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This section provides an overview for phenylboronic acid as well as their applications and principles. Also, please take a look at the list of 15 phenylboronic acid manufacturers and their company rankings. Here are the top-ranked phenylboronic acid companies as of December, 2024: 1.SRL, 2.Combi-Blocks Inc., 3.Merck.
Table of Contents
Phenylboronic acid is an organoboron compound.
It has the molecular formula C6H7BO2 and consists of a boron atom bonded to two hydroxy groups and one phenyl group. The phenyl group (C6H5-) is sometimes abbreviated to Ph and written as PhB(OH)2. It is also known as phenylboric acid and benzeneboric acid, and its CAS number is 98-80-6.
It has a molecular weight of 121.93, a melting point of 216°C, and is a white or yellow, odorless crystal or powder at room temperature. It is characterized by its solubility in polar organic solvents. On the other hand, it is virtually insoluble in non-polar solvents such as hexane and carbon tetrachloride. Phenylboronic Acid is a weak Lewis acid with an acid dissociation constant pKa of 8.83.
Phenylboronic acid is used in various organic syntheses, taking advantage of its properties and reactivity as a weak Lewis acid. Examples of typical reactions include the Suzuki-Miyaura coupling reaction for the synthesis of biaryl compounds and palladium-catalyzed direct arylation.
Other compounds are used for their reactivity to make sensors and receptors for hydrocarbons and N-type polymers for all-polymer solar cells. Medical applications include antibiotics, enzyme inhibitors, and neutron capture therapy.
In biochemistry and chemical biology, the substance can also be used in biological reactions such as membrane permeation transport, bio-conjugation reactions, and protein labeling.
The boron atoms of phenylboronic acid have empty p orbitals due to sp2 hybridization, and the molecular structure is a planar molecule with C2v molecular symmetry. This planar molecule is hydrogen bonded in bimolecular units with a slight bend across the C-B bond, and the angles formed by the planes of the two PhB (OH) bimolecules are 6.6° and 21.4°, respectively.
These dimeric units form hydrogen bonds with each other to form a rectangular molecular crystal system.
Phenylboronic acid is sold primarily as a reagent for research and development. The types of volumes include 1 g, 10 g, 25 g, 50 g, 100 g, and 500 g. It is a reagent product that can be stored at room temperature.
Phenylboronic acid anhydride may be included as an impurity.
There are many methods for synthesizing phenylboronic acid. The following is a list of some of the most representative ones.
Phenylboronic acid is dehydrated to form the trimeric anhydride, boroxyn. This dehydration reaction proceeds thermally, and in some cases, a drying agent is added.
The compound is also useful as a reactant in cross-coupling reactions. A typical example is the Suzuki-Miyaura coupling, in which aryl halides react with phenylboronic acid in the presence of a palladium catalyst and base to produce biaryls.
α-Amino acids can be synthesized without the use of a catalyst by reacting α-keto acids, amines, and phenylboronic acid. There are also reports of Heck's reactions using phenylboronic acid and alkenes or alkynes.
*Including some distributors, etc.
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AK Scientific, Inc. (AKS) is an American advanced intermediates and fine chemicals manufacturer that was established in Union City, California in 1997. The company’s product lineup includes chemical biocides, bioactives, inhibitors, and reagents. It also offers a range of products for use in life science applications, such as screening compounds, organoborons, and molecular fluorophores. These are extensively used in agrochemicals, biotech, pharmaceuticals, and nanotechnology. Aside from its products, AKS also offers international procurement and sourcing services to its clients, which include AstraZeneca, Sanofi-Aventis, and Bristol-Myers Squibb.
Oakwood Chemical is based in Estill, South Carolina. The company is a producer of a wide range of organics with particular emphasis on fluorine and sulfur compounds. The company also offers custom synthesis services and bulk quantities upon request. The company has independent operations and operations in collaboration with the University of South Carolina. The company’s suppliers include ChemCollect, Chess, KISHIDA CHEMICAL Co., Ltd., and Tetramer. The company’s featured products include boronic acids and esters, peptide coupling, fluorinated amines, and reagents for synthesis.
