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This section provides an overview for dimethyl malonate as well as their applications and principles. Also, please take a look at the list of 15 dimethyl malonate manufacturers and their company rankings.
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Dimethyl malonate, a colorless to pale yellow liquid, is known chemically as dimethyl propanedioate.
Noted for its unique aroma, dimethyl malonate is used both as a fragrance and a food additive. Additionally, it is a precursor for jasmonic acids like methyl dihydrojasmonate, extensively used in high-end fragrances.
Dimethyl malonate reacts with urea under acidic conditions to synthesize barbituric acid, a central component in various CNS depressant drugs, although barbituric acid itself lacks CNS depressant effects.
It plays a crucial role in the malonate ester synthesis method, enabling the creation of α-substituted acetate esters. This involves base-induced carbo anion formation at the α-position of dimethyl malonate, followed by a reaction with an alkyl halide.
In Knebenagel condensation, dimethyl malonate serves as a substrate for synthesizing alkenes by reacting with ketones or aldehydes, leading to a carbo-anion that attacks the carbonyl carbon, forming an alkene through dehydration condensation.
Additionally, it finds application in producing agricultural chemicals and pharmaceuticals.
With the formula C5H8O4 and a molecular weight of 132.11, dimethyl malonate (CAS number 108-59-8) is a liquid at room temperature, featuring a melting point of -62°C and a boiling point of 181°C. Its density is approximately 1.152-1.158 g/ml at 20°C.
It exhibits weak aromatic properties, solubility in alcohols and ethers, and limited water solubility. The compound's pKa is 13, indicating its mild acidic nature influenced by the presence of two ester groups.
Produced from dimethoxymethane and carbon monoxide, or via direct esterification of methanol with malonic acid under azeotropic conditions.
Handling Precautions
Avoid exposure to strong oxidizing agents, use protective gear, and operate in a well-ventilated area. Dimethyl malonate is flammable, with a flash point of 83°C, necessitating caution around heat sources to prevent toxic fume release.
Storage Recommendations
It should be stored in glass containers, in cool, well-ventilated areas away from direct sunlight and ignition sources, with the storage location securely locked.
*Including some distributors, etc.
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Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
FujiFilm Wako Pure Chemical Corporation, founded in 1922 and headquartered in Osaka, Japan, is a manufacturer of laboratory chemicals, specialty chemicals, and clinical diagnostic reagents. The company has three business domains, namely laboratory chemicals, specialty chemicals, and clinical diagnostic reagents, and some of its products include biochemistry reagents, blood transfusion test drugs, battery materials, polymer-related materials, and general reagents. The products are useful in various fields, including electronic, cosmetic, polymeric, pharmaceutical, and medical care. It acquired Sibayagi Co. Ltd. in 2015 and provides custom manufacturing to meet customer requirements.
Hangzhou Keying Chem Co., Ltd. (HKC) is a Chinese manufacturer of fine chemicals and polymers that was established in 2010. Based in Hangzhou, Zhejiang, the company offers various fine chemicals such as reagents and catalysts, as well as polymers, active pharmaceutical ingredients (APIs), and feed additives. It also produces specialty chemicals including pesticides and natural as well as synthetic dyes. HKC products are used by clients in the agricultural and industrial sectors, including Mitsubishi Chemical, Sanofi, and Dow AgroSciences.
Shandong Xinhua Pharma is a pharmaceutical manufacturer headquartered in Shandong, China. The company has been operating since its establishment in 2006. Specializing in pharmaceutical production, Shandong Xinhua Pharma offers a wide range of products including active pharmaceutical ingredients (APIs), intermediates, and finished dosage forms. These products cater to various therapeutic categories such as cardiovascular, anti-infective, and central nervous system treatments. The company delivers comprehensive services including regulatory support, quality assurance, and customized solutions to meet the unique needs of its clients.
