This section provides an overview for phenyl acetate as well as their applications and principles. Also, please take a look at the list of 6 phenyl acetate manufacturers and their company rankings. Here are the top-ranked phenyl acetate companies as of November, 2024: 1.Spectrum Chemical Mfg. Corp., 2.BERJÉ INC, 3.Central Drug House.
Table of Contents
Phenyl acetate is an organic compound, classified as one of the phenolic esters, having the structure of dehydration-condensation of acetic acid and phenol. Its molecular formula is C8H8O2, molecular weight is 136.15, density is approximately 1.08 g/ml, and the CAS number is 122-79-2.
Other names include phenol acetate and acetoxybenzene.
Phenyl acetate is a colorless liquid that exhibits a phenolic odor at room temperature and pressure. It is almost insoluble in water and soluble in organic solvents such as ethanol, chloroform, and ether. It is synthesized by the reaction of acetic anhydride or acetyl chloride with phenol. In this reaction, the nucleophilic nature of the oxygen atom of phenol is utilized. It is synthesized by reacting with acetic anhydride or acetyl chloride, which are susceptible to nucleophilic substitution reactions.
The boiling point of this substance is approximately 384.8 °F (196 °C), but its flash point is 201 °F (94 °C). At temperatures above 176 °F (80 °C), there is a risk of spontaneous ignition or explosion. Therefore, it should be handled in a closed system and ventilated thoroughly.
Since it is irritating to the skin and eyes, rubber gloves and protective eyewear should be worn when handling it.
Uses of phenyl acetate include use as a raw material for synthesizing various organic compounds, such as enzyme substrates and inhibitors. It is a relatively inexpensive reagent that is readily available. However, this substance is not often used on its own.
Phenyl acetate has a benzene ring structure with an ester group attached to it, allowing various modifications to be made to the benzene ring. Many of the transmitters in the human body have such a structure and are therefore used as raw materials for drugs that target these transmitters and receptors. Since this substance is a substrate for esterases, it is used as a raw material for esterase inhibitors.
Phenyl acetate also rearranges to 2- or 4-hydroxyphenyl methyl ketone in the presence of Lewis acids and is used as a raw material for the synthesis of various aromatic organic compounds, mainly as nitrophenyl phenyl derivatives. Since this substance is an ester, it is neither acidic nor basic, and there are no nucleophilic or electrophilic moieties, making it very easy to handle.
It should be noted that the structural formula of phenyl acetate is CH3-COO-Ph, which is a different substance from phenyl acetate (Ph-CH2-COOH). Phenyl acetate has a carboxyl group and exhibits completely different properties.
One substance with a very similar structure derived from phenyl acetate is phenyl mercury acetate. This substance is an organometallic compound with a mercury atom inserted between an oxygen atom and a carbon atom on the benzene ring.
Phenyl mercury acetate was registered as an agricultural chemical in 1948 as a special agent to kill rice blast fungus, but it expired in 1973. At the time, the toxicity of methylmercury, which caused Minamata disease, was a hot topic of public debate, and phenyl mercury acetate, an organic compound that also contains mercury, was no longer used due to social unrest over mercury compounds.
However, methyl mercury was not detected in phenyl mercury acetate, and no toxicity was noted. However, there have been cases of poisoning during experiments and cases of poisoning during pesticide spraying. It is now being substituted by other pesticides and is no longer used.
This compound can be synthesized by heat refluxing mercury(II) acetate with trifluorosilylbenzene in benzene or by reaction of diphenylmercury with acetic acid.
*Including some distributors, etc.
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Spectrum Chemical MFG Corp. was founded in 1971, is headquartered in New Brunswick, New Jersey, and has facilities in Gardena, California. Spectrum is a fine chemical manufacturing company with an emphasis on USP, NF, FCC, BP, EP, JP, and ACS grade products, and is ISO 9001:2015 certified. Spectrum primarily serves the analytical, biopharmaceutical, food & beverage, personal care, and pharmaceutical chemicals industries. Spectrum has 4 product segments which are chemicals, equipment, supplies, and safety.
Berjé Inc. was originally founded in 1949 and is headquartered in Carteret, New Jersey. The company is a national wholesaler of over 2000 essential oils and aromatic chemicals sourced from local farmers around the world. The company has two product categories: essential & fixed oils and aromatic chemicals. Essential & fixed oils include essential oils and fixed oils while aromatic chemicals include natural aromatics and all aromatic chemicals. The company lists chemicals by four application categories which are flavor ingredients, fragrance ingredients, functional ingredients, and fragrances.
Parchem was founded in 1999 and headquartered in Rochelle, New York. Parchem is a distributor of industrial chemicals. Parchem serves nutritional, personal care, pharmaceutical, and specialty chemical industries. Parchem offerings include coatings, adhesives, elastomers, industrial products, petrochemicals, oleochemicals, plastics, rubber, nutritional supplements, cosmetics, consumer products, catalysts, metallic salts, rare earths, flavors & fragrances, industrial & institutional, textiles, other food-related chemicals, dyes, finishes, chemicals for aerospace, oil gas drilling chemicals, electronics, and pharmaceuticals.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ranking as of November 2024
Derivation MethodRank | Company | Click Share |
---|---|---|
1 | Spectrum Chemical Mfg. Corp. |
22.7%
|
2 | BERJÉ INC |
18.2%
|
3 | Central Drug House |
18.2%
|
4 | Parchem |
18.2%
|
5 | Otto Chemie Pvt. Ltd |
18.2%
|
6 | KANTO CHEMICAL CO.,INC. |
4.5%
|
Derivation Method
The ranking is calculated based on the click share within the phenyl acetate page as of November 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
Country | Number of Companies | Share (%) |
---|---|---|
United States of America | 3 | 50.0% |
India | 2 | 33.3% |
Japan | 1 | 16.7% |