Scientific.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Connect Chemicals USA, LLC is a producer, custom manufacturer and distributor of specialty chemicals that was established in 1998 and is headquartered in Ratingen, Germany. The company has a US subsidiary that is based in Houston, Texas. The company’s products include a wide range of specialty chemicals, including solvents, adhesives, coatings, and lubricants. Its products are used by several industries, as diverse as cosmetics, pharmaceuticals, and food and beverage. The company also offers a wide range of services, including custom manufacturing, formulation, and packaging.
Reagents, established in 1997 and headquartered in New York, USA, is a manufacturer and distributor of laboratory chemicals and reagents. Serving academic institutions, research laboratories, pharmaceutical companies, and other industries, the company offers a diverse range of products that encompass organic and inorganic chemicals used in pharmaceuticals, plastics, water treatment, and more. They provide biological stains and indicators for laboratory applications like cell culture and DNA analysis, along with culture media ingredients for microbial growth. Their product portfolio also caters to applications in batteries, pigments, and catalysts. Reagents' comprehensive offerings support education, research, and manufacturing processes across various sectors.
Ranking as of April 2025
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Junsei Chemical Co.,Ltd. |
11.1%
|
| 2 | Cepham Life Sciences |
10.3%
|
| 3 | KANTO CHEMICAL CO.,INC. |
7.7%
|
| 4 | ProChem, Inc. |
6.8%
|
| 5 | PhytoTech Labs |
6.0%
|
| 6 | Toronto Research Chemicals |
5.1%
|
| 7 | Kind Chemical |
5.1%
|
| 8 | E & C Chemicals Inc. |
5.1%
|
| 9 | Ebrator Biochemicals Inc. |
5.1%
|
| 10 | MilliporeSigma |
5.1%
|
Derivation Method
The ranking is calculated based on the click share within the ethylene diamine tetraacetic acid page as of April 2025. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
7 | 50.0% |
|
Japan
|
5 | 35.7% |
|
Canada
|
1 | 7.1% |
|
Switzerland
|
1 | 7.1% |
3 products found
3 products
Yagyu Shokai Co., Ltd.
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■Features ・A reagent suitable for detaching and dispersing human iPS/ES cells. ・Contains no animal-derived components, and can adjust the dispers...
Yagyu Shokai Co., Ltd.
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It is prepared in advance to the specified concentration.
Laiki Co., Ltd.
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Ethylenediaminetetraacetic acid