Alpha Chemika, founded in 1989 and based in Mumbai, India, is a manufacturer, supplier of laboratory reagents and fine chemicals. Their products are used in multiple industries, including pharmaceutical, chemical, biotechnology, and environmental. Their product portfolio ranges from chemicals such as Silver Nitrate, Perchloric Acid, and Lanthanum Acetate to laboratory tools and equipment such as Air Inlet Tubes, Air Inlet Tubes, and Optical Components. Alpha Chemika has been able to obtain ISO 9001:2000 certification.
SimSon Pharma Limited, established in 2011 and headquartered in Mumbai, India, is a manufacturer and supplier of pharmaceutical reference materials. Their product range includes drug working standards, drug impurity standards, drug metabolites, and stable isotope labeled compounds. These provide a basis for comparison and validation, enabling pharmaceutical companies to produce safe and effective medications. The company's offerings serve specific purposes, such as calibrating analytical instruments and ensuring precise analytical results, identifying and quantifying impurities in drugs, understanding drug metabolism, and developing new drug therapies.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Nacalai Tesque Inc., founded in 1846 and headquartered in Kyoto, Japan, is a manufacturer of research chemicals, fine chemicals, diagnostics, and the related instruments. Some of its products include cytokines, nucleic acid electrophoresis, cell dissociation reagents, and sialic acid-related products, and it also offers custom and bulk service for bulk reagents and cell culture media. The company has more than 50 domestic distributors and several worldwide, including Asia, the Middle East, Oceania, Europe, and Africa. It is ISO 9001 and ISO 9002 certified, while the Kyoto South brand and Tesque factory are ISO 14001 certified.
Starsky international holdings Co., Ltd., established in 1984 and headquartered in Shanghai, China, is a manufacturer of organic and inorganic chemicals. The company provides APIs, organic and inorganic chemicals, food additives, fragrances and catalysts with customized service based on customers’ demands. It has two production facilities and complies with quality standards including ISO 9001 and 14001, GMP and Kosher. With independent export rights, the company exports its products to over 100 countries including USA, England, France, Germany and Thailand.
Jigs Chemical was established in 1998 and is based in India with global offices in the USA, UK, Canada, and Australia. Jigs Chemical is a manufacturer, distributor, and marketing & sales provider for organizations in India, specializing in chemicals and active pharmaceutical ingredients for pharmaceutical, agriculture, ceramics, metal treatment, and other industries. Jigs Chemical helps facilitate international customers to obtain chemicals from India, providing import and export assistance. Jigs Chemical’s product catalog includes over 40000 active pharmaceutical ingredients, commonly called APIs, their respective intermediates, and other chemicals.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
Founded in 1981, Central Drug House Ltd. serves the scientific community via manufacturing and marketing a library of over 9,000 products to laboratory fine chemicals and dehydrated culture media with emphasis on purity and service. Examples are acids & bases, adsorbents, disinfectants, indicator papers, oils, and solvents. CDH provides bio chemicals, research chemicals, laboratory reagents, various solvents, stains & indicators, and dehydrated culture media. CDH is ISO 9001 certified and CDHs’ products are in compliance with specifications of IP, BP, USP, and EP standards.
National Analytical Corporation (NAC) is located in Mumbai, India. NAC was founded in 2009 as a distributor of laboratory grade chemicals used in numerous industries. NAC’s chemical offerings include biochemical & reagents such s Prunetin and 1,2-dipalmitoly-rac-glycerol, analytical grade chemicals such as chicoric acid and Vitamin E solutions, laboratory chemicals such as formic acid and nitric acid, gas chromatography chemicals such as Aalborg mass flowmeter battery kits and DEX 225, reference standard chemicals such as Palladium in HNO3, oral solid dosage forms, such as cellulosic and protect film coating systems, parenteral dosage forms, beverage & nutrition, and coating chemicals.
Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
Japan
|
5 | 41.7% |
|
India
|
5 | 41.7% |
|
China
|
2 | 16.7% |