Santa Cruz Biotechnology, Inc., established in 1991 and headquartered in Dallas, Texas, is an American manufacturer and supplier specializing in biological products for medical research. Initially providing antibodies to the research community, they expanded their offerings to include gene silencers like siRNA and shRNA (plasmid and lentiviral), targeting all known mouse and human genes. Over time, Santa Cruz Biotechnology provides over 175,000 research biochemicals under the brand ChemCruz, including protein-interacting inhibitors, substrates, and activators, tailored for studying protein functions. The company offers monoclonal primary antibodies, designed for various mammalian and non-mammalian protein targets, along with corresponding binding secondary antibodies.
Kanto Chemical Co. Inc., founded in 1944 and headquartered in Tokyo, Japan, is a reagent manufacturer with overseas affiliates in other countries, including China, France, USA, Taiwan, and Malaysia. Its product portfolio includes analytical reagents, ionic liquids, Iodine compounds, ultra-pure chemicals, and water analysis kits. The company is also developing regenerative medicine and genetics reagents and has over 50,000 products. It has several certifications, including ISO 9001, acquired in 1994, making it the first Japanese company in the reagent industry. Other certifications are ISO 14001, ISO 13485, and ISO/IEC 17025.
Junsei Chemical Co. Ltd., established in 1948 and headquartered in Tokyo, Japan, is a manufacturer of chemical reagents and chemical products, including commissioned synthesis of chemical products. Some of the products it makes include Sodium chloride solution, concentrated glycerin, calcium chloride, ascorbic acid, and nitric acid. The chemical products have a wide range of applications and can be used in pathological examination, as food additives, for analysis, and in the pharmaceutical industry. All its plants, including its research institute, are ISO4001 and ISO9001 certified, while its Saitama and Ibaraki plants are equipped with buildings that comply with GMP.
Kishida Chemical Co. Ltd., established in 1924 and headquartered in Osaka, Japan, is a manufacturer of reagents and high-purity chemicals and also does drug discovery support activities. Its product portfolio includes fine chemicals, research chemicals, ionic liquid, organic micro-analytical reagents, and chemical reagents for analysis. The products support several industries, including reagent business, battery material, drug discovery, and life science. The company is ISO 14001 certified and supplies several companies worldwide, including Meterion Advanced Chemicals Inc., Acros Organics, ChemBridge Corporation, Decon Laboratories, and InerBioScreen Ltd.
LGC Standards Ltd., established in 1842, is a global British manufacturer and supplier of reference standards, headquartered in Teddington, Middlesex, with offices in 20 countries worldwide. As a subsidiary of LGC Group, the United Kingdom’s National Measurement Institute, LGC Standards also serves as the Government Chemist, providing expert opinions based on independent chemical and bioanalytical measurements. Under the business unit LGC Industrial, the company offers industrial measurement tools. Additionally, their subsidiaries, including Toronto Research Chemicals Inc (TRC) of Canada, LGC Mikromol™, and Dr. Ehrenstorfer™ of Germany, develop research tools, standards for pharmaceutical quality control, and reference materials for food and environmental analysis.
Hefei Home Sunshine Pharmaceutical Technology Co., Ltd. (HHSPT) is a Chinese ISO 9001 certified manufacturer of intermediates, active pharmaceutical ingredients (APIs), and fine chemicals founded in 2013 and based in Hefei City. The company offers over 5,000 different products including coenzyme and nucleotide series chemicals, as well as APIs for the treatment of conditions such as diabetes and chronic liver disease. It also provides reagents and chemicals used for research and analysis applications. HHSPT products are primarily used by drug manufacturers, as well as by clients in laboratory R&D and the biotechnology industry.
Pharmaffiliates, established in 2001 and located in Gurgaon, India, is a manufacturer of pharmaceutical standards and services. The company provides Certified Reference Standards (CRS) used in analytical methods, as well as drug delivery systems like tablets, capsules, injectables, and deuterated compounds that aid in research and development, studying drug metabolism and pharmacokinetics. Pharmaffiliates also offers various services to the pharmaceutical industry, including custom synthesis, analytical research, stability studies, and formulation development.
