7 Fosfomycin Manufacturers in 2024
This section provides an overview for fosfomycin as well as their applications and principles. Also, please take a look at the list of 7 fosfomycin manufacturers and their company rankings. Here are the top-ranked fosfomycin companies as of April, 2024: 1.Blink Health Administration LLC, 2.GoldBio, 3.LGC Standards.
Table of Contents
What Is Fosfomycin?
Fosfomycin, an antibacterial drug produced by actinomycetes of the genus Streptomyces and synthesized from phosphoenolpyruvate, stands out as the only one in its class without a common strain among antibacterials. It comes in both drinkable and injectable forms, with a chemical formula of C3H5CaO4P・H2O for the drinkable version and a similar composition for the injectable form, differing by the presence of calcium (Ca) in the former and sodium (Na) in the latter. Marketed under the trade name "fosmisin," it is effective against a wide range of Gram-positive and Gram-negative bacteria.
Uses of Fosfomycin
Fosfomycin's broad spectrum of activity makes it a versatile option, particularly as a second-line treatment against multidrug-resistant bacteria. Its effectiveness varies between oral and injectable forms, targeting bacteria such as Staphylococcus spp., Escherichia coli, Serratia spp., Proteus spp., Morganella morganii, Providencia rettigeli, and Pseudomonas aeruginosa, with the oral form also acting against dysentery bacilli, Salmonella, and Campylobacter spp. It is indicated for pyelonephritis and cystitis among other infections, with the oral form being metabolized through the gastrointestinal tract for intestinal infections, and the injectable form used for sepsis and infections of the lungs and uterus.
Properties of Fosfomycin
1. Mechanism of Action
Fosfomycin inhibits the initial stage of cell wall synthesis, a unique mechanism of action compared to beta-lactam antibiotics, which also target cell wall synthesis but at different stages.
2. Drug Resistance
Though reports of resistance to fosfomycin are less common than with other antibiotics, mutations can confer resistance, notably diminishing its efficacy against strains of Pseudomonas aeruginosa and Escherichia coli.
3. Pharmacokinetics
After administration, fosfomycin is distributed and excreted unchanged in urine. Impaired renal function may hinder its elimination, necessitating dosage adjustments based on the severity of renal impairment.
Characteristics of Fosfomycin
Notably effective under anaerobic conditions, fosfomycin's oral form is particularly suited for treating intestinal infections, contrasting with aminoglycosides, which are less effective in the absence of oxygen.
Other Information About Fosfomycin
1. Contraindications and Prudent Dosage
While no specific contraindications exist for the oral form, the injectable form should not be used by those with a known hypersensitivity to fosfomycin. Special care is required for patients with a familial history of allergic reactions or hepatic impairment due to the risk of adverse reactions, including increased hepatic enzymes.
2. Points of Caution
Both formulations necessitate caution in patients with renal impairment, particularly the elderly. The injectable form, due to its sodium content, also requires careful consideration in patients with conditions that demand sodium intake restrictions.
3. Adverse Effects
Adverse effects, including severe colitis, pancytopenia, agranulocytosis, thrombocytopenia, and convulsions, have been reported for both forms of fosfomycin, though the exact frequency of these events is unknown.
List of 7 Fosfomycin Manufacturers
*Including some distributors, etc.
Sort by Features
- Default
- Company Size: largest first
- Year Founded: oldest first
- Year Founded: earliest first
Sort by Area
- United States of America
- Philippines
- United Kingdom
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GoldBio
Fosfomycin Sodium
Distributor Overview
GoldBio, founded in the United States in 1986, is a supplier of quality lab products for research and molecular biology. The company offers a range of lab consumables, including pipettes, tubes, plates, and more, to support precise and efficient molecular biology research and a wide array of reagents and kits for applications in genomics, proteomics, cell biology, and other critical areas of study. Its products are used for clinical diagnostics to ensure accurate and reliable test results for healthcare providers.
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Blink Health Administration LLC
Monurol (Generic)
Distributor Overview
Blink Health Administration LLC, founded in 2014 and based in New York, USA, is a web-based platform supplier for users to find prescription medications online. Its service offerings include access to affordable prescription drugs, local pharmacy pickup, home delivery, online provider visits with licensed medical professionals, and a price match guarantee on generic medications. Its services empower individuals to access essential prescription medicines at economical prices, simplifying the process of obtaining needed healthcare treatments.
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LGC Standards
Fosfomycin calcium CRS
Manufacturer Overview
LGC Standards Ltd., established in 1842, is a global British manufacturer and supplier of reference standards, headquartered in Teddington, Middlesex, with offices in 20 countries worldwide. As a subsidiary of LGC Group, the United Kingdom’s National Measurement Institute, LGC Standards also serves as the Government Chemist, providing expert opinions based on independent chemical and bioanalytical measurements. Under the business unit LGC Industrial, the company offers industrial measurement tools. Additionally, their subsidiaries, including Toronto Research Chemicals Inc (TRC) of Canada, LGC Mikromol™, and Dr. Ehrenstorfer™ of Germany, develop research tools, standards for pharmaceutical quality control, and reference materials for food and environmental analysis.
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MilliporeSigma
Fosfomycin Trometamol
Manufacturer Overview
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
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Universal Drugstore
Monurol
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GoodRx, Inc.
Phosphomycin
Distributor Overview
GoodRx, founded in 2011, and headquartered in Santa Monica, California, is a service supplier that offers a comprehensive suite of healthcare-related services. Its primary service involves comparing prescription drug prices at a vast network of over 75,000 pharmacies throughout the United States, assisting users in finding the most cost-effective options for its medications. The company also provides free drug coupons, which can significantly reduce the out-of-pocket expenses for prescription medications. It operates a telemedicine platform that facilitates online consultations with healthcare professionals, allowing users to receive medical advice and, in some cases, obtain prescriptions for specific medications.
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Fosfomycin Manufacturer Ranking
*Including some distributors, etc.Ranking as of April 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Blink Health Administration LLC |
23.1%
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| 2 | GoldBio |
23.1%
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| 3 | LGC Standards |
15.4%
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| 4 | MilliporeSigma |
15.4%
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| 5 | Universal Drugstore |
7.7%
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| 6 | The Cathay Drug Company, Inc. |
7.7%
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| 7 | GoodRx, Inc. |
7.7%
|
Derivation Method
The ranking is calculated based on the click share within the fosfomycin page as of April 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
- The Cathay Drug Company, Inc.: 1952 (72 years ago)
Company with a History
- The Cathay Drug Company, Inc.: 1952 (72 years ago)
Fosfomycin Manufacturers in United States
*Including some distributors, etc.
Global Distribution of Fosfomycin Manufacturers by Country
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
United States of America
|
2 | 50.0% |
United Kingdom
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1 | 25.0% |
Philippines
|
1 | 25.0% |
