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This section provides an overview for methyl cation as well as their applications and principles. Also, please take a look at the list of 1 methyl cation manufacturers and their company rankings. Here are the top-ranked methyl cation companies as of December, 2024: 1.Biosynth.
Table of Contents
A methyl cation, represented as CH3+, is formed when a hydrogen atom is removed from a methyl group (CH4). This results in a positively charged ion.
It is a type of carbocation, categorized based on the number of alkyl substituents: primary with one substituent, secondary with two, and tertiary with three.
Methyl cations are highly unstable and rarely exist in solution, making them rare participants in standalone reactions.
However, other carbocations often act as reaction intermediates, especially in the following two reactions:
The SN1 reaction, or unimolecular nucleophilic substitution, involves the elimination of a leaving group (like a halogen) from a molecule, forming a carbocation intermediate. This intermediate is then attacked by a nucleophile, leading to product formation.
The rate-limiting step is the formation of the carbocation intermediate, favoring compounds that stabilize tertiary carbocations.
The E1 reaction, or unimolecular elimination, resembles the SN1 reaction in its preference for compounds that stabilize tertiary carbocations.
Unlike SN1, a nucleophile extracts a hydrogen atom adjacent to the carbocation, leading to the formation of a double bond and possibly various geometrical isomers. However, the most thermodynamically stable alkene is usually the predominant product.
Methyl cations are characterized by their high energy and extreme instability. This lack of stability is attributed to the absence of hyperconjugation—a stabilization mechanism involving electron delocalization between a p-orbital and adjacent C-H bonds.
In other carbocations, hyperconjugation lowers energy and increases stability. The presence of more hydrocarbon groups adjacent to the carbocation enhances this effect, making tertiary carbocations the most stable. In contrast, methyl cations, with no adjacent hydrocarbon groups, are highly unstable.
Although methyl cations are inherently unstable, they can be carcinogenic when formed as metabolites. Prominent examples include:
Cycasin
Cycasin, a glycoside primarily found in cycads, is a plant-derived carcinogen. When metabolized by intestinal bacteria's β-glycosidase, it produces methyl cations, along with formaldehyde and other compounds. These methyl cations can alkylate DNA, RNA, and proteins, potentially leading to cancer.
Dimethylnitrosamine
Dimethylnitrosamine is formed when dimethylamine (commonly found in fish) reacts with nitrous acid in the stomach. In the body, cytochrome P450 oxidizes it, producing methyl cations that can alkylate DNA, increasing cancer risk. Notably, in Norway, there have been instances of food poisoning linked to herring feed containing dimethylnitrosamine.
*Including some distributors, etc.
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Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Biosynth |
100.0%
|
Derivation Method
The ranking is calculated based on the click share within the methyl cation page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Switzerland
|
1 | 100.0% |
