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This section provides an overview for foscarnet as well as their applications and principles. Also, please take a look at the list of 8 foscarnet manufacturers and their company rankings. Here are the top-ranked foscarnet companies as of December, 2024: 1.Biosynth, 2.America's Pharmacy, 3.MilliporeSigma.
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Foscarnet, also known as phosphonomethanoic acid, is an antiviral compound with the formula CH3O5P. Its structure integrates formic acid with phosphoric acid, leading to its unique antiviral properties. Marketed primarily as Foscarnet sodium hydrate, it's recognized under CAS numbers 4428-95-9 for the sodium salt and 34156-56-4 for the sodium hydrate.
Foscarnet sodium hydrate is employed as an antiviral chemotherapeutic agent, particularly effective against cytomegalovirus (CMV) infections and human herpesvirus 6 encephalitis. It's vital for treating CMV retinitis in AIDS patients, CMV infections in stem cell transplant recipients, and encephalitis post-transplantation. Marketed as Foscavir by Clinigen Corporation, it's not recommended for congenital or neonatal CMV infections or as a preventive measure.
Typically isolated as Foscarnet sodium hydrate, it appears as a white crystalline powder, with a molecular weight of 300.04 and formula CNa3O5P - 6H2O. Its solubility is limited to water, showing minimal solubility in ethanol and almost none in diethyl ether.
Foscarnet is available both as a pharmaceutical product for medical use and as a reagent for research. The drug version is provided in 250 mL vials for intravenous infusion at 24 mg/mL, while research-grade foscarnet is sold in various quantities from 25 mg to 100 g.
Foscarnet acts by mimicking pyrophosphoric acid, selectively inhibiting viral DNA polymerase without affecting human DNA synthase. This mechanism blocks the replication of CMV and human herpesvirus 6.
Prescribed under strict medical supervision, Foscarnet requires monitoring for potential decreases in serum calcium, magnesium, and potassium levels. Precautions include monitoring for hypersensitivity reactions, ensuring genital tract hygiene to prevent irritation and ulceration, and conducting thorough medical interviews to anticipate severe adverse reactions.
*Including some distributors, etc.
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MedChemExpress (MCE), is headquartered in Monmouth Junction, New Jersey, and is a supplier of research chemicals and biochemicals for laboratory and scientific use. The company’s product range includes biochemical assay reagents, isotope-labeled compounds, inhibitory antibodies, recombinant proteins, and fluorescent dyes. These products are used in various biopharmaceutical research and development fields, including areas such as infection, cardiovascular diseases, neurodegenerative diseases, diabetes, and autoimmune diseases. The company is ISO 19001 certified and provides testing services within the ISO 17025 framework, offering bulk and custom product services and support for metrological traceability.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
LKT Laboratories, Inc., established in 1989 and based in St. Paul, Minnesota, is a biochemical supplier and manfuacturer primarily specializing on the synthesis, purification, and isolation of small molecules for research applications. Offering various products like protein kinase inhibitors, ion channel modulators, and activators, these substances are utilized for its biological activities, especially in cancer and neuroscience research. It serves the global research community by supplying the highest purity products for use in cell culture models, animal studies, or as reference materials or analytical standards.
Henry Schein Inc., established in 1932 and headquartered in Melville, New York, U.S., is a global distributor of healthcare products and related services. The company offers medical, dental, and veterinary supplies as well as equipment and technology solutions. Its products are utilized by healthcare professionals and organizations for patient care and practice management. The company operates in compliance with ISO 9001 and ISO 14001 guidelines, adhering to quality assurance and environmental management standards.
Blink Health Administration LLC, founded in 2014 and based in New York, USA, is a web-based platform supplier for users to find prescription medications online. Its service offerings include access to affordable prescription drugs, local pharmacy pickup, home delivery, online provider visits with licensed medical professionals, and a price match guarantee on generic medications. Its services empower individuals to access essential prescription medicines at economical prices, simplifying the process of obtaining needed healthcare treatments.
Biosynth is a Swiss manufacturer of life science reagents established in 1966 and headquartered in Staad. The company sources and manufactures biochemical products such as carbohydrates, nucleosides, and enzyme substrates, as well as various peptides and biologics. They also operate as a contract manufacturer offering custom synthesis and manufacturing services for their clients in the pharmaceutical, diagnostic, food, and agrochemical sectors. Biosynth has regional sales offices and specialized facilities in Europe and North America, including in the Netherlands, United Kingdom, and United States.
Millipore Sigma, formerly known as Sigma-Aldrich, was created in 175 through the merger of Sigma Chemical Company and Aldrich Chemical company and today is a subsidiary of Merck. Millipore Sigma is a life science and biotechnology company serving the industry with several products and services. Some of their product categories include peptide synthesis materials, biochemicals, building blocks, catalysts, chemical biology, chemical synthesis, flavors & fragrances, formulation, lab chemicals, lab safety, APIs, and stable isotopes. Services include characterization, contract manufacturing, custom products, software, support, testing, and mRNA development & manufacturing.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | Biosynth |
71.4%
|
| 2 | America's Pharmacy |
14.3%
|
| 3 | MilliporeSigma |
14.3%
|
Derivation Method
The ranking is calculated based on the click share within the foscarnet page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
6 | 85.7% |
|
Switzerland
|
1 | 14.3% |
