This section provides an overview for azobisisobutyronitrile as well as their applications and principles. Also, please take a look at the list of 13 azobisisobutyronitrile manufacturers and their company rankings. Here are the top-ranked azobisisobutyronitrile companies as of November, 2024: 1.Paras Polymer & Chemicals, 2.Allychem Co., Ltd., 3.Ester India.
Table of Contents
Azobisisobutyronitrile, commonly abbreviated as AIBN and also known as α,α'-azobisisobutyronitrile, is an organic compound widely used as a reagent. In IUPAC nomenclature, it is designated as "2,2'-(diazene-1,2-diyl) bis (2-methyl-propane nitrile)," with the CAS registration number 78-67-1. It is an azo compound with a cyano group, a colorless solid at room temperature, and has a molecular formula of C8H12N4 and a molecular weight of 164.21.
Azobisisobutyronitrile is soluble in organic solvents like ether and alcohols, but nearly insoluble in water.
This compound decomposes easily, releasing 2-cyano-2-propyl radical along with nitrogen gas, a property widely utilized as a radical initiator in various radical reactions. It's used in polymerization reactions for synthesizing vinyl compounds and polystyrene, hydrobromination of alkenes using hydrogen bromide (HBr), and as an intermediate in organic synthesis and a foaming agent in rubber and plastics.
The principle of Azobisisobutyronitrile lies in its chemical properties and reactions. It decomposes under heat or light, forming nitrogen gas and 2-cyano-2-propyl radicals, which recombine to produce 2,2,3,3-tetramethylsuccinodinitrile in the absence of other reactants. This decomposition is facilitated by the electron-withdrawing effect of the adjacent cyano group and the energetic favorability of nitrogen gas formation.
The radicals generated are ideal as initiators for various radical reactions, with thermal decomposition typically occurring at 95-104°C. However, caution is needed as it can explode in acetone solutions and must be stored in a cool, dark, and light-shielded place.
As a radical initiator, AIBN is involved in reactions like the generation of tributyltin radical and the Wohl-Ziegler bromination reaction. In the former, AIBN-derived radicals draw hydrogen from tributyltin to form tin radicals for reduction reactions. In the latter, AIBN is used with N-bromosuccinimide (NBS) to brominate alkenes and aromatic compounds.
Azobisisobutyronitrile is available in two types: industrial grade for resin synthesis and laboratory reagents. Industrial products are typically used in large volumes in factories, whereas laboratory reagents are available in smaller quantities like 25g, 500g, and 12wt.% acetone solutions. Due to its degradability, it must be stored properly, and care should be taken to handle the internal pressure caused by generated nitrogen gas when opening the bottle.
*Including some distributors, etc.
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Japan Finechem Co.,Inc. manufactures fine and speciality chemicals and industrial electronic components. The company was founded in Tokyo, Japan in 1959 and presently employs 272 employees overall Japan. Their product portfolio for chemicals includes organic and inorganic chemicals, intermediates for food additives and pharmaceuticals, agricultural chemicals and feed additives. In the electronic components sector they manufacture electric machinery equipment and parts such as resistors and resistor boxes. They also produce high voltage measuring devices such as digital meters, probes and dividers. These products are mainly used in industrial equipments, chemical measuring instruments, X-ray apparatuses and electron microscopes.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Alpha Chemika, founded in 1989 and based in Mumbai, India, is a manufacturer, supplier of laboratory reagents and fine chemicals. Their products are used in multiple industries, including pharmaceutical, chemical, biotechnology, and environmental. Their product portfolio ranges from chemicals such as Silver Nitrate, Perchloric Acid, and Lanthanum Acetate to laboratory tools and equipment such as Air Inlet Tubes, Air Inlet Tubes, and Optical Components. Alpha Chemika has been able to obtain ISO 9001:2000 certification.
Hefei TNJ Chemical Industry Co., Ltd, established in 2001, is headquartered in China. The company is a chemical manufacturer and supplier of chemicals to domestic Chinese and global consumers in four primary markets: chemicals, food, pharmaceuticals, and personal care. Chemicals include fine chemicals, agrochemicals, and other chemicals. Food includes agrochemicals, vitamins, amino acids, and food ingredients. Pharmaceuticals include specific chemicals such as Povidone iodine, Clotrimazole crystalline, and Lincomycin. The company also features a CAS databank for CAS-registered chemical compounds.
MODY CHEMI PHARMA LTD, founded in Mumbai, Maharashtra, in 1989 is a manufacturer of lithium and bromine compounds and catalysts. The company's product portfolio includes DMH, Hydantoin, Tertbutyl Ammonium Bromide, and Calcium Bromide. Their products are used in industries such as Food and Beverage, Pharmaceutical and Biotechnology, Chemical and Petrochemical, Environmental Testing and healthcare. The company exports its products to countries in Europe, the USA, China and UAE. The company has a global distribution network and an R&D center.
Allychem Co., Ltd., established in 2004 in Jinzhou New District, Dalian, China, is a manufacturer specializing in organoboronic acids and derivatives. The company's extensive product portfolio includes Potassium Trifluoroborate and Tetrafluoroborate Salts, Arylboronic Acids and Derivatives, Heterocyclic Boronic Acids and Derivatives, Alkylboronic Acids and Derivatives, as well as chiral compounds. These organic chemicals serve various purposes, such as the rectification method used to reduce the water content of industrial methanol to below 0.01%, scientific research involving aryl-containing fine chemicals like medicines and pesticides, and biological applications for transmembrane transport, bio marking, and protein labeling.
Loba Chemie Pvt. Ltd. is a Mumbai-based manufacturer and supplier of laboratory and fine chemicals, catering to industries such as pharmaceuticals, food, research, hospitals, and universities since its establishment in 1975. Their product range includes pH indicators, biological stains, HPLC solvents, high purity acids, and tetrazolium salts and derivatives. These products serve various applications like pH testing, cell and tissue staining, chemical separation, and pharmaceutical manufacturing. The company has several certifications, such as ISO/IEC 17025:2017 and ISO 9001:2015.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Ranking as of November 2024
Derivation MethodRank | Company | Click Share |
---|---|---|
1 | Paras Polymer & Chemicals |
17.1%
|
2 | Allychem Co., Ltd. |
14.6%
|
3 | Alpha Chemika |
12.2%
|
4 | Ester India |
9.8%
|
5 | MODY CHEMI PHARMA LTD |
9.8%
|
6 | Hefei TNJ Chemical Industry Co.,Ltd. |
9.8%
|
7 | KANTO CHEMICAL CO.,INC. |
7.3%
|
8 | LobaChemie Pct.Ltd. |
4.9%
|
9 | SimSon Pharma Limited |
4.9%
|
10 | SRL |
2.4%
|
Derivation Method
The ranking is calculated based on the click share within the azobisisobutyronitrile page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
Country | Number of Companies | Share (%) |
---|---|---|
India | 8 | 66.7% |
Japan | 2 | 16.7% |
China | 2 | 16.7% |