Merck, started in 1668 and based in Darmstadt, Germany, is a supplier of solutions and services for research, development, and manufacture of pharmaceutical and biotechnological drug therapies. The company serves the life science industry and has a broad portfolio of 300,000 products, including biopharmaceutical manufacturing, industrial microbiology, reagent, life science research, and water purification products. It is available in 66 countries, brings together six brands, and has several ISO certifications, including ISO 13485, ISO 14001, ISO 13485, and ISO 50001.
Boron Molecular is a manufacturer and supplier of specialty chemicals such as agents, energy storage compounds, monomers and polymers. It was established in 2001 and is headquartered in Noble Park, Victoria, Australia. The company produces a wide range of specialty chemicals, including boron compounds, boronic acids, and organic building blocks. Its products, such as B2O3, H3BO3, tetrakis(hydroxymethyl) borate, 1,2-dihydroxy borate, and Yb3+-doped YAG laser crystal, are used by a number of industries, as diverse as pharmaceutical, chemical, and materials industries. Boron Molecular also provides a range of services, including custom synthesis, formulation, packaging, and logistics.
Combi-Blocks Inc., established in 1997 and headquartered in San Diego, California, USA, is a research-driven manufacturer and global supplier of laboratory reagents. The company specializes in the research, development, and distribution of combinatorial building blocks, organic compounds, and fine chemicals, making them a pivotal player in providing essential materials for scientific research and chemical synthesis worldwide. Its diverse product range encompasses boronic acids, imidazoles, indoles, oxindoles, and nitrobenzenes. These offerings find applications across pharmaceuticals, biotechnology, and various chemical industries.
Sisco Research Laboratories Pvt. Ltd. was established in 1975 and is headquartered in Mumbai, Maharashtra, India. The company manufactures highly complex reagents and biochemicals for public and private customers across industries with over 5000 products in different grades and packing sizes across product segments. The company’s 6 product categories are General Laboratory Chemicals & Solvents, Biochemicals & Specialty Fine Chemicals, Animal Cell Culture, Nanotechnology Products, Dehydrated Culture Media & Media Kits, and Biolit™ range of DNA and Protein tools.
SLS Scientific Laboratory Supplies Limited, founded in 1991 and headquartered in Dublin, Ireland, operates as a distributor of laboratory products and services. Its extensive product range includes chemicals for experiments, consumables like pipettes and gloves, diverse laboratory equipment for tasks such as measuring and mixing, as well as essential furniture pieces like cabinets and benches. Furthermore, the company provides supplementary services, including calibration, repair, maintenance, and training, to facilitate laboratory operations. The company also holds several certifications, such as ISO 9001 / ISO 14001 and REGO certification.
Founded in Mumbai, India in 2006, Otto Chemie Pvt. Ltd. is an ISO 9001:2015 & GMP certified chemical manufacturing company and distributor. Otto Chemie serves customers in many industries including agriculture and food processing, pharmaceuticals, oil & gas, cement, as well as educational and R&D industries. Product offerings include antibiotics, amino acids, vitamins, detergents, ionic liquids, materials science compounds, labware, oil, metal & ceramic science compounds and tools, oils, reagents, solvents.
Ranking as of December 2024
Derivation Method| Rank | Company | Click Share |
|---|---|---|
| 1 | SRL |
27.3%
|
| 2 | Combi-Blocks Inc. |
18.2%
|
| 3 | Merck |
18.2%
|
| 4 | Boron Molecular |
9.1%
|
| 5 | SLS Scientific Laboratory Supplies Limited |
9.1%
|
| 6 | Otto Chemie Pvt. Ltd |
9.1%
|
| 7 | KANTO CHEMICAL CO.,INC. |
9.1%
|
Derivation Method
The ranking is calculated based on the click share within the phenylboronic acid page as of December 2024. Click share is defined as the total number of clicks for all companies during the period divided by the number of clicks for each company.Number of Employees
Newly Established Company
Company with a History
*Including some distributors, etc.
*Including some distributors, etc.
| Country | Number of Companies | Share (%) |
|---|---|---|
|
United States of America
|
3 | 25.0% |
|
Japan
|
3 | 25.0% |
|
India
|
3 | 25.0% |
|
United Kingdom
|
2 | 16.7% |
|
China
|
1 | 8.3% |
